Results 151 to 160 of about 1,668 (193)

Vanillylamide-Based Propanolamine Derivative Displays α/β-Adrenoceptor Blocking and Vasodilating Properties

Journal of Cardiovascular Pharmacology, 2002
A propanolamine derivative with vanillylamide base, KMUP 880602, was first investigated under in vivo and in vitro conditions. IV KMUP 880602 (0.1, 0.5, 1.0, and 2.0 mg/kg) produced dose-dependent hypotensive and bradycardia responses in pentobarbital-anesthetized Wistar rats. KMUP 880602 also markedly inhibited both the tachycardia effects induced by (
Jwu-Lai, Yeh, Jiunn-Ren, Wu, Chaw-Chi, Chiu, Yea-Wen, Chen, Yi-Ching, Lo, Young-Tso, Lin, Chang-Jenq, Cheng, Ing-Jun, Chen   +7 more
openaire   +2 more sources

Synthesis and beta-adrenergic antagonist activity of novel (3-cyanodihydropyridyl)propanolamines.

Drug design and discovery, 1992
The synthesis and beta-adrenergic antagonist activities of 1-(1-dihydropyridyl)-3-alkylamino-2-propanols (9-16) in which the aryloxy group of aryloxypropanolamines (1) is replaced by a 1-[2-t-(n-)butyl-3-cyano-1,2-dihydropyridyl] (9-12) or 1-[6-t-(n-)butyl-3-cyano-1,6-dihydropyridyl] (13-16) moiety is described.
D, Vo, M W, Wolowyk, E E, Knaus
openaire   +2 more sources

[p-(Thienylcarboxamido)phenoxy]propanolamine derivatives as diuretic and .beta.-adrenergic receptor blocking agents

Journal of Medicinal Chemistry, 1986
The synthesis of [[(thienylcarbonyl)amino]phenoxy]propanolamines and their beta-adrenergic blocking and diuretic activity are described. Structure-activity relationships demonstrated that ortho substitution of the phenoxy ring with an hydrogen or an ester function leads to compounds possessing both activities.
E, Bouley, J M, Teulon, M, Cazes, A, Cloarec, R, Deghenghi   +4 more
openaire   +2 more sources

[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action

Journal of Medicinal Chemistry, 1984
Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration. The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.
S T, Kam, W L, Matier, K X, Mai, C, Barcelon-Yang, R J, Borgman, J P, O'Donnell, H F, Stampfli, C Y, Sum, W G, Anderson, R J, Gorczynski   +9 more
openaire   +2 more sources

Synthesis and Properties of Cu(Benzoylacetone-ethanolamine) and Cu(Benzoylacetone-propanolamine)

Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1991
Abstract The Schiff base resulting from benzoylacetone and ethanolamine or propanolamine has been used to form copper(II) complexes. Cu(benzoylacetone-ethanolamine) is tetrameric with a ferromagnetic ground state. Cu(benzoylacetone-propanolamine) is dimeric with overall antiferromagnetic interaction and a singlet ground state.
K. Hines, L. J. Theriot
openaire   +1 more source

Persistence and Biodegradation of Monoethanolamine and 2-Propanolamine at an Abandoned Industrial Site

Environmental Science & Technology, 2005
Soil and groundwater samples were collected at the site of a former chemical processing plant in areas impacted by accidental releases of MEA (monoethanolamine) and IPA (2-propanolamine or isopropanolamine). Although their use had ceased ca. 10 years before sample collection, soils collected at contamination sites had MEA concentrations ranging from ca.
Steven B, Hawthorne, Alena, Kubátová, John R, Gallagher, James A, Sorensen, David J, Miller   +4 more
openaire   +2 more sources

ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL STUDY OF 3‐PHENYL‐2‐PROPANOLAMINES

Chemischer Informationsdienst, 1979
AbstractAus Benzylchlormethyl‐keton (I) und den Grignard‐Reagenzien (II) werden die entsprechenden Chloralkohole (IIIa)‐(IIId) dargestellt und mit den sek. Aminen (IV) zu den entsprechenden Aminoalkoholen (Va)‐(Vd) umgesetzt.
H. GALONS, J.‐F. GIRARDEAU, C. COMBET FARNOUX, M. MIOCQUE, C. DUPONT, J. WEPIERRE   +5 more
openaire   +1 more source

Phencyclidine-like behavioral effects of 2-methyl-3,3-diphenyl-3-propanolamine (2-MDP)

Pharmacology Biochemistry and Behavior, 1984
2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) produced effects in animals similar to those produced by the dissociative anesthetics such as phencyclidine (PCP). Specifically, it shared the discriminative stimulus properties of PCP in rats trained to discriminate PCP (1 mg/kg) from saline; at higher doses, it disrupted brightness discrimination and ...
A H, Tang, A A, Cangelosi, R A, Code, S R, Franklin   +3 more
openaire   +2 more sources

Synthesis of a novel series of (aryloxy)propanolamines: new selective .beta.2-blocking agents

Journal of Medicinal Chemistry, 1984
A new family of beta-blocking drugs is described. The originality of the new molecules lies in their functionalized hydrophobic folded structure, the basic part of which contains a benzocyclobutene ring. Excellent beta 2-blocker selectivity has been obtained with some of these compounds.
M C, Carre, A, Youlassani, P, Caubere, A, Saint-Aubin-Floch, M, Blanc, C, Advenier   +5 more
openaire   +2 more sources

ChemInform Abstract: Synthesis of Propanolamine Derivatives and Study of Their Antiviral Activity.

ChemInform, 1987
AbstractThe propanolamine derivatives (III), (VI), and (IX) are prepared from the epoxides (I) or the amines (IV) and (VII) as shown in the reaction scheme.
L. M. M. STANKYAVICHENE, A. P. STANKYAVICHYUS, M. S. SAPRAGONENE, S. P. RISELIS, P. B. TERENT'EV, KH. S. AZHAMI, G. V. VLADYKO, L. V. KOROBCHENKO, E. I. BOREKO   +8 more
openaire   +1 more source