Results 31 to 40 of about 1,956 (206)

Formulation, Characterization, and In Vitro Evaluation of Transdermal Patches for Inhibiting Crystallization of Mefenamic Acid

Journal of Drug Delivery, Volume 2017, Issue 1, 2017., 2017
The crystallization of mefenamic acid in transdermal patch is a major problem that makes the patch unstable and decreases the drug release. The additive was used to inhibit crystallization of a mefenamic acid. Among the different types of additives, polyvinylpyrrolidone (PVP) K30 and PVP K90 were studied and found to be highly effective in inhibiting ...
Jirapornchai Suksaeree, Patsakorn Siripornpinyo, Somruethai Chaiprasit, Steven H. Neau   +3 more
wiley   +1 more source

Synthesis and biological evaluation of thiazolidinedione derivatives of chalcones and flavones as antihyperglycemic and antidyslipidemic agents  [PDF]

, 2021
A series of chalcone and flavone derivatives (6a-d, 9a-f) based on 2,4-thiazolidinedione have been synthesized and evaluated for in vivo antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models and also ...
Pratap, Ram , Satyanarayana, Mavurapu , Shukla, Poonam , Srivastava, Arvind K, Tiwari, Priti , Tripathi, Brajendra K   +5 more
core   +4 more sources

Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity. [PDF]

, 2018
Ketamine, a channel blocking NMDA receptor antagonist, is used off-label for its psychedelic effects, which may arise from a combination of several inter-related actions.
Bortolotto, ZA, Collingridge, GL, Ingram, R, Jane, DE, Kang, H, Lightman, S, Lodge, D, Volianskis, A   +7 more
core   +3 more sources

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P‐Glycoprotein (P‐gp) and Breast Cancer Resistance Protein (BCRP)

ChemMedChem, Volume 11, Issue 12, Page 1380-1394, June 20, 2016., 2016
P‐gp versus BCRP: This study comprises a combined approach of synthesis, in silico prediction, and in vitro testing to identify molecular features triggering transporter selectivity. Synthesis and testing of a series of 15 propafenone analogues with varied rigidity and basicity of substituents provide first trends for selective and dual inhibitors ...
Theresa Schwarz, Floriane Montanari, Anna Cseke, Katrin Wlcek, Lene Visvader, Sarah Palme, Peter Chiba, Karl Kuchler, Ernst Urban, Gerhard F. Ecker   +9 more
wiley   +1 more source

Optical control of the ?2-adrenergic receptor with opto-prop-2: A cis-active azobenzene analog of propranolol [PDF]

, 2022
In this study, we synthesized and evaluated new photoswitchable ligands for the beta-adrenergic receptors ?1-AR and ?2-AR, applying an azologization strategy to the first-generation beta-blocker propranolol.
Arimont, Marta, Bosma, Reggie, Custers, Hans, Dijon, Nicola C., Hauwert, Niels J., Holliday, Nicholas D., Kuster, Diederik W.D., Leurs, Rob, Riemens, Rick, Schihada, Hannes, Shi, Shuang, van de Stolpe, Andrea, Vischer, Henry F., Wijtmans, Maikel, Zheng, Yang   +14 more
core   +2 more sources

The Influence of Molecular Structure Modifications on Vibrational Properties of Some Beta Blockers: A Combined Raman and DFT Study

Journal of Spectroscopy, Volume 2016, Issue 1, 2016., 2016
We report results of a systematic Raman, SERS, and DFT study on four beta blocking molecules: Atenolol, Metoprolol, Propranolol, and, for the first time reported in the literature, Bisoprolol. The choice of these molecules was motivated by the structural similarities between Atenolol, Bisoprolol, and Metoprolol on one hand and by their differences ...
A. Farcaș, C. Iacoviță, E. Vințeler, V. Chiș, R. Știufiuc, C. M. Lucaciu, Stephen Cooke   +6 more
wiley   +1 more source

Different Strategies of Asymmetric Synthesis [PDF]

Asymmetric synthesis is one of the significant subjects of research in recent times. It incorporates regulating stereochemistry of compounds to produce enantiomerically pure chemical substances. Chiral auxiliaries/substrates and enantioselective reagents
Hemant Khambete, Khushboo Arora, Ritu Sapra, Sanjay Jain, Sumeet Prachand   +4 more
core   +3 more sources

Enantioselective Synthesis of Antiepileptic Drug: (-)-Levetiracetam—Synthetic Applications of the Versatile New Chiral N [PDF]

, 2013
We report an asymmetric synthesis of (-)-Levetiracetam (1) in six steps starting from versatile new chiral N-sulfinimine (3). The key step, stereoselective 1,2-addition of ethylmagnesium bromide (EtMgBr) to chiral N-sulfinimine derived from (R ...
E. Naresh, G. Madhusudhan, K. Chandra Babu, K. Mukkanti, K. Ram Mohan, R. Buchi Reddy   +5 more
core   +1 more source

Microfluidic approaches for the fabrication of gradient crosslinked networks based on poly(ethylene glycol) and hyperbranched polymers for manipulation of cell interactions

Journal of Biomedical Materials Research Part A, Volume 96A, Issue 1, Page 196-203, January 2011., 2011
Abstract High‐throughput methods allow rapid examination of parameter space to characterize materials and develop new polymeric formulations for biomaterials applications. One limitation is the difficulty of preparing libraries and performing high‐throughput screening with conventional instrumentation and sample preparation.
S. Pedron, C. Peinado, P. Bosch, J. A. Benton, K. S. Anseth   +4 more
wiley   +1 more source

Characterization of a solvent for chemical absorption-based CO2 capture [PDF]

, 2021
The diploma thesis is focused on the thermodynamic characterization of an aqueous 3-amino-1-propanol (AP) solution, which is used as a promising solvent for post-combustion CO2 capture from exhaust gases.
Bunevska, Tanja
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