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The PML-RARα Fusion Protein and Targeted Therapy for Acute Promyelocytic Leukemia
Leukemia and Lymphoma, 2004Acute promyelocytic leukemia (APL) is an unique subtype of acute myeloid leukemia typically carrying a specific reciprocal chromosome translocation t(15;17) leading to the expression of a leukemia-generating fusion protein, PML-RARalpha. Nearly all de novo APL patients undergo disease remission when treated with all trans retinoic acid (ATRA) plus ...
Yongkui Jing
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Expert Review of Proteomics, 2010
Protein misfolding has traditionally been linked to the pathogenesis of various neurodegenerative diseases. However, emerging evidence from various laboratories, including ours, suggests that protein misfolding may also play a fundamental role in some malignancies, particularly those caused by fusion oncoprotein generated from chromosomal translocation.
Matiullah Khan
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Protein misfolding has traditionally been linked to the pathogenesis of various neurodegenerative diseases. However, emerging evidence from various laboratories, including ours, suggests that protein misfolding may also play a fundamental role in some malignancies, particularly those caused by fusion oncoprotein generated from chromosomal translocation.
Matiullah Khan
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Functions and dys-functions of promyelocytic leukemia protein PML
Rendiconti Lincei. Scienze Fisiche e Naturali, 2018The promyelocytic leukemia protein PML has been previously recognized as a critical and essential regulator of a broad number of cellular functions. At nuclear level PML forms the PML-nuclear bodies, where it can sequester and influence the post-translational modification of a wide number of proteins, ultimately affecting their regulative role in DNA ...
Previati, Maurizio +6 more
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Proceedings of the National Academy of Sciences of the United States of America
Significance In most cases of acute promyelocytic leukemia (APL), the promyelocytic leukemia-retinoic acid receptor alpha (PML/RARα) fusion protein disrupts PML nuclear bodies and forms PML/RARα microspeckles. However, the assembly mechanism and its role
Yi Zhang +13 more
semanticscholar +1 more source
Significance In most cases of acute promyelocytic leukemia (APL), the promyelocytic leukemia-retinoic acid receptor alpha (PML/RARα) fusion protein disrupts PML nuclear bodies and forms PML/RARα microspeckles. However, the assembly mechanism and its role
Yi Zhang +13 more
semanticscholar +1 more source
Expression of granule protein mRNAs in acute promyelocytic leukemia.
Hematologic pathology, 1994The granule proteins are among the most abundant and characteristic proteins of myeloid cells. They are essential for the antimicrobial activity of these cells and they provide important markers for the differentiation stage of the myeloid series and for the diagnosis of myeloid leukemias.
R K, Hirata, S T, Chen, S C, Weil
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[Research advances on function of promyelocytic leukemia (PML) protein].
Ai zheng = Aizheng = Chinese journal of cancer, 2004Through reviewing research advances on promyelocytic leukemia(PML) protein at home and abroad in recent years, the authors summarized the biological functions of PML protein in this paper. Recent researches indicated that all PML protein isoforms have RBCC (Ring finger domain, B-box, Coiled-Coil domain, RBCC)or TRIM (TRIpartite motif).
Peng-Cheng, He, Mei, Zhang, Fang, Wang
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The RING domain of human promyelocytic leukemia protein (PML)
Journal of Biomolecular NMR, 2015Shu-Yu, Huang +6 more
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Promyelocytic Leukemia (Pml) Nuclear Bodies Are Protein Structures That Do Not Accumulate RNA
Journal of Cell Biology, 2000François-Michel Boisvert +2 more
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