Results 1 to 10 of about 593,633 (298)
Genetic recombination is targeted towards gene promoter regions in dogs. [PDF]
PLoS Genetics, 2013 The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals.
Adam Auton +12 more
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Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes [PDF]
Nature CommunicationsCis-regulatory elements (CREs) are noncoding DNA regions regulating cell-type-specific gene expression programs by interacting with distal gene promoters.
S. Haydar +15 more
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Growth hormone deficiency in three siblings homozygous for a rare GH1 haplotype [PDF]
Frontiers in EndocrinologyIntroductionGrowth Hormone (GH), secreted by the anterior pituitary gland, is a key regulator of postnatal growth. Mutations in the GH1 gene can lead to isolated GH deficiency (IGHD), a rare disorder characterized by growth failure and severe short ...
Ana Cláudia Ribeiro +3 more
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Building the Frequency Profile of the Core Promoter Element Patterns in the Three ChromHMM Promoter States at 200bp Intervals: A Statistical Perspective [PDF]
Genomics & Informatics, 2015 Recently, the Encyclopedia of DNA Elements (ENCODE) Analysis Working Group converted data from ChIP-seq analyses from the Broad Histone track into 15 corresponding chromatic maps that label sequences with different kinds of histone modifications in ...
Heather Lent +2 more
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Journal of Genetic Engineering and Biotechnology, 2021 Background Potato (Solanum tuberosum L.) is one of the most important food crops in the world. Pathogens remain as one of the major constraints limiting potato productivity.
Atnafu Kebede, Mulugeta Kebede
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SN Applied Sciences, 2021 The gene transcription of bacteria starts with a promoter sequence being recognized by a transcription factor found in the RNAP enzyme, this process is assisted through the conservation of nucleotides as well as other factors governing these intergenic ...
Gustavo Sganzerla Martinez +3 more
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Insights into alpha-hemolysin (Hla) evolution and expression among Staphylococcus aureus clones with hospital and community origin. [PDF]
PLoS ONE, 2014 Alpha-hemolysin (Hla) is a major virulence factor in the pathogenesis of Staphylococcus aureus infection, being active against a wide range of host cells. Although hla is ubiquitous in S.
Ana Tavares +8 more
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Scientific Reports, 2021 We investigated the association between genetic variants in the histone modification regions and the prognosis of lung adenocarcinoma after curative surgery. Potentially functional SNPs were selected using integrated analysis of ChIP-seq and RNA-seq. The
Hyo-Gyoung Kang +20 more
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Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation
Frontiers in Genome Editing, 2023 DNA regulatory elements intricately control when, where, and how genes are activated. Therefore, understanding the function of these elements could unveil the complexity of the genetic regulation network.
Jeong Hoon Han +3 more
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BMC Biotechnology, 2020 Background Promoters that confer expression in fruit tissues are important tools for genetic engineering of fruit quality traits, yet few fruit-specific promoters have been identified, particularly for citrus fruit development.
Kasturi Dasgupta +6 more
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