Results 121 to 130 of about 8,235 (150)
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Molecular Immunology, 1982
Abstract Physical measurements on native properdin suggest that this protein is a trimer of mol. wt 145,600–152,600 consisting of three apparently identical subunits of mol. wt 49, 100 each.
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Abstract Physical measurements on native properdin suggest that this protein is a trimer of mol. wt 145,600–152,600 consisting of three apparently identical subunits of mol. wt 49, 100 each.
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Immunochemistry, 1976
Abstract When activated properdin convertase ( PC ) is added to normal human serum, properdin is altered as manifested by a shift in electrophoretic mobility and a decrease in the amount of protein measurable by radial immunodiffusion. The degree of alteration is dependent on the concentration of PC and the time of incubation. Thus, PC
Joan R Urmson +2 more
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Abstract When activated properdin convertase ( PC ) is added to normal human serum, properdin is altered as manifested by a shift in electrophoretic mobility and a decrease in the amount of protein measurable by radial immunodiffusion. The degree of alteration is dependent on the concentration of PC and the time of incubation. Thus, PC
Joan R Urmson +2 more
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Immunity, Infection, and Properdin
Archives of Internal Medicine, 1959The word "immune" derives from the Romans, who used it to describe those persons declared exempt from taxation and other obligations to the state. The meaning was later applied to the exemption and protection due to the early Christian church and its officers, as in "papal immunity" or the "immunity from arrest" found in the sanctuary of the church ...
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Vox Sanguinis, 1956
RésuméLe système bactéricide de la properdine comprend 6 facteurs: la properdine ‐ les 4 constituants du complement et des ions de magnésium. La properdine humaine est une euglobuline de poids moléculaire très élevé et ne représente pas plus de 0.03 pour cent des protéines sériques totales.
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RésuméLe système bactéricide de la properdine comprend 6 facteurs: la properdine ‐ les 4 constituants du complement et des ions de magnésium. La properdine humaine est une euglobuline de poids moléculaire très élevé et ne représente pas plus de 0.03 pour cent des protéines sériques totales.
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Preparation of properdin by affinity chromatography
Immunochemistry, 1977Abstract A new technique is described for the preparation of properdin by immune affinity chromatography. Anti-human properdin antibody was attached via its carboxyl groups to amine-substituted Sepharose 4B with the use of a water soluble carbodiimide.
James D. Ogle +2 more
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The Properdin System and Immunity
The Journal of Immunology, 1959Summary A 100-fold purification of the third component of human complement (C′3) has been achieved, employing Fraction III-1 (Cohn Method 9) as starting material. The final product was electrophoretically heterogeneous but was free of the activities of other components of complement, properdin, plasmin and C′1-esterase.
Earl W. Todd +2 more
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Action of Tetracycline on the Level of Properdin
Nature, 1961THE influence of antibiotics on the formation of antibodies has been studied by many authors. Recently, Patocka et al.1 published a paper describing the inhibitory effect of tetracycline on the formation of specific antibodies of various types in infections or after immunization with brucellae, the influenza virus and herpes in laboratory animals ...
Vl. Kubelka, M. Rybák
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Solid phase radioimmunoassay of properdin
Immunochemistry, 1973Abstract This report describes a solid phase radioimmunoassay for measuring properdin concentration, independent of other proteins in the properdin system. Polystyrene tubes are coated with mono-specific rabbit antiserum to human properdin. The competitive binding of increasing concentrations of unlabeled properdin (10–50 ng) and a constant amount of
Ira Goodkofsky +2 more
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2018
Properdin, a 53 kDa glycoprotein, is a key positive regulator of the alternative pathway by significantly increasing the half-life of the C3 and C5 convertases. Properdin is also an initiator of the alternative pathway. Unlike most complement proteins, properdin is produced primarily by leucocytes rather than hepatocytes, and circulates at 4–25 μg/mL ...
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Properdin, a 53 kDa glycoprotein, is a key positive regulator of the alternative pathway by significantly increasing the half-life of the C3 and C5 convertases. Properdin is also an initiator of the alternative pathway. Unlike most complement proteins, properdin is produced primarily by leucocytes rather than hepatocytes, and circulates at 4–25 μg/mL ...
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Properdin — Its Biologic Importance
New England Journal of Medicine, 1972IN the classical complement system, complement action is initiated by immune complexes through the activation of C1, the first component of complement.
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