Results 41 to 50 of about 552,746 (191)

Molecular characterization of the giant freshwater prawn (Macrobrachium rosenbergii) beta-actin gene promoter [PDF]

PeerJ, 2018
Constitutive promoters are important tools for gene function studies and transgenesis. The Beta-actin (actb1) gene promoter has been isolated from many species but remains to be cloned from the giant freshwater prawn (Macrobrachium rosenbergii).
Junjun Yan, Qiang Gao, Zongbin Cui, Guoliang Yang, Yong Long   +4 more
doaj   +2 more sources

Mechanisms underlying the tissue-specific and regulated activity of the Gnrhr promoter in mammals.

Frontiers in Endocrinology, 2012
The GnRH receptor (GnRHR) plays a central role in the development and maintenance of reproductive function in mammals. Following stimulation by GnRH originating from the hypothalamus, GnRHR triggers multiple signalling events that ultimately stimulate ...
Anne-Laure eSchang, Bruno eQuérat, Violaine eSimon, Ghislaine eGarrel, Christian eBleux, Raymond eCounis, Joëlle eCohen-Tannoudji, Jean-Noël eLaverrière   +7 more
doaj   +1 more source

Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation

Communications Biology, 2023
G-quadruplexes (G4s) regulate DNA replication and gene transcription, and are enriched in promoters without fully appreciated functional relevance.
Guangyue Li, Gongbo Su, Yunxuan Wang, Wenmeng Wang, Jinming Shi, Dangdang Li, Guangchao Sui   +6 more
doaj   +1 more source

Coarse-Grained Modeling of Genetic Circuits as a Function of the Inherent Time Scales [PDF]

Phys. Rev. E 87, 062706 (2013), 2012
From a coarse-grained perspective the motif of a self-activating species, activating a second species which acts as its own repressor, is widely found in biological systems, in particular in genetic systems with inherent oscillatory behavior. Here we consider a specific realization of this motif as a genetic circuit, in which genes are described as ...
arxiv   +1 more source

SNP@Promoter: a database of human SNPs (Single Nucleotide Polymorphisms) within the putative promoter regions

BMC Bioinformatics, 2008
Background Analysis of single nucleotide polymorphism (SNP) is becoming a key research in genomics fields. Many functional analyses of SNPs have been carried out for coding regions and splicing sites that can alter proteins and mRNA splicing.
Chung Won-Hyong, Park Daeui, Kim Woo-Yeon, Kim Byoung-Chul, Shin Kwang-sik, Bhak Jong   +5 more
doaj   +1 more source

Associations between novel genetic variants in the promoter region ofMALAT1and risk of colorectal cancer [PDF]

Oncotarget, 2017
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-known long non-coding RNA, is involved in pathogenesis and progress of multiple tumors. However, no study has been performed to investigate the relationship between the genetic variants in promoter region of MALAT1 and colorectal cancer risk.
Fangyuan Jing, Chunhong Fan, Ding Ye, Chengzhen Bao, Simeng Gu, Mingjuan Jin, Kun Chen, Yingjun Li   +7 more
openaire   +3 more sources

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

Nature Communications, 2017
Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and ...
Romina Petersen, John J. Lambourne, Biola M. Javierre, Luigi Grassi, Roman Kreuzhuber, Dace Ruklisa, Isabel M. Rosa, Ana R. Tomé, Heather Elding, Johanna P. van Geffen, Tao Jiang, Samantha Farrow, Jonathan Cairns, Abeer M. Al-Subaie, Sofie Ashford, Antony Attwood, Joana Batista, Heleen Bouman, Frances Burden, Fizzah A. Choudry, Laura Clarke, Paul Flicek, Stephen F. Garner, Matthias Haimel, Carly Kempster, Vasileios Ladopoulos, An-Sofie Lenaerts, Paulina M. Materek, Harriet McKinney, Stuart Meacham, Daniel Mead, Magdolna Nagy, Christopher J. Penkett, Augusto Rendon, Denis Seyres, Benjamin Sun, Salih Tuna, Marie-Elise van der Weide, Steven W. Wingett, Joost H. Martens, Oliver Stegle, Sylvia Richardson, Ludovic Vallier, David J. Roberts, Kathleen Freson, Lorenz Wernisch, Hendrik G. Stunnenberg, John Danesh, Peter Fraser, Nicole Soranzo, Adam S. Butterworth, Johan W. Heemskerk, Ernest Turro, Mikhail Spivakov, Willem H. Ouwehand, William J. Astle, Kate Downes, Myrto Kostadima, Mattia Frontini   +58 more
doaj   +1 more source

A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions. [PDF]

PLoS ONE, 2016
Comprehensive delineation of complex cellular networks requires high-throughput interrogation of genetic interactions. To address this challenge, we describe the development of a multiplex combinatorial strategy to assess pairwise genetic interactions ...
Victoria B Stockman, Lila Ghamsari, Gorka Lasso, Barry Honig, Sagi D Shapira, Harris H Wang   +5 more
doaj   +1 more source

Statistically Significant Strings are Related to Regulatory Elements in the Promoter Regions of Saccharomyces cerevisiae [PDF]

, 2000
Finding out statistically significant words in DNA and protein sequences forms the basis for many genetic studies. By applying the maximal entropy principle, we give one systematic way to study the nonrandom occurrence of words in DNA or protein sequences.
arxiv   +1 more source

Two Cellular Resource Based Models Linking Growth and Parts Characteristics Aids the Study and Optimization of Synthetic Gene Circuits [PDF]

Engineering Biology 1(1): 30-39 (2017), 2023
A major challenge in synthetic genetic circuit development is the inter-dependency between heterologous gene expressions by circuits and host's growth rate. Increasing heterologous gene expression increases burden to the host, resulting in host growth reduction; which reduces overall heterologous protein abundance.
arxiv