Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [PDF]
Journal for ImmunoTherapy of CancerBackground Despite the successful application of immunotherapy, both innate and acquired resistance are typical in melanoma. Ferroptosis induction appears to be a potential strategy to enhance the effectiveness of immunotherapy. However, the relationship
Hong Liu +13 more
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Bleeding Associated With Antiarrhythmic Drugs in Patients With Atrial Fibrillation Using Direct Oral Anticoagulants: A Nationwide Population Cohort Study [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground This study investigated drug–drug interactions in patients with atrial fibrillation taking both a direct oral anticoagulant (DOAC) and an antiarrhythmic drug.
Victor Chien‐Chia Wu +9 more
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Propafenone Induced Takotsubo Cardiomyopathy: A Mere Coincidence or A New Causal Relationship?
Düzce Tıp Fakültesi Dergisi, 2023 Propafenone is a class 1C antiarrhythmic drug that blocks sodium channels and is used in the treatment of arrhythmia. Because of its rapid effect on terminating paroxysmal episodes of atrial fibrillation, it can be used as a pill-in-the-pocket.
Adem Adar, Fahri Çakan
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The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta [PDF]
Acta Veterinaria, 2013 The information on the inhibitory effect of propafenone in vascular smooth muscle is sparse. Propafenone acts through blockage of voltage-dependent cardiac Na+ channels, L-type Ca2+ channels, voltage-sensitive K+ (Kv) channels, as well as β-adrenergic
Ivković Branka +7 more
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Propafenone-induced liver injury in an elderly patient with paroxysmal atrial fibrillation--a new case report and literature review [PDF]
Acta Poloniae Pharmaceutica, 2023 Antiarrhythmic drugs are used more and more often, which is related to the aging of the population and the growing number of arrhythmias, especially atrial fibrillation (AF).
Katarzyna Giedzicz +5 more
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ANTIARRHYTHMIC EFFICACY OF PROPAFENONE IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION
Рациональная фармакотерапия в кардиологии, 2016 Aim. To assess propafenone antiarrhythmic efficacy and optimal timing of the drug administration for relief of persistent atrial fibrillation (PAF). Material and methods.
R. D. Kurbanov +2 more
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Experience of using propafenone in newborns and young children with arrhythmias
Российский кардиологический журнал, 2020 Aim. To evaluate the efficacy and safety of propafenone therapy in newborns and young children, including children with congenital heart defects (CHD).Material and methods.
T. K. Kruchina +3 more
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Antiarrhythmic effects of newly developed propafenone derivatives [PDF]
Arhiv za farmaciju, 2022 It is well known that the presence of different chemical groups in drug molecules influences their pharmacological properties. The aim of our study is to investigate whether newly synthesized derivatives of propafenone, with changes in benzyl moiety ...
Ivković Branka +4 more
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Clinical and Translational Science, 2022 Propafenone is an antiarrhythmic drug metabolized primarily by cytochrome P450 2D6 (CYP2D6). In adults, propafenone adverse events (AEs) are associated with CYP2D6 poor metabolizer status; however, pediatric data are lacking.
Sudeep D. Sunthankar +5 more
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Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats [PDF]
Veterinarski Glasnik, 2014 By applying of aconitic test in in vivo experiments in rats under deep anesthesia, there was investigated the antiarrhythmic potential of newly synthetized fluorinated derivatives of propafenone.
Ivković Branka +6 more
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