Results 141 to 150 of about 1,668 (193)

Synthesis and beta-adrenergic antagonist activity of heterocyclic propanolamines.

Drug design and discovery, 1993
The synthesis and beta-adrenergic antagonist activities of a group of 1-(heteroaryloxy)- and 1-(heteroaryl)-3-alkylamino-2-propanols is described. beta 1-Adrenolytic (atria) structure-activity correlations indicated that replacement of the 1-naphthyl moiety of propranolol by a 4-quinolyl- (10), 2-quinolyl- (24), or 2-pyrimidyl- (26) heterocyclic moiety
Vo D, Wolowyk Mw, Knaus Ee
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Synthesis and study of the antiviral activity of propanolamine derivatives

Pharmaceutical Chemistry Journal, 1987
L. M. M. Stankyavichene, A. P. Stankyavichyus, M. S. Sapragonene, S. P. Riselis, П. Б. Терентьев, Kh. S. Azhami, G. V. Vladyko, L. V. Korobchenko, E. I. Boreko   +8 more
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Choline cannot be replaced by propanolamine in mice

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007
Choline is an important nutrient for humans and animals. Animals obtain choline from the diet and from the catabolism of phosphatidylcholine made by phosphatidylethanolamine N-methyltransferase (PEMT). The unique model of complete choline deprivation is Pemt(-/-) mice that are fed a choline-deficient diet.
Zhaoyu, Li, Dennis E, Vance
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Enzyme catalyzed stereoselective synthesis of (S)-propanolamines

Tetrahedron: Asymmetry, 1994
Abstract Stereoselective synthesis of (S)-propanolamines has been carried out by the ring opening of racemic epoxides with 2-propylamine in presence of lipases and subtilisin. The effect of solvent towards selectivity has also been studied.
Ahmed Kamal, Maddamsetty V Rao
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THE REACTION OF PHOSPHORUS TRICHLORIDE WITH PROPANOLAMINE-1.3

Phosphorus, Sulfur, and Silicon and the Related Elements, 1994
Abstract The reaction of PCl3 with propanolamine-1.3 in the presence of Net3 was studied and found to form two heterocyclic compounds, the 2-chloro-3-dichlorophosphanyl-1.3.2-oxazaphosphorinane and the 2-aminopropoxy-1.3.2-oxazaphosphorinane, which could be isolated and characterized.
Cornelia Mundt, Lothar Riesel
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3-(Acyloxy)propanolamines: agents with β-adrenergic blocking activity

European Journal of Medicinal Chemistry, 1994
Abstract A series of totally aliphatic 3-(acyloxy)propanolamine derivatives were prepared and their pA2-values were determined employing the guinea-pig atrium. Compounds with an acetyl or methyl succinoyl half ester moiety showed a pronounced β1-adrenergic blocking activity.
J Leuschner, H Schäfer, F Leuschner
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ChemInform Abstract: Enzyme‐Catalyzed Stereoselective Synthesis of (S)‐Propanolamines.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. KAMAL, M. V. RAO
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b-Adrenergic blocking agents. Nitrogen heteroaryl-substituted 2-propanolamines and ethanolamines

Journal of Medicinal Chemistry, 1973
Eine Reihe von Methylheterocyclen (I) wird in Form ihrer Lithiumderivate (II) mit den Aminoacetonitrilen (III) zu den Enaminen (IV) umgesetzt, die durch Hydrolyse, Reduktion mit Natriumborhydrid und hydrierende Debenzylierung in Propanolamine (VII) umgewandelt werden.
R F, Meyer, C D, Stratton, S G, Hastings, R M, Corey   +3 more
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Substituted propanolamines and alkylamines derived from fluoxetine as potent appetite suppressants

Bioorganic & Medicinal Chemistry, 2005
A series of propanolamine and alkylamine analogues of fluoxetine (7-26, 28-31) were synthesized and assessed for their anorexigenic and antidepressant activities. Effect of various substituents at C-4 aryl position of fluoxetine has also been studied.
Kalpana, Bhandari, Shipra, Srivastava, Girija, Shanker, Chandishwar, Nath   +3 more
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Synthesis and beta-adrenergic activity of new completely aliphatic 3-(methyleneaminoxy)propanolamine derivatives.

, 1994
In a previous paper, it had been found that completely aliphatic 3-(methylene aminoxy)propanolamine derivatives showed a good beta-blocking adrenergic activity directed prevalently towards beta(2)-tracheal receptors. In an attempt to change the beta-adrenergic properties of these compounds from antagonist to agonist, while still retaining the beta(2 ...
Antonio Balsamo, Daniela Gentili, Annalina Lapucci, Marco Macchia, Adriano Martinelli, Elisabetta Orlandini, G. Ferni, Mario Pinza   +7 more
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