Results 81 to 90 of about 795,608 (343)

Host and Viral Genetic Variation in HBV-Related Hepatocellular Carcinoma

Frontiers in Genetics, 2018
Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and the second leading cause of cancer deaths globally. The high prevalence of HCC is due in part to the high prevalence of chronic HBV infection and the high mortality rate is due to ...
P. An, Jinghang Xu, Yanyan Yu, C. Winkler   +3 more
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption

BMC Gastroenterology, 2022
Background While role of ALDOB-related gene variants for hereditary fructose intolerance is well established, contribution of gene variants for acquired fructose malabsorption (e.g. SLC2A5, GLUT5) is not well understood.
Irina Taneva, Dorothee Grumann, Dietmar Schmidt, Elina Taneva, Ulrike von Arnim, Thomas Ansorge, Thomas Wex   +6 more
doaj   +1 more source

Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Nature Communications, 2016
Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly-diagnosed IBD cases and 190 controls.
N. Ventham, N. Kennedy, A. Adams, R. Kalla, S. Heath, K. O’Leary, H. Drummond, Gordan Harry Dermot P. B. Vito Vlatka Iain K. Manfred Dan Lauc Campbell McGovern Annese Zoldoš Permberton Wu, G. Lauc, Harry Campbell, D. McGovern, V. Annese, V. Zoldoš, Iain K. Permberton, M. Wuhrer, D. Kolarich, D. Fernandes, Evropi Theorodorou, Victoria Merrick, D. Spencer, Richard A Gardner, R. Doran, Archana Shubhakar, R. Boyapati, I. Rudan, P. Lionetti, I. Akmačić, Jasminka Krištić, F. Vučković, J. Štambuk, M. Novokmet, M. Pučić-Baković, O. Gornik, A. Andriulli, L. Cantoro, G. Sturniolo, G. Fiorino, Natalia Manetti, A. Latiano, A. Kohn, R. D'Incà, S. Danese, I. Arnott, C. Noble, C. Lees, A. Shand, G. Ho, M. Dunlop, L. Murphy, J. Gibson, L. Evenden, N. Wrobel, T. Gilchrist, A. Fawkes, Guinevere S M Kammeijer, F. Clerc, N. de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, P. Dobrinić, Y. Aulchenko, Tim van den Heuve, D. Jonkers, M. Pierik, Simen Petr Jørgen Panpan Janne Anna B. Tone M. Aina E. F Vatn Ricanek Jahnsen You Sølvernes Frengen Tannæs , S. Vatn, P. Ricanek, J. Jahnsen, Panpan You, Janne Sølvernes, Anna Frengen, T. Tannæs, A. E. Moen, Fredrik A. Dahl, J. Lindstrøm, G. S. Ekeland, T. Detlie, Å. Keita, J. Söderholm, H. Hjortswang, J. Halfvarson, D. Bergemalm, F. Gomollón, Mauro D’Amato, L. Törkvist, F. Hjelm, M. Gullberg, N. Nordberg, A. Ocklind, E. Pettersson, Daniel Ekman, M. Sundell, E. Modig, Anne-Clémence Veillard, Renaud Schoemans, Dominique M. Poncelet, C. Sabatel, M. Gut, M. Bayés, C. Casén, T. Lindahl, E. Ciemniejewska, M. Vatn, D. Wilson, I. Gut, E. Nimmo, J. Satsangi   +108 more
semanticscholar   +1 more source

A genetic variation of the p38β promoter region is correlated with an increased risk of sporadic colorectal cancer

Oncology Letters, 2013
p38 plays a critical role in the proliferation, survival, migration and metastasis of colorectal cancer (CRC) cells. The present study assessed the correlation between a single nucleotide polymorphism (SNP) in the p38β promoter region (rs2235356, -1628A>G) and the predisposition of individuals to sporadic CRC in a case-control study.
Qinghua Huang, Jiachun Lu, Yisheng Wei, Dianke Chen, Xinhui Fu, Jianping Wang, Shunxin Song, Lei Wang   +7 more
openaire   +4 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

A promoter interaction map for cardiovascular disease genetics

bioRxiv, 2018
Over 500 genetic loci have been associated with risk of cardiovascular diseases (CVDs), however most loci are located in gene-distal non-coding regions and their target genes are not known. Here, we generated high-resolution promoter capture Hi-C (PCHi-C)
L. Montefiori, Débora R. Sobreira, N. Sakabe, I. Aneas, A. Joslin, Grace T. Hansen, G. Bozek, I. Moskowitz, E. McNally, Marcelo Araujo da Nóbrega   +9 more
semanticscholar   +1 more source

Functional and genetic characterization of the promoter region of apolipoprotein H (β₂‐glycoprotein I) [PDF]

The FEBS Journal, 2010
This study characterized the human apolipoprotein H [APOH; β2‐glycoprotein I (β2GPI)] promoter and its variants by in vitro functional experiments and investigated their relationship with human plasma β2GPI levels. We examined the individual effects of 12 APOH promoter single nucleotide polymorphisms in the 5′ flanking region of APOH (∼ 1.4 kb) on ...
Susan Manzi, Sangita Suresh, Candace M. Kammerer, M. Ilyas Kamboh, Rosalind Ramsey-Goldman, F. Yesim Demirci, Iliya Lefterov   +6 more
openaire   +3 more sources

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source