Results 81 to 90 of about 22,667 (274)

Structure and Dynamics of Erupting Solar Prominences Using the Rolling Hough Transform: Toward a Feature-oriented Classification

The Astrophysical Journal
The classification of solar prominences has proven to be challenging, due to their diverse morphologies and dynamical behavior. Complexity is heightened when considering eruptive prominences, where the dynamics demand methods capable of capturing ...
Harry Birch, Stéphane Régnier
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

High-resolution Observation of Solar Prominence Plumes Induced by Enhanced Spicular Activity

The Astrophysical Journal Letters
Solar prominences are the most prominent large-scale structures observed above the solar limb in emission in chromospheric lines but in absorption in coronal lines. At the bottom of prominences often appears a bubble, with plumes occasionally rising from
Wensi Wang, Rui Liu, Runbin Luo, Xiaoli Yan   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

An approach to psoriasis in general practice

South African Family Practice, 2012
Psoriasis is a genetically determined inflammatory and proliferative disease of the skin, presenting with sharply demarcated scaly plaques, especially on the extensor prominences and the scalp.
M.H. Motswaledi, L. Nkosi
doaj   +1 more source

Determination of Prominence Plasma Beta from the Dynamics of Rising Plumes

, 2012
The launch of Hinode satellite led to the discovery of rising plumes, dark in chromospheric lines, in quiescent prominences that propagate from large (~10 Mm) bubbles that form at the base of the prominences.
Hillier, Andrew, Hillier, Richard, Tripathi, Durgesh   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Near-Limb Zeeman and Hanle Diagnostics

, 2013
"Weak" magnetic-field diagnostics in faint objects near the bright solar disk are discussed in terms of the level of non-object signatures, in particular, of the stray light in telescopes.
A.D. Romanov, B. Lyot, B.A. Ioshpa, D. Socker, E. Tandberg-Hanssen, E. Tandberg-Hanssen, G. Newkirk Jr., G.M. Nikolskii, G.M. Nikolskij, G.Y. Smol’kov, H. Lin, H. Nagaoka, H. Peter, H. Zirin, I. Kim, I.S. Kim, I.S. Kim, I.S. Kim, J. Chae, J. Wagner, J.M. Malville, J.W. Harvey, O. En den, R.G. Athay, R.H. Lee, R.H. Lee, R.J. Terrile, S. Keil, S. Tomczyk, T.R. Rimmele, V.S. Bashkirtsev   +30 more
core   +1 more source