Results 61 to 70 of about 1,389,605 (343)
Linked Heritage: achievements and next steps
Archeomatica, 2013 Linked Heritage: achievements and next steps Linked Heritage is a Best Practice Network which includes ministries, responsible government agencies, content providers and aggregators, leading research centres, publishers and SMEs from 20 EU countries ...
Antonella Fresa
doaj
Chromatin accessibility dynamics across C. elegans development and ageing
eLife, 2018 An essential step for understanding the transcriptional circuits that control development and physiology is the global identification and characterization of regulatory elements.
Jürgen Jänes +15 more
doaj +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
TERT Promoter Mutations in Thyroid Cancer
Hormones & cancer, 2016 The 2013 discovery of Telomerase reverse transcriptase (TERT) promoter mutations chr5, 1,295,228 C>T (C228T) and 1,295,250 C>T (C250T) in thyroid cancer represents an important event in the thyroid cancer field and much progress has occurred since then ...
A. Alzahrani +3 more
semanticscholar +2 more sources
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Studia Universitatis Babeş-Bolyai. Musica, 2013 Although identifying and defining texture as a specific sound organization in sound mass compositions comes about frequently in contemporary musicology, only a handful of researchers regard this as a tendency of what turns out to be a large number of ...
Andrei C. COZMA
doaj
Frontiers in Genetics, 2020 The CD69 gene encodes a C-type lectin glycoprotein with immune regulatory properties which is expressed on the cell surfaces of all activated hematopoietic cells.
Jennifer Redondo-Antón +6 more
doaj +1 more source
TERT Promoter Mutations and Risk of Recurrence in Meningioma.
Journal of the National Cancer Institute, 2016 The World Health Organization (WHO) classification and grading system attempts to predict the clinical course of meningiomas based on morphological parameters.
F. Sahm +32 more
semanticscholar +1 more source