Results 21 to 30 of about 795,608 (343)
Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer [PDF]
BioMed Research International, 2017 Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related
Jiaping Chen +9 more
openaire +3 more sources
Transcriptional analysis of the human PAX9 promoter
Journal of Applied Oral Science, 2010 OBJECTIVES: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme.
Carolina Vieira de Almeida +4 more
doaj +1 more source
Functional analysis of recurrent CDC20 promoter variants in human melanoma
Communications Biology, 2023 Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks.
Paula M. Godoy +7 more
doaj +1 more source
International Journal of Molecular Sciences, 2018 Signal transducer and activator of transcription 3 (STAT3) plays a critical role in leptin-mediated regulation of energy metabolism. This study investigated genetic variation in STAT3 promoter regions and verified their contribution to bovine body size ...
Sen Wu +9 more
semanticscholar +1 more source
Frontiers in Psychology, 2014 The molecular mechanism of olfactory cognition is very complicated. Olfactory cognition is initiated by olfactory receptor proteins (odorant receptors), which are activated by olfactory stimuli (ligands). Olfactory receptors are the initial player in the
E. Ignatieva +4 more
semanticscholar +1 more source
Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers [PDF]
Oxidative Medicine and Cellular Longevity, 2020 The genetic polymorphism in the nuclear factor erythroid 2-related factor 2 (Nrf2) gene has been reported as one of the prognosis markers for various diseases, including cancer. Nrf2 is a key transcription factor involved in wound healing by regulating angiogenesis.
Rajan Teena +4 more
openaire +3 more sources
Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells
Frontiers in Genetics, 2018 The MALAT1 long noncoding RNA is strongly linked to cancer progression. Here we report a MALAT1 function in repressing the promoter of p53 (TP53) tumor suppressor gene.
Keiko Tano +6 more
doaj +1 more source
Variation in the flowering time orthologs BrFLC and BrSOC1 in a natural population of Brassica rapa. [PDF]
, 2015 Understanding the genetic basis of natural phenotypic variation is of great importance, particularly since selection can act on this variation to cause evolution.
Franks, Steven J +7 more
core +2 more sources
Polimorfismos en el gen promotor de IL-10 en una muestra de pacientes colombianos con lepra
Biomédica: revista del Instituto Nacional de Salud, 2012 Introducción. Se han reportado polimorfismos en los genes promotores que codifican para citocinas y que afectan los niveles de transcripción, con implicaciones clínicas y funcionales en pacientes con lepra. Objetivo.
Nora Cardona-Castro +3 more
doaj +1 more source
Current Issues in Molecular Biology, 2021 DNA methylation and the alternative splicing of precursor messenger RNAs (pre-mRNAs) are two important genetic modification mechanisms. However, both are currently uncharacterized in the muscle metabolism of rabbits. Thus, we constructed the Tianfu black
Yanhong Li +10 more
doaj +1 more source