Results 221 to 230 of about 136,204 (260)

Role of Promyelocytic Leukemia Protein in Host Antiviral Defense

Journal of Interferon & Cytokine Research, 2011
Several pathways have been implicated in the establishment of antiviral state in response to interferon (IFN), one of which implicates the promyelocytic leukemia (PML) protein. The PML gene has been discovered 20 years ago and has led to new insights into oncogenesis, apoptosis, cell senescence, and antiviral defense.
M. Geoffroy, M. Chelbi-alix
semanticscholar   +3 more sources

The B-box 1 dimer of human promyelocytic leukemia protein

Journal of Biomolecular NMR, 2014
Shu-Yu Huang, M. Naik, Chi-Fon Chang, Pei-Ju Fang, Ying-Hui Wang, H. Shih, Tai-Huang Huang   +6 more
semanticscholar   +3 more sources

The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN).

Biochimica et biophysica acta. Molecular cell research, 2020
The gene encoding promyelocytic leukemia protein (PML) generates several spliced isoforms. Ectopic expression of PML1 promotes the proliferation of ERα-positive MCF-7 breast cancer (BC) cells, while a loss of PML by knockdown or overexpression of PML4 ...
N. Alhazmi, Chun-Peng Pai, Aljawharah Albaqami, Han Wang, Xuan Zhao, Minyue Chen, Po Hu, Shuang Guo, Kyle A. Starost, Omid Hajihassani, M. Miyagi, H. Kao   +11 more
semanticscholar   +1 more source

Promyelocytic Leukemia Protein, a Protein at the Crossroad of Oxidative Stress and Metabolism

Antioxidants & Redox Signaling, 2017
Cellular metabolic activity impacts the production of reactive oxygen species (ROS), both positively through mitochondrial oxidative processes and negatively by promoting the production of reducing agents (including NADPH and reduced glutathione). A defined metabolic state in cancer cells is critical for cell growth and long-term self-renewal, and such
Sarah Tessier, Natalia Martín-Martín, H. de Thé, A. Carracedo, V. Lallemand-Breitenbach   +4 more
semanticscholar   +4 more sources

Acute promyelocytic leukemia with a PLZF-RARα fusion protein

Seminars in Hematology, 2001
In most cases of acute promyelocytic leukemia (APL), a fusion of the promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha) genes occurs, resulting in the expression of a PML-RARalpha chimeric protein. In approximately 1% of the cases of APL, variant chromosomal aberrations may be found fusing RARa with other genes.
Jansen, J.H., Lowenberg, B.
openaire   +4 more sources

Loss of promyelocytic leukemia protein in human gastric cancers

Cancer Letters, 2007
To clarify the clinical implications of promyelocytic leukemia (PML) expression in gastric carcinomas, the expression of PML was analyzed in large series of gastric carcinoma by immunohistochemistry, western blotting and reverse transcription-PCR. PML protein expression was reduced or abolished in gastric carcinomas (31.7 and 10.6%, respectively) by ...
Hee Eun, Lee, Chang Do, Jee, Min A, Kim, Hye Seung, Lee, You Mie, Lee, Byung Lan, Lee, Woo Ho, Kim   +6 more
openaire   +2 more sources

Acute promyelocytic leukemia and variant fusion proteins: PLZF-RARα fusion protein at a glance.

Seminars in Oncology, 2019
Classical acute promyelocytic leukemia (APL) cases are associated with the promyelocytic leukemia-retinoic acid receptor α (PML-RARα) chimeric fusion protein. Almost all the variant chimeric proteins share the same RARα component. Currently, more than 11
Liaqat Hussain, Yasen Maimaitiyiming, Khairul Islam, Hua Naranmandura   +3 more
semanticscholar   +1 more source

New Powerful Insulin-Like Protein from Human Promyelocytic Leukemia Cells

Endocrinology, 1984
Potent insulin-like activity was found in the conditioned medium of human promyelocytic leukemia (HL-60) cells. The conditioned medium of HL-60 cells at high density stimulated [3H]glucose incorporation into lipids in rat adipocytes in a time- and dose-dependent manner.
T, Yamanouchi, Y, Akanuma, T, Tsushima, K, Shizume, H, Mizoguchi, F, Takaku   +5 more
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Functions and dys-functions of promyelocytic leukemia protein PML

Rendiconti Lincei. Scienze Fisiche e Naturali, 2018
The promyelocytic leukemia protein PML has been previously recognized as a critical and essential regulator of a broad number of cellular functions. At nuclear level PML forms the PML-nuclear bodies, where it can sequester and influence the post-translational modification of a wide number of proteins, ultimately affecting their regulative role in DNA ...
Previati, Maurizio, Missiroli, Sonia, Perrone, Mariasole, Caroccia, Natascia, Paliotto, Federico, Milani, Daniela, Giorgi, Carlotta   +6 more
openaire   +2 more sources

Acute promyelocytic leukemia fusion proteins: up to new tricks

Blood, 2003
In this issue, Kawasaki and colleagues (page [3668][1]) demonstrate that the nuclear-matrix–associated protein, promyelocytic leukemia protein (PML), binds to and inhibits Stat3 transcriptional activity. The region of Stat3 bound by PML includes its DNA binding domain.
openaire   +1 more source