Results 81 to 90 of about 595,995 (298)

Design, modeling and synthesis of an in vitro transcription rate regulatory circuit [PDF]

, 2008
This paper describes the design, modeling and realization of a synthetic in vitro circuit that aims at regulating the rate of mRNA transcription. Two DNA templates are designed to interact through their transcripts, creating negative feedback loops that ...
Forsberg, Per-Ola, Franco, Elisa, Murray, Richard M.   +2 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions. [PDF]

PLoS ONE, 2016
Comprehensive delineation of complex cellular networks requires high-throughput interrogation of genetic interactions. To address this challenge, we describe the development of a multiplex combinatorial strategy to assess pairwise genetic interactions ...
Victoria B Stockman, Lila Ghamsari, Gorka Lasso, Barry Honig, Sagi D Shapira, Harris H Wang   +5 more
doaj   +1 more source

Distributed classifier based on genetically engineered bacterial cell cultures

, 2014
We describe a conceptual design of a distributed classifier formed by a population of genetically engineered microbial cells. The central idea is to create a complex classifier from a population of weak or simple classifiers.
Didovyk, Andriy, Hasty, Jeff, Huerta, Ramón, Ivanchenko, Mikhail V., Kanakov, Oleg I., Tsimring, Lev   +5 more
core   +2 more sources

Complexities associated with expression of Epstein-Barr virus (EBV) lytic origins of DNA replication. [PDF]

, 2007
EBV has two lytic origins (oriLyt) of DNA replication lying at divergent sites on the viral genome within a duplicated sequence (DS). The latter contains potential hairpin loops, ‘hinge’ elements and the promoters for transcripts from viral genes BHLF1 ...
Griffin, BE, Xue, SA
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Genetic Variation in the Promoter Region of Chitinase 3-Like 1 Is Associated with Atopy

American Journal of Respiratory and Critical Care Medicine, 2009
Atopy or atopic syndrome is an allergic hypersensitivity subject to hereditary influences. Aberrant expression of chitinase 3-like 1 (CHI3L1), also known as YKL-40 or HC gp-39, is involved in the pathogenesis of inflammatory and allergic diseases.The genetic contribution of CHI3L1 gene to atopic susceptibility was investigated using an integrated ...
Myung Hyun, Sohn, Ji Hyun, Lee, Kyung Won, Kim, So Won, Kim, Sung Hee, Lee, Kyu-Earn, Kim, Kyung Hwan, Kim, Chun Geun, Lee, Jack A, Elias, Min Goo, Lee   +9 more
openaire   +3 more sources

Genetic polymorphisms in the 5' flanking region of glutathione S-transferase P1 affect promoter methylation [PDF]

Breast Cancer Research, 2005
Glutathione-S-transferase P1 (GSTP1) is involved in thiol-mediated detoxification and breakdown of reactive oxygen species created by anticancer drug exposure. GSTP1 is also an inhibitor of c-Jun N-terminal kinase 1, a kinase involved in stress response, apoptosis and cellular proliferation.
Rønneberg, JA, Tost, J, Grenaker-Alnæs, GI, Sørlie, T, Kristensen, T, Gut, I, Børresen-Dale, A-L, Kristensen, VN   +7 more
openaire   +1 more source

Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption

BMC Gastroenterology, 2022
Background While role of ALDOB-related gene variants for hereditary fructose intolerance is well established, contribution of gene variants for acquired fructose malabsorption (e.g. SLC2A5, GLUT5) is not well understood.
Irina Taneva, Dorothee Grumann, Dietmar Schmidt, Elina Taneva, Ulrike von Arnim, Thomas Ansorge, Thomas Wex   +6 more
doaj   +1 more source

Phase and antigenic variation in mycoplasmas [PDF]

, 2010
With their reduced genome bound by a single membrane, bacteria of the Mycoplasma species represent some of the simplest autonomous life forms. Yet, these minute prokaryotes are able to establish persistent infection in a wide range of hosts, even in the ...
Baranowski, Eric, Citti, Christine, Nouvel, Laurent-Xavier   +2 more
core   +2 more sources