Results 1 to 10 of about 795,608 (343)
Genetic recombination is targeted towards gene promoter regions in dogs. [PDF]
PLoS Genetics, 2013 The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals.
Adam Auton +12 more
doaj +20 more sources
Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi [PDF]
BMC Gastroenterology, 2006 Background Hepatitis B virus (HBV) genotypes have distinct geographic distribution. Moreover, much genetic variability has been described in the precore (PC) and basal core promoter (BCP) regions of the HBV genome.
Naqvi Syed +4 more
doaj +5 more sources
Pharmaceuticals, 2021 E-cadherin is a key player in gastric cancer (GC) and germline alterations of CDH1, its encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome. This study aimed at elucidating the role of genetic variants and DNA methylation
Gianluca Tedaldi +18 more
doaj +2 more sources
Journal of Genetic Engineering and Biotechnology, 2021 Background Potato (Solanum tuberosum L.) is one of the most important food crops in the world. Pathogens remain as one of the major constraints limiting potato productivity.
Atnafu Kebede, Mulugeta Kebede
doaj +2 more sources
BMC Bioinformatics, 2008 Background Analysis of single nucleotide polymorphism (SNP) is becoming a key research in genomics fields. Many functional analyses of SNPs have been carried out for coding regions and splicing sites that can alter proteins and mRNA splicing.
Chung Won-Hyong +5 more
doaj +2 more sources
DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.
PLoS ONE, 2017 The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying complexes and thereby regulates the expression of a large number of genes.
Mads Dyrvig +6 more
doaj +2 more sources
Building the Frequency Profile of the Core Promoter Element Patterns in the Three ChromHMM Promoter States at 200bp Intervals: A Statistical Perspective [PDF]
Genomics & Informatics, 2015 Recently, the Encyclopedia of DNA Elements (ENCODE) Analysis Working Group converted data from ChIP-seq analyses from the Broad Histone track into 15 corresponding chromatic maps that label sequences with different kinds of histone modifications in ...
Heather Lent +2 more
doaj +1 more source
Nature Cancer, 2023 Bispecific antibodies targeting GPRC5D demonstrated promising efficacy in multiple myeloma, but acquired resistance usually occurs within a few months. Using a single-nucleus multi-omic strategy in three patients from the MYRACLE cohort (ClinicalTrials ...
J. Derrien +13 more
semanticscholar +1 more source
SN Applied Sciences, 2021 The gene transcription of bacteria starts with a promoter sequence being recognized by a transcription factor found in the RNAP enzyme, this process is assisted through the conservation of nucleotides as well as other factors governing these intergenic ...
Gustavo Sganzerla Martinez +3 more
doaj +1 more source
Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation
Frontiers in Genome Editing, 2023 DNA regulatory elements intricately control when, where, and how genes are activated. Therefore, understanding the function of these elements could unveil the complexity of the genetic regulation network.
Jeong Hoon Han +3 more
doaj +1 more source