Results 51 to 60 of about 795,608 (343)

Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone [PDF]

, 2012
We performed a genetic association study of rare variants and single nucleotide polymorphisms (SNPs) of UCMA/GRP and OPTN genes, in French-Canadian patients with Paget's disease of bone (PDB) and in healthy controls from the same population.
Albagha, Albagha, Avilion, Basu-Roy, Cancela, Chen, Chung, Desmet, Edith Gagnon, Ethel S. Siris, Fahmi, Gabriel Miltenberger-Miltenyi, Goode, Hocking, Jacques P. Brown, Jean Morissette, Laurin, Laurin, Layfield, Laëtitia Michou, Le Jeune, Lefebvre, Lucas, Luu-The, M. Leonor Cancela, Maruyama, Michou, Morissette, Natércia Conceição, Pankiv, Rath, Rezaie, Rousiere, Shankar, Singh, Staden, Surmann-Schmitt, Tagariello, Tong, van Staa, Viegas, Viegas   +41 more
core   +1 more source

SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. [PDF]

, 2015
Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity.
Chen, Xuemei, Gao, Lei, Kim, Yun Ju, Li, Shaofang, Li, Shengben, Liu, Lin, Zhao, Yuanyuan   +6 more
core   +2 more sources

Association between Polymorphisms in the Promoter Regions of Matrix Metalloproteinases (MMPs) and Risk of Cancer Metastasis: A Meta-Analysis

PLoS ONE, 2012
Background A variety of studies have evaluated the associations between polymorphisms in the promoter regions of Matrix metalloproteinases (MMPs) and cancer metastasis. However, the results remain inconclusive.
Dan Liu, Hong Guo, Yafei Li, Xue-qing Xu, Kang Yang, Yun Bai   +5 more
semanticscholar   +1 more source

Functional Characterization of Genetic Polymorphisms Identified in the Promoter Region of the BovinePEPSGene [PDF]

DNA and Cell Biology, 2012
Peptidase S (PEPS) is a metallopeptidase that cleaves N-terminal residues from proteins and peptides. PEPS is used as a cell maintenance enzyme with critical roles in peptide turnover. The promoter region located upstream of the initiation site plays an important role in regulating gene expression.
Jifeng Zhong, Xue Zheng, Zhihua Ju, Jinming Huang, Yan Zhang, Chao Qi, Jianbin Li, Changfa Wang   +7 more
openaire   +3 more sources

Phase and antigenic variation in mycoplasmas [PDF]

, 2010
With their reduced genome bound by a single membrane, bacteria of the Mycoplasma species represent some of the simplest autonomous life forms. Yet, these minute prokaryotes are able to establish persistent infection in a wide range of hosts, even in the ...
Baranowski, Eric, Citti, Christine, Nouvel, Laurent-Xavier   +2 more
core   +2 more sources

Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder

Science, 2018
INTRODUCTION The DNA of protein-coding genes is transcribed into mRNA, which is translated into proteins. The “coding genome” describes the DNA that contains the information to make these proteins and represents ~1.5% of the human genome.
Joon-Yong An, K. Lin, Lingxue Zhu, Donna M. Werling, Shan Dong, H. Brand, Harold Wang, Xuefang Zhao, Grace B. Schwartz, Ryan L. Collins, Benjamin Currall, Claudia Dastmalchi, Jeanselle Dea, Clif Duhn, Michael C. Gilson, L. Klei, Lindsay Liang, Eirene Markenscoff-Papadimitriou, Sirisha Pochareddy, N. Ahituv, J. Buxbaum, H. Coon, M. Daly, Young Shin Kim, Gabor T. Marth, B. Neale, A. Quinlan, J. Rubenstein, N. Šestan, M. State, A. Willsey, M. Talkowski, B. Devlin, K. Roeder, Stephan J Sanders   +34 more
semanticscholar   +1 more source

Mechanisms underlying the tissue-specific and regulated activity of the Gnrhr promoter in mammals.

Frontiers in Endocrinology, 2012
The GnRH receptor (GnRHR) plays a central role in the development and maintenance of reproductive function in mammals. Following stimulation by GnRH originating from the hypothalamus, GnRHR triggers multiple signalling events that ultimately stimulate ...
Anne-Laure eSchang, Bruno eQuérat, Violaine eSimon, Ghislaine eGarrel, Christian eBleux, Raymond eCounis, Joëlle eCohen-Tannoudji, Jean-Noël eLaverrière   +7 more
doaj   +1 more source

Molecular characterization of the giant freshwater prawn (Macrobrachium rosenbergii) beta-actin gene promoter [PDF]

PeerJ, 2018
Constitutive promoters are important tools for gene function studies and transgenesis. The Beta-actin (actb1) gene promoter has been isolated from many species but remains to be cloned from the giant freshwater prawn (Macrobrachium rosenbergii).
Junjun Yan, Qiang Gao, Zongbin Cui, Guoliang Yang, Yong Long   +4 more
doaj   +2 more sources

Possible consequences of the overlap between the CaMV 35S promoter regions in plant transformation vectors used and the viral gene VI in transgenic plants.

GM crops & food, 2012
Multiple variants of the Cauliflower mosaic virus 35S promoter (P35S) are used to drive the expression of transgenes in genetically modified plants, for both research purposes and commercial applications.
N. Podevin, P. du Jardin
semanticscholar   +1 more source

Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation

Communications Biology, 2023
G-quadruplexes (G4s) regulate DNA replication and gene transcription, and are enriched in promoters without fully appreciated functional relevance.
Guangyue Li, Gongbo Su, Yunxuan Wang, Wenmeng Wang, Jinming Shi, Dangdang Li, Guangchao Sui   +6 more
doaj   +1 more source