Results 1 to 10 of about 580,872 (201)

Genetic recombination is targeted towards gene promoter regions in dogs. [PDF]

PLoS Genetics, 2013
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals.
Adam Auton, Ying Rui Li, Jeffrey Kidd, Kyle Oliveira, Julie Nadel, J Kim Holloway, Jessica J Hayward, Paula E Cohen, John M Greally, Jun Wang, Jun Wang, Carlos D Bustamante, Adam R Boyko   +12 more
doaj   +18 more sources

A case of Dravet syndrome with a novel SCN1A gross deletion involving the promoter region [PDF]

Human Genome Variation
Here we present a case of Dravet syndrome in which a novel heterozygous deletion involving the promoter region of the SCN1A gene was identified using next-generation sequencing and multiple ligation-dependent probe amplification.
Eri Nakahara Sakamoto, Shino Shimada, Tokito Yamaguchi, Tomoya Ishida, Katsumi Imai, Hidetaka Eguchi, Yasushi Okazaki, Masami Arai   +7 more
doaj   +2 more sources

Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi [PDF]

BMC Gastroenterology, 2006
Background Hepatitis B virus (HBV) genotypes have distinct geographic distribution. Moreover, much genetic variability has been described in the precore (PC) and basal core promoter (BCP) regions of the HBV genome.
Naqvi Syed, Siddiqui Arif, Muzaffar Rana, Abbas Zaigham, Rizvi Syed   +4 more
doaj   +4 more sources

Building the Frequency Profile of the Core Promoter Element Patterns in the Three ChromHMM Promoter States at 200bp Intervals: A Statistical Perspective [PDF]

Genomics & Informatics, 2015
Recently, the Encyclopedia of DNA Elements (ENCODE) Analysis Working Group converted data from ChIP-seq analyses from the Broad Histone track into 15 corresponding chromatic maps that label sequences with different kinds of histone modifications in ...
Heather Lent, Kyung-Eun Lee, Hyun-Seok Park   +2 more
doaj   +1 more source

In silico analysis of promoter region and regulatory elements of glucan endo-1,3-beta-glucosidase encoding genes in Solanum tuberosum: cultivar DM 1-3 516 R44

Journal of Genetic Engineering and Biotechnology, 2021
Background Potato (Solanum tuberosum L.) is one of the most important food crops in the world. Pathogens remain as one of the major constraints limiting potato productivity.
Atnafu Kebede, Mulugeta Kebede
doaj   +1 more source

Genetic effect of an InDel in the promoter region of the NUDT15 and its effect on myoblast proliferation in chickens [PDF]

BMC Genomics, 2022
Abstract Background Molecular breeding accelerates the speed of animal breeding. Screening molecular markers that can affect economic traits through genome-wide association studies (GWAS) can provide a theoretical basis for molecular breeding.
Chengjie Wei, Yufang Niu, Bingjie Chen, Panpan Qin, Yanxing Wang, Dan Hou, Tong Li, Ruiting Li, Chunxiu Wang, Huadong Yin, Ruili Han, Huifen Xu, Yadong Tian, Xiaojun Liu, Xiangtao Kang, Zhuanjian Li   +15 more
openaire   +3 more sources

DNA structural and physical properties reveal peculiarities in promoter sequences of the bacterium Escherichia coli K-12

SN Applied Sciences, 2021
The gene transcription of bacteria starts with a promoter sequence being recognized by a transcription factor found in the RNAP enzyme, this process is assisted through the conservation of nucleotides as well as other factors governing these intergenic ...
Gustavo Sganzerla Martinez, Scheila de Ávila e Silva, Aditya Kumar, Ernesto Pérez-Rueda   +3 more
doaj   +1 more source

Genetic variant in theHSPB1 promoter region impairs the HSP27 stress response [PDF]

Human Mutation, 2007
The 27 kDa heat shock protein 1 (HSP27) is a member of the ubiquitously expressed small heat shock protein family and has pleiotropic cytoprotective functions. Since HSP27 may act as a motor neuron survival factor, we analyzed the genetic contribution of the human HSPB1 gene (HSPB1) to the etiology of amyotrophic lateral sclerosis (ALS). In a cohort of
Dierick, Ines, Irobi-Devolder, Joy, Janssens, Sophie, Theuns, Jessie, Lemmens, Robin, Jacobs, An, Corsmit, Ellen, Hersmus, Nicole, van den Bosch, Ludo, Robberecht, Wim, De Jonghe, Peter, Van Broeckhoven, Christine, Timmerman, Vincent   +12 more
openaire   +4 more sources

Clinical Implications of Genetic Variation in the Serotonin Transporter Promoter Region [PDF]

The Primary Care Companion to The Journal of Clinical Psychiatry, 2009
To determine the state of the art in understanding the role of genetic variation in the serotonin transporter (5-HTT) promoter region (5-HTTLPR) in the development of a depressive episode and in its response to treatment.PubMed and Ovid were used to search for articles published prior to December 2007 utilizing the key words serotonin transporter, 5 ...
Margaret Husk, Nicole S. Luddington, Rif S. El-Mallakh, Anitha Mandadapu   +3 more
openaire   +3 more sources

Detection of rare genetic variations in the promoter regions of the ATG16L gene in Parkinson's patients

Neuroscience Letters, 2023
Mutations in the ATG genes have been related to impair autophagic function, contributing to the sporadic onset of Parkinsońs Disease (PD). However, scarce studies have been performed about ins/del within the regulatory domains of the autophagy genes in sporadic PD patients. This study was aimed to found ins/del within part of the crucial core autophagy
Gómez Martín, Ana María, Fuentes Rodríguez, José Manuel, Jordán Bueso, Joaquín, Galindo Anaya, María Francisca, Fernández García, José Luis   +4 more
openaire   +4 more sources