Functional Characterization of Genetic Polymorphisms Identified in the Promoter Region of the BovinePEPSGene [PDF]
DNA and Cell Biology, 2012 Peptidase S (PEPS) is a metallopeptidase that cleaves N-terminal residues from proteins and peptides. PEPS is used as a cell maintenance enzyme with critical roles in peptide turnover. The promoter region located upstream of the initiation site plays an important role in regulating gene expression.
Zhihua, Ju +7 more
openaire +2 more sources
Mechanisms underlying the tissue-specific and regulated activity of the Gnrhr promoter in mammals.
Frontiers in Endocrinology, 2012 The GnRH receptor (GnRHR) plays a central role in the development and maintenance of reproductive function in mammals. Following stimulation by GnRH originating from the hypothalamus, GnRHR triggers multiple signalling events that ultimately stimulate ...
Anne-Laure eSchang +7 more
doaj +1 more source
Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting [PDF]
, 2015 Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (
Alsop, Amber +12 more
core +1 more source
Positive selection in coding regions and motif duplication in regulatory regions of bottlenose dolphin MHC class II genes. [PDF]
PLoS ONE, 2018 The vertebrate immune response is mediated through highly adaptive, quickly evolving cell surface receptors, the major histocompatibility complex (MHC).
Heidi J T Pagán +2 more
doaj +1 more source
Natural variation in abiotic stress responsive gene expression and local adaptation to climate in Arabidopsis thaliana. [PDF]
, 2014 Gene expression varies widely in natural populations, yet the proximate and ultimate causes of this variation are poorly known. Understanding how variation in gene expression affects abiotic stress tolerance, fitness, and adaptation is central to the ...
Des Marais, David L +7 more
core +2 more sources
Promoter trapping in microalgae using the antibiotic paromomycin as selective agent [PDF]
, 2012 The lack of highly active endogenous promoters to drive the expression of transgenes is one of the main drawbacks to achieving efficient transformation of many microalgal species.
Díaz Santos, Encarnación +5 more
core +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine +10 more
wiley +1 more source
Molecular characterization of the giant freshwater prawn (Macrobrachium rosenbergii) beta-actin gene promoter [PDF]
PeerJ, 2018 Constitutive promoters are important tools for gene function studies and transgenesis. The Beta-actin (actb1) gene promoter has been isolated from many species but remains to be cloned from the giant freshwater prawn (Macrobrachium rosenbergii).
Junjun Yan +4 more
doaj +2 more sources
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. [PDF]
, 2019 Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward productive elongation.
Ablondi, Eileen +20 more
core +1 more source
Epigenetic aberrations and cancer [PDF]
, 2006 The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core +3 more sources