Results 41 to 50 of about 795,608 (343)

A sigma factor toolbox for orthogonal gene expression in Escherichia coli [PDF]

, 2018
Synthetic genetic sensors and circuits enable programmable control over timing and conditions of gene expression and, as a result, are increasingly incorporated into the control of complex and multi-gene pathways.
Bervoets, Indra, Charlier, Daniel, De Mey, Marjan, Maertens, Jo, Van Brempt, Maarten, Van Hove, Bob, Van Nerom, Katleen   +6 more
core   +4 more sources

Genetic Dissection of the Light-InduciblecarQRSPromoter Region ofMyxococcus xanthus [PDF]

Journal of Bacteriology, 2004
ABSTRACTInMyxococcus xanthusphotoprotective carotenoids are produced in response to illumination due to regulated expression of carotenoid biosynthesis genes at two loci. Induction of the carotenogenesis regulon is dependent on expression of thecarQRSoperon.
David A. Hodgson, Samantha J. Bryan, David E. Whitworth, Andrew Berry, Simon J. McGowan   +4 more
openaire   +3 more sources

Construction and characterization of a synthetic Baculovirus-inducible 39K promoter

Journal of Biological Engineering, 2018
Background Silkworm genetic engineering is widely used in gene function, silk engineering and disease-resistant engineering in most of Asia. Some of the earliest promoter elements are used to control the development of silkworm transgenic expression and ...
Zhan-Qi Dong, Zhi-Gang Hu, Hai-Qing Li, Ya-Ming Jiang, Ming-Ya Cao, Peng Chen, Cheng Lu, Min-Hui Pan   +7 more
doaj   +1 more source

Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness? [PDF]

, 2010
In the past few years, numerous research projects have focused on identifying and understanding scaling properties in the gene content of prokaryote genomes and the intricacy of their regulation networks.
Adami, Balleza, C. Knibbe, Cases, Cordero, D.P. Parsons, Dittrich, Drake, Drake, Elena, Foster, G. Beslon, Itzkovitz, J.-M. Peña, Janga, Knibbe, Knibbe, Knibbe, Konstantinidis, Koonin, Lenski, Luscombe, Maslov, Molina, Molina, Nehaniv, Pepper, Reymond, Sniegowski, Stover, Struhl, van Nimwegen, Viñuelas, Wagner, West, West, Wilke, Y. Sanchez-Dehesa   +37 more
core   +4 more sources

The effect of genetic variation on promoter usage and enhancer activity

Nature Communications, 2017
The identification of genetic variants affecting gene expression, namely expression quantitative trait loci (eQTLs), has contributed to the understanding of mechanisms underlying human traits and diseases. The majority of these variants map in non-coding
M. Garieri, O. Delaneau, F. Santoni, R. Fish, David Mull, Piero Carninci, E. Dermitzakis, S. Antonarakis, A. Fort   +8 more
semanticscholar   +1 more source

Promoter trapping in microalgae using the antibiotic paromomycin as selective agent [PDF]

, 2012
The lack of highly active endogenous promoters to drive the expression of transgenes is one of the main drawbacks to achieving efficient transformation of many microalgal species.
Díaz Santos, Encarnación, León, Rosa, Rodríguez Martínez, Herminia, Vargas Muñoz, María de los Ángeles, Vega Naranjo, Marta de La, Vila Spinola, Marta   +5 more
core   +3 more sources

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

Science, 2019
Linking enhancers to disease Enhancers are genomic regions that regulate gene expression, sometimes in a cell-dependent manner. However, most of our knowledge of human brain cell–type enhancers derives from studies of bulk human brain tissue. Nott et al.
A. Nott, I. Holtman, N. Coufal, J. Schlachetzki, Miao Yu, Rong Hu, Claudia Z. Han, Monique Pena, Jiayang Xiao, Yin Wu, Zahara Keulen, M. Pasillas, Carolyn O’Connor, C. Nickl, Simon T. Schafer, Zeyang Shen, R. Rissman, J. Brewer, D. Gosselin, D. Gonda, M. Levy, M. Rosenfeld, G. McVicker, F. Gage, B. Ren, C. Glass   +25 more
semanticscholar   +1 more source

Synthetic biology: advancing biological frontiers by building synthetic systems [PDF]

, 2012
Advances in synthetic biology are contributing to diverse research areas, from basic biology to biomanufacturing and disease therapy.
Chen, Yvonne Y., Galloway, Kate E., Smolke, Christina D.   +2 more
core   +5 more sources

BDNF promoter methylation and genetic variation in late-life depression

Translational Psychiatry, 2015
The regulation of the brain-derived neurotrophic factor (BDNF) is important for depression pathophysiology and epigenetic regulation of the BDNF gene may be involved. This study investigated whether BDNF methylation is a marker of depression.
Vania Januar, M. Ancelin, K. Ritchie, R. Saffery, Joanne Ryan   +4 more
semanticscholar   +1 more source

Positive selection in coding regions and motif duplication in regulatory regions of bottlenose dolphin MHC class II genes. [PDF]

PLoS ONE, 2018
The vertebrate immune response is mediated through highly adaptive, quickly evolving cell surface receptors, the major histocompatibility complex (MHC).
Heidi J T Pagán, Tatiana Ferrer, Greg O'Corry-Crowe   +2 more
doaj   +1 more source