Results 61 to 70 of about 13,230 (236)

Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics

British Journal of Pharmacology, Volume 182, Issue 19, Page 4611-4624, October 2025.
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama, Carlos G. Vanoye, Paul G. DeCaen   +2 more
wiley   +1 more source

Independent derivations of the axis of arrhythmia for predicting drug‐induced torsades de pointes

British Journal of Pharmacology, Volume 182, Issue 18, Page 4299-4313, September 2025.
Abstract Background and Purpose: Torsades de pointes is a potentially lethal ventricular arrhythmia that can be induced by many classes of drugs. The risk for a given drug depends upon the combination of cardiac ion channels that it targets. The axis of arrhythmia quantifies that risk. It is a conceptual line in the electrophysiology that describes the
Stewart Heitmann, Jamie I. Vandenberg, Adam P. Hill   +2 more
wiley   +1 more source

Propafenone Overdose: From Cardiogenic Shock to Brugada Pattern

Arquivos Brasileiros de Cardiologia, 2018
Propafenone is a class IC antiarrhythmic drug used in the treatment of ventricular and supraventricular arrhythmias.1-7 It is primarily a potent sodium channel blocker, yet also exhibits beta-blocking and calcium channel blocking activity.4,6,7 ...
J. Gil, B. Marmelo, L. Abreu, H. Antunes, Luís Ferreira dos Santos, J. Cabral   +5 more
semanticscholar   +1 more source

Long‐Term Follow‐Up of Inducible Bundle Branch Reentrant Ventricular Tachycardia in Patients Without Structural Heart Disease: Beyond the Electrophysiology Laboratory

Journal of Cardiovascular Electrophysiology, Volume 36, Issue 9, Page 2140-2150, September 2025.
ABSTRACT Background Bundle branch reentrant ventricular tachycardia (BBR‐VT) is a rare form of VT occurring in patients with structural heart disease (SHD). Rarely, it can also occur in the absence of SHD. Understanding its clinical and electrophysiologic (EP) properties and outcomes post‐catheter ablation (CA) is crucial. Objective We present a series
Muhieddine Omar Chokr, Haroldo Heitor Ribeiro Filho, Roberto Alvarez Coello, Rodrigo Melo Kulchetscki, Lucas Moura, Francisco Darrieux, Denise T. Hachul, Luciana Sacilotto, Tan C. Wu, Pedro M. Vandoni, Italo B. Souza, Pedro Linhares, Cristiano F. Pisani, Carina A. Hardy, Mauricio I. Scanavacca   +14 more
wiley   +1 more source

Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium [PDF]

, 2000
During atrial fibrillation, ventricular rate is determined by atrioventricular nodal (AVN) conduction, which in part is dependent upon the refractoriness of single AVN cells.
Andrew C. Rankin, Antony J. Workman, Anyukhovsky, Billette, Boyett, Cagin, Carmeliet, Dawodu, Delmar, Delmar, Denes, Duan, Fermini, Ferrier, Gibbs, Giles, Giles, Green, Hancox, Hoshino, Howarth, Isenberg, Jurkiewicz, Kaab, Kathleen A. Kane, Kukushkin, Li, Li, Meijler, Meijler, Mitcheson, Munk, Nakayama, Nattel, Nayebpour, Neher, Nilius, Petrecca, Rankin, Ravens, Shibata, Shigematsu, Tanaka, Vaughan-Williams, Wang, Wang, Wang, Wenckebach, Workman   +48 more
core   +1 more source

Full recovery after prolonged resuscitation from cardiac arrest due to propafenone intoxication

Medicine, 2018
Rationale: The prognosis of cardiac arrest (CA) induced by propafenone intoxication was thought to be very poor. The maximal duration of cardiopulmonary resuscitation (CPR) for propafenone induced CA is unknown.
B. Ling, Ping Geng, D. Tan, J. Walline
semanticscholar   +1 more source

Management of device embolization following left atrial appendage closure: Two cases and a review of the literature

Journal of Arrhythmia, Volume 41, Issue 4, August 2025.
Device embolization following left atrial appendage closure occurs in 0.6%–1.5% of cases and represents a rare but serious complication that can be effectively managed through tailored percutaneous retrieval strategies with high procedural success rates when performed by experienced operators. Abstract Objectives Device embolization (DE) following left
Ahmet Kivrak, Ahmet Hakan Ates, Ugur Canpolat, Mert Dogan, Cem Coteli, Hikmet Yorgun, Mehmet Levent Sahiner, Ergun Barıs Kaya, Kudret Aytemir   +8 more
wiley   +1 more source

Left atrial size after cardioversion for atrial fibrillation: effect of external DC shock [PDF]

, 2003
OBJECTIVE: The aim of this study was to evaluate the effect of external direct current (DC) shock on left atrial (LA) dimension and volumes after cardioversion for atrial fibrillation, and the relation between LA size and atrial function.
L. Bonetti, MATTIOLI, Anna Vittoria, MATTIOLI, Giorgio, S. Bonatti   +3 more
core   +1 more source

Temporary Restoration of Sinus Rhythm Improves Outcomes of Catheter Ablation for Longstanding Persistent Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, Volume 36, Issue 8, Page 1966-1972, August 2025.
Atrial arrhythmia free survival following catheter ablation according to temporary restoration of sinus rhythm attempt. Abbreviation: TRSR, temporary restoration of sinus rhythm. ABSTRACT Background Long‐standing persistent atrial fibrillation (LSPAF) is associated with adverse atrial structural and electrical remodeling, limiting the success of ...
Mohamad Raad, Justice Oranefo, Haran Yogasundaram, Michael I. Gurin, Erica Zado, Michelle Walsh, Timothy Markman, Gustavo Guandalini, Matthew C. Hyman, Robert Schaller, Ramanan Kumareswaran, Gregory Supple, Rajat Deo, Saman Nazarian, Michael Riley, David Lin, Fermin Garcia, David S. Frankel, David Callans, Andrew E. Epstein, Francis E. Marchlinski, Sanjay Dixit   +21 more
wiley   +1 more source

Use of Real‐World Claims Data to Assess the Prevalence of Concomitant Medications to Inform Drug–Drug Interaction Risk in Target Patient Populations

Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 146-155, July 2025.
A common issue in clinical drug development involves drug–drug interactions (DDI) that may lead to altered drug exposure and subsequent altered safety and efficacy of an investigational drug or concomitant medications (conmeds) in the target patient population.
Alice S. Tang, Logan Brooks, Denise M. Boudreau, Pascal Chanu, Amita Joshi, Bianca Vora, Rui Zhu   +6 more
wiley   +1 more source