Results 41 to 50 of about 149,099 (355)

Incidence of tolerance in children undergoing repeated administration of propofol for proton radiation therapy: a retrospective study

open access: yesBMC Anesthesiology, 2018
Background Propofol is an excellent hypnotic drug for use in repeated radiation procedures in young children. To date, tolerance to propofol generally does not develop in pediatric patients undergoing radiation therapy.
RyungA Kang   +5 more
doaj   +1 more source

Effect of Propofol on breast Cancer cell, the immune system, and patient outcome

open access: yesBMC Anesthesiology, 2018
Breast cancer is the second leading cause of cancer death in women. Surgery is the first line of treatment for breast cancer. Retrospective clinical studies suggest that the type of anesthesia administered during oncological surgery may influence patient
Ru Li, Hengrui Liu, J. Dilger, Jun Lin
semanticscholar   +1 more source

The effects of repeated propofol anesthesia on spatial memory and long-term potentiation in infant rats under hypoxic conditions

open access: yesGenes and Diseases, 2020
Propofol is widely used as an intravenous drug for induction and maintenance in general anesthesia. Hypoxemia is a common complication during perianesthesia.
Mang Sun   +4 more
doaj   +1 more source

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

open access: yesAdvanced Healthcare Materials, EarlyView.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer   +17 more
wiley   +1 more source

Propofol inhibits proliferation and epithelial-mesenchymal transition of MCF-7 cells by suppressing miR-21 expression

open access: yesArtificial Cells, Nanomedicine, and Biotechnology, 2019
Breast cancer is a common malignant tumor with a high incidence of recurrence and metastasis. It has been reported that propofol has certain anti-breast cancer effects, but the intrinsic molecular mechanism remains unclear.
Qing Du   +5 more
doaj   +1 more source

The Effect of Sevoflurane Plus Propofol on Pain and Complications after Laminectomy: A Randomized Double Blind Clinical Trial [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2017
Introduction: Pain is one of the most important reasons for the patients concern after surgery. The perfect sedative should have properties like rapid onset, least pain and adverse effects.
Aminolah Vasigh   +4 more
doaj   +1 more source

The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients

open access: yesFrontiers in Pharmacology, 2022
It is generally accepted that geriatric patients are more sensitive to propofol than adults; thus, a dose-adjusted propofol is recommended for these patients during the induction of anesthesia.
Hua Yang   +6 more
doaj   +1 more source

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

open access: yesBioMed Research International, 2018
Propofol is an intravenous short-acting anesthetic widely used to induce and maintain general anesthesia and to provide procedural sedation. The potential for propofol dependency and abuse has been recognized, and several cases of accidental overdose and
R. Dinis-Oliveira
semanticscholar   +1 more source

Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction

open access: yesAdvanced Science, EarlyView.
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu   +14 more
wiley   +1 more source

Propofol inhibits parthanatos via ROS–ER–calcium–mitochondria signal pathway in vivo and vitro

open access: yesCell Death and Disease, 2018
Parthanatos is a new form of programmed cell death. It has been recognized to be critical in cerebral ischemia–reperfusion injury, and reactive oxygen species (ROS) can induce parthanatos.
Hanhui Zhong   +10 more
semanticscholar   +1 more source

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