Results 131 to 140 of about 1,962 (207)

beta-Adrenergic blocking agents. alpha- and gamma-methyl(aryloxy)propanolamines.

Journal of Medicinal Chemistry, 1981
A series of gamma-methyl- (5) and alpha-methyl(aryloxy)propanolamines (6) were synthesized and evaluated for beta-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells.
T. L. Lemke, M. Cramer, S. W. Adamski, C. Pedone, G. Brooker   +4 more
semanticscholar   +5 more sources

β-ADRENERGIC BLOCKING AGENTS. α- AND Γ-METHYL(ARYLOXY)PROPANOLAMINES

Chemischer Informationsdienst, 1982
Abstractα‐Naphthol und Phenole (I) reagieren mit dem Epoxid (II) und Aminen zu den Aminoethern (III) und (IV), die durch Säulenchromatographie an Kieselgel voneinander getrennt werden können.
T. L. Lemke, M. Cramer, S. W. Adamski, C. Pedone, G. Brooker   +4 more
semanticscholar   +4 more sources

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o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents.

Journal of Medicinal Chemistry, 1993
A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta 1-adrenoceptor ...
V. Cecchetti, A. Fravolini, F. Schiaffella, O. Tabarrini, G. Bruni, G. Segre   +5 more
semanticscholar   +5 more sources

Enzyme‐Catalyzed Stereoselective Synthesis of (S)‐Propanolamines.

ChemInform, 2010
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Kamal, M. V. Rao
semanticscholar   +4 more sources

Substituted alpha-dialkylaminoalkyl-l-naphthalenemethanols; synthesis of some propanolamines by means of Grignard reagents.

The Journal of Organic Chemistry, 1946
Thomas L. Jacobs, S. Winstein, Gustave B. Linden, D. E. Seymour   +3 more
semanticscholar   +5 more sources

[(Arylcarbonyl)oxy]propanolamines. 1. Novel beta-blockers with ultrashort duration of action.

Journal of Medicinal Chemistry, 1984
Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration.
S. Kam, W. Matier, K. X. Mai, C. Barcelon-Yang, R. J. Borgman, J. O'Donnell, H. Stampfli, C. Y. Sum, W. G. Anderson, R. Gorczynski   +9 more
semanticscholar   +4 more sources

Role of the (acyloxy)methyl moiety in eliciting the adrenergic beta-blocking activity of 3-(acyloxy)propanolamines.

Journal of Medicinal Chemistry, 1987
Some totally aliphatic 3-(acyloxy)propanolamines were synthesized with the aim of testing whether beta-blocking activity could be obtained from this class of drugs, even in the absence of an aromatic group. The significant and, in most cases, competitive
B. Macchia, A. Balsamo, A. Lapucci, F. Macchia, A. Martinelli, H. Ammon, S. M. Prasad, M. Breschi, M. Ducci, E. Martinotti   +9 more
semanticscholar   +4 more sources

Substituted propanolamines and alkylamines derived from fluoxetine as potent appetite suppressants.

Bioorganic & Medicinal Chemistry, 2005
A series of propanolamine and alkylamine analogues of fluoxetine (7-26, 28-31) were synthesized and assessed for their anorexigenic and antidepressant activities. Effect of various substituents at C-4 aryl position of fluoxetine has also been studied.
K. Bhandari, S. Srivastava, Girija Shanker, C. Nath   +3 more
semanticscholar   +4 more sources

Flavones. 1. Synthesis and antihypertensive activity of (3-phenylflavonoxy)propanolamines without beta-adrenoceptor antagonism.

Journal of Medicinal Chemistry, 1987
The synthesis of a series of (3-phenylflavonoxy)propanolamines is described. These compounds were evaluated for potential antihypertensive activity in spontaneously hypertensive rats, as well as for in vivo and in vitro evidence of beta-adrenoceptor ...
E. Wu, T. E. Cole, T. A. Davidson, J. Blosser, A. Borrelli, C. R. Kinsolving, T. E. Milgate, R. Parker   +7 more
semanticscholar   +4 more sources

Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.

Journal of Medicinal Chemistry, 1990
Several (aryloxy)propanolamines and related compounds (i.e. 5-13, 16-18, 20-24, 27-33, 35, 37-39, 41, and 42) were synthesized and investigated for their class III electrophysiological activity and class II (beta-blocking) effects with use of in vitro ...
R. Lis, T. K. Morgan, A. J. Marisca, R. Gomez, J. Lind, D. Davey, G. Phillips, M. Sullivan   +7 more
semanticscholar   +2 more sources