Results 1 to 10 of about 1,668 (193)

Synthesis and Adrenolytic Activity of New Propanolamines [PDF]

Molecules, 2010
The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described.
Grażyna Groszek, Agata Bajek, Agnieszka Bis, Agnieszka Nowak-Król, Marek Bednarski, Agata Siwek, Barbara Filipek   +6 more
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Synthesis and adrenergic .BETA.-blocking activity of some propanolamine derivatives.

Chemical and Pharmaceutical Bulletin, 1978
Some propanolamine derivatives were synthesized and their β-adrenergic blocking activities were determined. Among the compounds tested, all compounds with benzothiazole nucleus were found to have potent β-adrenergic blocking activity, and those with other nuclei failed to produce substantial β-blocking activity with one exception.
H. OBASE, HIDEKO TATSUNO, Katsutoshi Goto, Koki Shigenobu, Yutaka Kasuya, Y. YAMADA, Kyoichi FUJII, Seiichi Yada   +7 more
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o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as .beta.-blocking/diuretic agents

Journal of Medicinal Chemistry, 1993
A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta 1-adrenoceptor affinity.
Violetta Cecchetti, Arnaldo Fravolini, Fausto Schiaffella, Oriana Tabarrini, Giancarlo Bruni, Giorgio Segre   +5 more
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Enantiomeric Propanolamines as selectiveN-Methyl-d-aspartate 2B Receptor Antagonists [PDF]

Journal of Medicinal Chemistry, 2008
Enantiomeric propanolamines have been identified as a new class of NR2B-selective NMDA receptor antagonists. The most effective agents are biaryl structures, synthesized in six steps with overall yields ranging from 11-64%. The compounds are potent and selective inhibitors of NR2B-containing recombinant NMDA receptors with IC 50 values between 30-100 ...
Yesim A. Tahirovic, Matthew T. Geballe, Ewa Gruszecka‐Kowalik, Scott J. Myers, Polina Lyuboslavsky, Phuong Le, Adam French, Hasan A Irier, Woo‐Baeg Choi, Keith W Easterling, Hongjie Yuan, Lawrence J. Wilson, Robert J. Kotloski, James O McNamara, Raymond Dingledine, Dennis C. Liotta, Stephen F. Traynelis, James P. Snyder   +17 more
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Antibiotic activities of propanolamine containing 1,4-benzoxazin-3-ones against phytopathogenic bacteria

RSC Advances, 2020
Various 1,4-benzoxazin-3-one derivatives containing propanolamine groups have been shown to exhibit good antibacterial activity againstPseudomonas syringaepvactinidiae(Psa),X. axonopodispvcitri(Xac) andXanthomonas oryzaepvoryzae(Xoo).
Jia‐Rui Rao, Liwei Liu, Dan Zeng, Mingwei Wang, Meng Xiang, Yang Song   +5 more
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ANTIMICROBIAL PROPERTIES OF BUTANOLAMINES AND PROPANOLAMINES IN METAL WORKING FLUIDS

The Journal of General and Applied Microbiology, 1979
Seventeen propanolamines, six diisopropanolamines, and two butanolamines were studied for their antimicrobial properties against a mixed flora of fungi and bacteria in cutting fluids. All of the propanolamines showed inhibitory properties in the lubricants.
E. O. Bennett, M.C. Adams, G. Tavana
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.beta.-Adrenergic blocking agents. .alpha.- and .gamma.-Methyl(aryloxy)propanolamines

Journal of Medicinal Chemistry, 1981
A series of gamma-methyl- (5) and alpha-methyl(aryloxy)propanolamines (6) were synthesized and evaluated for beta-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells. Compounds 5a-j and 6a-e were evaluated for beta 1-antagonist action on guinea pig atria and beta 2-antagonist ...
Thomas Lemke, Michael B. Cramer, Stanley W. Adamski, Carolyn A. Pedone, Gary Brooker   +4 more
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New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent .beta.-adrenergic blocking properties

Journal of Medicinal Chemistry, 1985
The synthesis of R-(+) and S-(-) isomers of O-[3-tert-butylamino)-2-hydroxypropyl] cyclopropyl methyl ketone oxime (falintolol) is described. The syn and anti isomers of falintolol were obtained in two different ways from cyclopropyl methyl ketoxime or from falintolol.
Mohamed Bouzoubaa, Gérard Leclerc, Suman Rakhit, G. Andermann   +3 more
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Flavones. 1. Synthesis and antihypertensive activity of (3-phenylflavonoxy)propanolamines without .beta.-adrenoceptor antagonism

Journal of Medicinal Chemistry, 1987
The synthesis of a series of (3-phenylflavonoxy)propanolamines is described. These compounds were evaluated for potential antihypertensive activity in spontaneously hypertensive rats, as well as for in vivo and in vitro evidence of beta-adrenoceptor antagonism. Some of the compounds of this series exhibited effective antihypertensive properties but did
E. S. C. WU, T. E. Cole, T. A. Davidson, James C. Blosser, A R Borrelli, C. R. Kinsolving, T. E. Milgate, Robert B. Parker   +7 more
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SOME PHARMACOLOGICAL PROPERTIES OF 3:3‐DIPHENYL‐PROPANOLAMINES, ‐ALLYLAMINES, AND ‐PROPYLAMINES [PDF]

British Journal of Pharmacology and Chemotherapy, 1951
A. C. White, A. F. GREEN, A.G. Hudson
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