Clinical outcomes of remote ischemic preconditioning prior to cardiac surgery: A meta‐analysis of randomized controlled trials [PDF]
, 2017 Background Multiple randomized controlled trials of remote ischemic preconditioning ( RIPC ) prior to cardiac surgery have failed to demonstrate clinical benefit. The aim of this updated
Bole, Indra +3 more
core +2 more sources
A Transformer-based Prediction Method for Depth of Anesthesia During Target-controlled Infusion of Propofol and Remifentanil [PDF]
arXiv, 2023 Accurately predicting anesthetic effects is essential for target-controlled infusion systems. The traditional (PK-PD) models for Bispectral index (BIS) prediction require manual selection of model parameters, which can be challenging in clinical settings. Recently proposed deep learning methods can only capture general trends and may not predict abrupt
arxiv
Unconsciousness reconfigures modular brain network dynamics [PDF]
, 2020 The dynamic core hypothesis posits that consciousness is correlated with simultaneously integrated and differentiated assemblies of transiently synchronized brain regions. We represented time-dependent functional interactions using dynamic brain networks, and assessed the integrityof the dynamic core by means of the flexibility and largest multilayer ...
arxiv +1 more source
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Breast cancer is a common malignant tumor with a high incidence of recurrence and metastasis. It has been reported that propofol has certain anti-breast cancer effects, but the intrinsic molecular mechanism remains unclear.
Qing Du +5 more
doaj +1 more source
The Effect of Sevoflurane Plus Propofol on Pain and Complications after Laminectomy: A Randomized Double Blind Clinical Trial [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Pain is one of the most important reasons for the patients concern after surgery. The perfect sedative should have properties like rapid onset, least pain and adverse effects.
Aminolah Vasigh +4 more
doaj +1 more source
Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate [PDF]
, 2009 Background: Conventional compartmental pharmacokinetic models wrongly assume instantaneous drug mixing in the central compartment, resulting in a flawed prediction of drug disposition for the first minutes, and the flaw affects pharmacodynamic modeling ...
Hagihira, Satoshi +5 more
core +2 more sources
Depth of anesthesia control using internal model control techniques [PDF]
, 2010 The major difficulty in the design of closed-loop control during anaesthesia is the inherent patient variability due to differences in demographic and drug tolerance.
Anna, Shahab, Wen, Peng
core +1 more source
Prediction of Individual Propofol Requirements based on Preoperative EEG Signals [PDF]
arXiv, 2020 The patient must be given an adequate amount of propofol for safe surgery since overcapacity and low capacity cause accidents. However, the sensitivity of propofol varies from patient to patient, making it very difficult to determine the propofol requirements for anesthesia.
arxiv
The influence of storage time and temperature on propofol concentrations in canine blood and plasma [PDF]
PeerJ, 2017 Propofol is an intravenous anesthetic commonly used due to its favorable pharmacokinetic and pharmacodynamic profile. There are discrepancies in the literature about the most appropriate sample for determining propofol concentrations. Although plasma has
Sherry Cox +4 more
doaj +2 more sources
Frontiers in Bioscience-Landmark, 2022 Background: Postoperative cognitive dysfunction (POCD) is a common complication after surgery and anesthesia. In this study, we aimed to determine the neuroprotective mechanism of Sirtuin 3 (SIRT3) and propofol in POCD. Methods: The cognitive dysfunction
Shang Li +7 more
doaj +1 more source