Results 131 to 140 of about 1,984 (207)

o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as .beta.-blocking/diuretic agents

Journal of Medicinal Chemistry, 1993
A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta 1-adrenoceptor affinity.
CECCHETTI, Violetta, FRAVOLINI, Arnaldo, SCHIAFFELLA, Fausto, TABARRINI, Oriana, Giancarlo Bruni, Giorgio Segre   +5 more
openaire   +5 more sources

SUBSTITUTED α-DIALKYLAMINOALKYL-1-NAPHTHALENE-METHANOLS. VII. SYNTHESIS OF SOME PROPANOLAMINES BY MEANS OF GRIGNARD REAGENTS¹

The Journal of Organic Chemistry, 1946
Thomas L. Jacobs, S. Winstein, Gustave B. Linden, D. E. Seymour   +3 more
semanticscholar   +5 more sources

Persistence and Biodegradation of Monoethanolamine and 2-Propanolamine at an Abandoned Industrial Site

Environmental Science & Technology, 2005
Soil and groundwater samples were collected at the site of a former chemical processing plant in areas impacted by accidental releases of MEA (monoethanolamine) and IPA (2-propanolamine or isopropanolamine). Although their use had ceased ca. 10 years before sample collection, soils collected at contamination sites had MEA concentrations ranging from ca.
Steven B. Hawthorne, Alena Kubátová, J.R. Gallagher, James A. Sorensen, David J. Miller   +4 more
openalex   +4 more sources

Substituted propanolamines and alkylamines derived from fluoxetine as potent appetite suppressants☆

Bioorganic & Medicinal Chemistry, 2005
A series of propanolamine and alkylamine analogues of fluoxetine (7-26, 28-31) were synthesized and assessed for their anorexigenic and antidepressant activities. Effect of various substituents at C-4 aryl position of fluoxetine has also been studied.
Chandishwar Nath, Shipra Srivastava, Girija Shanker, Kalpana Bhandari   +3 more
openaire   +4 more sources

[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action

Journal of Medicinal Chemistry, 1984
Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration. The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.
S T, Kam, W L, Matier, K X, Mai, C, Barcelon-Yang, R J, Borgman, J P, O'Donnell, H F, Stampfli, C Y, Sum, W G, Anderson, R J, Gorczynski   +9 more
openaire   +4 more sources

Flavones. 1. Synthesis and antihypertensive activity of (3-phenylflavonoxy)propanolamines without .beta.-adrenoceptor antagonism

Journal of Medicinal Chemistry, 1987
The synthesis of a series of (3-phenylflavonoxy)propanolamines is described. These compounds were evaluated for potential antihypertensive activity in spontaneously hypertensive rats, as well as for in vivo and in vitro evidence of beta-adrenoceptor antagonism. Some of the compounds of this series exhibited effective antihypertensive properties but did
James C. Blosser, A. R. Borrelli, R. B. Parker, C. R. Kinsolving, E. S. C. Wu, T. E. Cole, T. E. Milgate, T. A. Davidson   +7 more
openaire   +4 more sources

Role of the (acyloxy)methyl moiety in eliciting the adrenergic .beta.-blocking activity of 3-(acyloxy)propanolamines

Journal of Medicinal Chemistry, 1987
Some totally aliphatic 3-(acyloxy)propanolamines were synthesized with the aim of testing whether beta-blocking activity could be obtained from this class of drugs, even in the absence of an aromatic group. The significant and, in most cases, competitive beta-blocking activity shown by the compounds under examination, together with the results of a ...
MACCHIA B, BALSAMO A, LAPUCCI, ANNALINA, MACCHIA F, MARTINELLI, ADRIANO, AMMON H. L, PRASAD S. M, BRESCHI, MARIA CRISTINA, DUCCI, MICHELE, MARTINOTTI E.   +9 more
openaire   +4 more sources

b-Adrenergic blocking agents. Nitrogen heteroaryl-substituted 2-propanolamines and ethanolamines

Journal of Medicinal Chemistry, 1973
AbstractEine Reihe von Methylheterocyclen (I) wird in Form ihrer Lithiumderivate (II) mit den Aminoacetonitrilen (III) zu den Enaminen (IV) umgesetzt, die durch Hydrolyse, Reduktion mit Natriumborhydrid und hydrierende Debenzylierung in Propanolamine (VII) umgewandelt werden.
Robert F. Meyer, Ruth M. Corey, Charlotte D. Stratton, Stephen G. Hastings   +3 more
openaire   +5 more sources

o-Allyloxy-phenoxy-propanolamine, eine neue Gruppe adrenergischer β-Rezeptoren-Blocker

Experientia, 1967
The synthesis of a new class of adrenergicβ-receptor blocking agents based upon ao-allyloxy-phenoxy-propanolamine structure is described. The structure activity relationships were studied, and the structural elements responsible for an optimal pharmacological effect are discussed.
M. Wilhelm, P. R. Hedwall, Max Meier
openalex   +4 more sources

ChemInform Abstract: SYNTHESIS AND ADRENERGIC β-BLOCKING ACTIVITY OF SOME PROPANOLAMINE DERIVATIVES

Chemischer Informationsdienst, 1978
AbstractEs werden einige Propanolamin‐Derivate wie z.B. (I) und (II) dargestellt, von denen erstere bessere β‐Blocker als Sotalol sind.
H. OBASE, HIDEKO TATSUNO, Katsutoshi Goto, Koki Shigenobu, Yoshitoshi Kasuya, Y. YAMADA, Kyoichi FUJII, Seiichi Yada   +7 more
openalex   +3 more sources