Results 21 to 30 of about 552,746 (191)
Tipping the Balance: a criticality perspective [PDF]
Entropy 24, 405 (2022), 2023 Cell populations are often characterised by phenotypic heterogeneity in the form of two distinct subpopulations. We consider a model of tumour cells consisting of two subpopulations: non-cancer promoting (NCP) and cancer-promoting (CP). Under steady state conditions, the model has similarities with a well-known model of population genetics which ...
arxiv +1 more source
Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells
Frontiers in Genetics, 2018 The MALAT1 long noncoding RNA is strongly linked to cancer progression. Here we report a MALAT1 function in repressing the promoter of p53 (TP53) tumor suppressor gene.
Keiko Tano +6 more
doaj +1 more source
Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers [PDF]
Oxidative Medicine and Cellular Longevity, 2020 The genetic polymorphism in the nuclear factor erythroid 2-related factor 2 (Nrf2) gene has been reported as one of the prognosis markers for various diseases, including cancer. Nrf2 is a key transcription factor involved in wound healing by regulating angiogenesis.
Rajan Teena +4 more
openaire +3 more sources
Polimorfismos en el gen promotor de IL-10 en una muestra de pacientes colombianos con lepra
Biomédica: revista del Instituto Nacional de Salud, 2012 Introducción. Se han reportado polimorfismos en los genes promotores que codifican para citocinas y que afectan los niveles de transcripción, con implicaciones clínicas y funcionales en pacientes con lepra. Objetivo.
Nora Cardona-Castro +3 more
doaj +1 more source
Stress-induced duplex destabilization (SIDD) profiles for T7 bacteriophage promoters [PDF]
Компьютерные исследования и моделирование, 2018 The functioning of DNA regulatory regions rely primarily on their physicochemical and structural properties but not on nucleotide sequences, i.e. genetic text.
Mikhail Anatolievich Orlov +4 more
doaj +1 more source
Current Issues in Molecular Biology, 2021 DNA methylation and the alternative splicing of precursor messenger RNAs (pre-mRNAs) are two important genetic modification mechanisms. However, both are currently uncharacterized in the muscle metabolism of rabbits. Thus, we constructed the Tianfu black
Yanhong Li +10 more
doaj +1 more source
Genetic drift opposes mutualism during spatial population expansion [PDF]
Proc. Natl. Acad. Sci. USA 111, 1037-1042 (2014), 2014 Mutualistic interactions benefit both partners, promoting coexistence and genetic diversity. Spatial structure can promote cooperation, but spatial expansions may also make it hard for mutualistic partners to stay together, since genetic drift at the expansion front creates regions of low genetic and species diversity. To explore the antagonism between
arxiv +1 more source
Journal of Kidney Cancer and VHL, 2021 The aim of the present study was to investigate the rs1800468 (G-800A), rs1800469 (C-509T), rs1800470 (C29T), and rs1800471 (G74C) TGFB1 genetic polymorphisms and their haplotype structures in patients with Wilms Tumor (WT) and neoplasia-free controls.
Cintya Mayumi Ishibashi +10 more
openaire +5 more sources
Interaction between non-coding RNAs, mRNAs and G-quadruplexes
Cancer Cell International, 2022 G-quadruplexes are secondary helical configurations established between guanine-rich nucleic acids. The structure is seen in the promoter regions of numerous genes under certain situations.
Soudeh Ghafouri-Fard +6 more
doaj +1 more source
Genetic analysis of the dsz promoter and associated regulatory regions of Rhodococcus erythropolis IGTS8 [PDF]
Journal of Bacteriology, 1996 The dsz gene cluster of Rhodococcus erythropolis IGTS8 comprises three genes, dszA, dszB, and dszC, whose products are involved in the conversion of dibenzothiophene (DBT) to 2-hydroxybiphenyl and sulfite. This organism can use DBT as the sole sulfur source but not as a carbon source.
J D Childs +3 more
openaire +3 more sources