Results 221 to 230 of about 120,872 (251)

Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human

Blood, 2013
Ya-Ting Chuang, Si-Tse Jiang, Hsiu-Ming Shih   +2 more
exaly   +2 more sources

Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

Nature Medicine, 2014
Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)-retinoic acid receptor-α (PML-RARA) fusion protein, which interferes with nuclear receptor signaling and PML nuclear body (NB) assembly. APL is the only malignancy definitively cured by targeted therapies: retinoic acid (RA) and/or arsenic trioxide, which both trigger PML ...
Julien Ablain, K. Rice, H. Soilihi, A. Reyniès, S. Minucci, H. Thé   +5 more
semanticscholar   +3 more sources

The B-box 1 dimer of human promyelocytic leukemia protein

Journal of Biomolecular NMR, 2014
Shu-Yu Huang, M. Naik, Chi-Fon Chang, Pei-Ju Fang, Ying-Hui Wang, H. Shih, Tai-Huang Huang   +6 more
semanticscholar   +3 more sources

Role of Promyelocytic Leukemia Protein in Host Antiviral Defense

Journal of Interferon & Cytokine Research, 2011
Several pathways have been implicated in the establishment of antiviral state in response to interferon (IFN), one of which implicates the promyelocytic leukemia (PML) protein. The PML gene has been discovered 20 years ago and has led to new insights into oncogenesis, apoptosis, cell senescence, and antiviral defense.
M. Geoffroy, M. Chelbi-alix
semanticscholar   +3 more sources

The promyelocytic leukemia protein stimulates SUMO conjugation in yeast [PDF]

Oncogene, 2006
The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyelocytic leukemia (APL) patients. The promyelocytic leukemia gene product (PML) becomes conjugated in vivo to the small ubiquitin-like protein SUMO-1, altering its behavior and capacity to recruit other ...
T Anan, Mary Dasso
exaly   +3 more sources

The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN).

Biochimica et biophysica acta. Molecular cell research, 2020
The gene encoding promyelocytic leukemia protein (PML) generates several spliced isoforms. Ectopic expression of PML1 promotes the proliferation of ERα-positive MCF-7 breast cancer (BC) cells, while a loss of PML by knockdown or overexpression of PML4 ...
N. Alhazmi, Chun-Peng Pai, Aljawharah Albaqami, Han Wang, Xuan Zhao, Minyue Chen, Po Hu, Shuang Guo, Kyle A. Starost, Omid Hajihassani, M. Miyagi, H. Kao   +11 more
semanticscholar   +1 more source

Acute promyelocytic leukemia with a PLZF-RARα fusion protein

Seminars in Hematology, 2001
In most cases of acute promyelocytic leukemia (APL), a fusion of the promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha) genes occurs, resulting in the expression of a PML-RARalpha chimeric protein. In approximately 1% of the cases of APL, variant chromosomal aberrations may be found fusing RARa with other genes.
Jansen, J.H., Lowenberg, B.
openaire   +4 more sources

Loss of promyelocytic leukemia protein in human gastric cancers

Cancer Letters, 2007
To clarify the clinical implications of promyelocytic leukemia (PML) expression in gastric carcinomas, the expression of PML was analyzed in large series of gastric carcinoma by immunohistochemistry, western blotting and reverse transcription-PCR. PML protein expression was reduced or abolished in gastric carcinomas (31.7 and 10.6%, respectively) by ...
Hee Eun, Lee, Chang Do, Jee, Min A, Kim, Hye Seung, Lee, You Mie, Lee, Byung Lan, Lee, Woo Ho, Kim   +6 more
openaire   +2 more sources

Differential suppressive effect of promyelocytic leukemia protein on the replication of different subtypes/strains of influenza A virus

Biochemical and Biophysical Research Communications, 2009
Gefei Wang, Jun Zeng, Kangsheng Li
exaly   +2 more sources

Isoforms of the promyelocytic leukemia protein differ in their effects on ND10 organization

Experimental Cell Research, 2005
The PML protein is a defining constituent of subnuclear structures known as ND10. PML is expressed as a series of primary sequence isoforms through alternative RNA processing. Expression of each of six distinct PML isoforms that differed in their C-terminal domains caused reproducible differences in the number, size, and shape of ND10 in both ...
Stephanie J, Beech, Katherine J, Lethbridge, Neil, Killick, Nicholas, McGlincy, Keith N, Leppard   +4 more
openaire   +2 more sources