Results 61 to 70 of about 129,849 (273)

The first partnership experience and personality development. A propensity score matching study in young adulthood [PDF]

, 2015
Personality development in young adulthood has been associated with the experience of a number of new social roles. However, the causal interpretation of these findings is complicated by the fact that it is not possible to randomize young adults by their
Becker, Michael, Lüdtke, Oliver, Trautwein, Ulrich, Wagner, Jenny   +3 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Estimating Causal Effect of Two-Dose COVID-19 Vaccination on Hospitalization

Journal of Biostatistics and Epidemiology
Objective: To estimate the effectiveness of two-dose COVID-19 vaccination in reducing hospitalization, accounting for complex confounding factors in observational studies.
Mohammad Taghi Shakeri, Mahboobeh Taherizadeh, Saeed Akhlaghi, Ehsan Mosa Farkhani   +3 more
doaj   +1 more source

Survival after Abdominoperineal and Sphincter-Preserving Resection in Nonmetastatic Rectal Cancer: A Population-Based Time-Trend and Propensity Score-Matched SEER Analysis

Gastroenterology Research and Practice, 2017
Background. Abdominoperineal resection (APR) has been associated with impaired survival in nonmetastatic rectal cancer patients. It is unclear whether this adverse outcome is due to the surgical procedure itself or is a consequence of tumor-related ...
Rene Warschkow, Sabrina M. Ebinger, Walter Brunner, Bruno M. Schmied, Lukas Marti   +4 more
doaj   +1 more source

Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance

BMC Medical Research Methodology, 2017
Background Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment.
Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais, Yannick Le Manach   +6 more
doaj   +1 more source

Merits and caveats of propensity scores to adjust for confounding

Nephrology Dialysis Transplantation, 2018
AbstractProper adjustment for confounding is essential when estimating the effects of treatments or risk factors on health outcomes in observational data. To this end, various statistical methods have been developed. In the past couple of years, the use of propensity scores (PSs) to control for confounding has increased.
Fu, E.L., Groenwold, R.H.H., Zoccali, C., Jager, K.J., Diepen, M. van, Dekker, F.W.   +5 more
openaire   +4 more sources

An overview of the objectives of and the approaches to propensity score analyses [PDF]

, 2017
The assessment of treatment effects from observational studies may be biased with patients not randomly allocated to the experimental or control group. One way to overcome this conceptual shortcoming in the design of such studies is the use of propensity
Heinze, Georg, Jüni, Peter
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Assessment of the E-value in the presence of bias amplification: a simulation study

BMC Medical Research Methodology
Background The E-value, a measure that has received recent attention in the comparative effectiveness literature, reports the minimum strength of association between an unmeasured confounder and the treatment and outcome that would explain away the ...
Eric Barrette, Lucas Higuera, Kael Wherry   +2 more
doaj   +1 more source

Developing and Applying the Propensity Score to Make Causal Inferences: Variable Selection and Stratification

Frontiers in Psychology, 2017
This Monte Carlo simulation examined the effects of variable selection (combinations of confounders with four patterns of relationships to outcome and assignment to treatment) and number of strata (5, 10, or 20) in propensity score analyses.
Jill L. Adelson, D. B. McCoach, H. J. Rogers, Jonathan A. Adelson, Timothy M. Sauer   +4 more
doaj   +1 more source