Results 31 to 40 of about 1,984 (207)

Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects [PDF]

, 2015
SummaryStroke remains a significant problem despite decades of work on neuroprotective strategies. NMDA receptor (NMDAR) antagonists are neuroprotective in preclinical models, but have been clinically unsuccessful, in part due to side effects.
Ganesh, Thota, Liotta, Dennis C., Lyuboslavsky, Polina, Menaldino, David S., Myers, Scott J., Nicholson, Katherine L., Snyder, James P., Swanger, Sharon A., Tahirovic, Yesim A., Traynelis, Stephen F., Wells, Gordon, Wilson, Lawrence J., Yuan, Hongjie   +12 more
core   +1 more source

The Influence of Molecular Structure Modifications on Vibrational Properties of Some Beta Blockers: A Combined Raman and DFT Study

Journal of Spectroscopy, Volume 2016, Issue 1, 2016., 2016
We report results of a systematic Raman, SERS, and DFT study on four beta blocking molecules: Atenolol, Metoprolol, Propranolol, and, for the first time reported in the literature, Bisoprolol. The choice of these molecules was motivated by the structural similarities between Atenolol, Bisoprolol, and Metoprolol on one hand and by their differences ...
A. Farcaș, C. Iacoviță, E. Vințeler, V. Chiș, R. Știufiuc, C. M. Lucaciu, Stephen Cooke   +6 more
wiley   +1 more source

Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols [PDF]

, 2010
In this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species
Adilson David Da Silva, Elaine Soares Coimbra, Liliane Sena Pinheiro, Mireille Le Hyaric, Roberta Novaes Reis Corrales   +4 more
core   +2 more sources

Experience (Mostly Negative) with the Use of Sympathomimetic Agents for Weight Loss

Journal of Obesity, Volume 2011, Issue 1, 2011., 2011
Sympathomimetic agents have a poor history of long‐term success in the treatment of obesity. From earlier experiences with amphetamine and its analogs, to more recent drugs with direct effects on adrenergic receptors or indirect effects from release of catecholamines or inhibition of reuptake, cardiovascular toxicity (strokes and cardiac arrhythmias ...
Mario A. Inchiosa Jr., A. Halpern
wiley   +1 more source

Reductive Amination of 1-Hydroxy-2-propanone Over Nickel and Copper Catalysts [PDF]

, 2017
The one-step reductive amination of 1-hydroxy-2-propanone (acetol) with ammonia to 2-aminopropanol (2-APOL) over commercial nickel and copper catalysts has been studied in the continuous fixed-bed reactor at the temperature from 130 to 220 °C and ...
J. Trejbal, M. Zapletal, N. Ruhswurmová, T. Trégner   +3 more
core   +3 more sources

Clean Energy Technology Observatory: Carbon Capture Utilisation and Storage in the European Union – 2022 Status Report on Technology Development, Trends, Value Chains and Markets [PDF]

, 2022
This report is an output of the Clean Energy Technology Observatory (CETO). CETO’s objective is to provide an evidence-based analysis feeding the policy making process and hence increasing the effectiveness of R&I policies for clean energy technologies ...
EULAERTS Olivier, GEORGAKAKI Aliki, GONZALEZ SANCHEZ Maria Del Rocio, GRABOWSKA Marcelina, INCE Ela, JOANNY ORDONEZ Geraldine, KAPETAKI Zoi, KUOKKANEN Anna, LETOUT Simon, MOUNTRAKI Aikaterini, SHTJEFNI Drilona   +10 more
core   +1 more source

Different Strategies of Asymmetric Synthesis [PDF]

Asymmetric synthesis is one of the significant subjects of research in recent times. It incorporates regulating stereochemistry of compounds to produce enantiomerically pure chemical substances. Chiral auxiliaries/substrates and enantioselective reagents
Hemant Khambete, Khushboo Arora, Ritu Sapra, Sanjay Jain, Sumeet Prachand   +4 more
core   +3 more sources

Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity. [PDF]

, 2018
Ketamine, a channel blocking NMDA receptor antagonist, is used off-label for its psychedelic effects, which may arise from a combination of several inter-related actions.
Bortolotto, ZA, Collingridge, GL, Ingram, R, Jane, DE, Kang, H, Lightman, S, Lodge, D, Volianskis, A   +7 more
core   +3 more sources

Nickel‐Catalyzed O‐Arylation of N‐Protected Amino Alcohols with (Hetero)aryl Chlorides

Chemistry – A European Journal, Volume 31, Issue 10, February 17, 2025.
The first effective base metal‐catalyzed protocol for C−O cross‐coupling of primary, secondary, and tertiary alcohol‐containing N‐Boc protected amino alcohols with (hetero)aryl chlorides, affording access to new and useful N‐protected aryloxyamine compounds, is reported.
Kathleen M. Morrison, Emily C. Jackson, Erika M. H. Elliott, Mark Stradiotto   +3 more
wiley   +1 more source

Straightforward Synthesis of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols – Accessing Fluorinated Derivatives of Commercialized Beta‐Blockers

European Journal of Organic Chemistry, Volume 27, Issue 35, September 16, 2024.
An array of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols were synthesized using iodohydroxylation of gem‐difluorinated allyl aryl ethers followed by epoxidation and ring‐opening with an amine in a one‐pot/two‐step fashion. This approach allows the synthesis of a set of gem‐difluorinated derivatives of commercialized beta‐blockers.
Jan‐Ole Moritz, Shuang Liu, Katharina Konieczny, Dirk Michalik, Udo Kragl, Helfried Neumann, Matthias Beller   +6 more
wiley   +1 more source