Results 11 to 20 of about 18,081 (213)

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors. [PDF]

PLoS ONE, 2015
Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins.
Bruno Ramos-Molina, Adam N Lick, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Tiwari, Naglaa Salem El-Sayed, Keykavous Parang, Iris Lindberg   +7 more
doaj   +1 more source

Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury

Biomolecules, 2023
Despite advances in treatment options, such as corticosteroid administration and less invasive respiratory support, bronchopulmonary dysplasia (BPD) remains an important prognostic factor in preterm infants.
Shin Kato, Osuke Iwata, Hiroyuki Kato, Satoko Fukaya, Yukari Imai, Shinji Saitoh   +5 more
doaj   +1 more source

Hysteretic behavior of proprotein convertase 1/3 (PC1/3). [PDF]

PLoS ONE, 2011
The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes.
Marcelo Y Icimoto, Nilana M Barros, Juliana C Ferreira, Marcelo F Marcondes, Douglas Andrade, Mauricio F Machado, Maria A Juliano, Wagner A Júdice, Luiz Juliano, Vitor Oliveira   +9 more
doaj   +1 more source

Sex difference in circulating PCSK9 and its clinical implications

Frontiers in Pharmacology, 2022
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a proprotein convertase that increases plasma low-density lipoprotein cholesterol (LDL-C) levels by triggering the degradation of LDL receptors (LDLRs).
Fang Jia, Si-Fan Fei, De-Bing Tong, Cong Xue, Jian-Jun Li   +4 more
doaj   +1 more source

Diversity in Proprotein Convertase Reactivity among Human Papillomavirus Types

Viruses, 2023
The cleavage of viral surface proteins by furin is associated with some viruses’ high virulence and infectivity. The human papillomavirus (HPV) requires the proteolytic processing of its capsid proteins for activation before entry.
Gonzalo Izaguirre, Lam Minh Uyen Phan, Shaan Asif, Samina Alam, Craig Meyers, Lijun Rong   +5 more
doaj   +1 more source

A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity. [PDF]

PLoS ONE, 2014
Four siblings presented with congenital diarrhea and various endocrinopathies. Exome sequencing and homozygosity mapping identified five regions, comprising 337 protein-coding genes that were shared by three affected siblings. Exome sequencing identified
Michael Wilschanski, Montaser Abbasi, Elias Blanco, Iris Lindberg, Michael Yourshaw, David Zangen, Itai Berger, Eyal Shteyer, Orit Pappo, Benjamin Bar-Oz, Martin G Martín, Orly Elpeleg   +11 more
doaj   +1 more source

Insight into the Evolving Role of PCSK9

Metabolites, 2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells.
Mateusz Maligłówka, Michał Kosowski, Marcin Hachuła, Marcin Cyrnek, Łukasz Bułdak, Marcin Basiak, Aleksandra Bołdys, Grzegorz Machnik, Rafał Jakub Bułdak, Bogusław Okopień   +9 more
doaj   +1 more source

Use of PCSK9 Inhibitors in Solid Organ Transplantation Recipients

JACC: Case Reports, 2020
Standard lipid-lowering therapies in solid organ transplantations pose challenges due to interactions with immunosuppressants. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid-lowering therapies with ...
Bruce A. Warden, PharmD, Tina Kaufman, PhD, PA-C, Jessica Minnier, PhD, P. Barton Duell, MD, Sergio Fazio, MD, PhD, Michael D. Shapiro, DO, MCR   +5 more
doaj   +1 more source

Hepatic Proprotein Convertases Modulate HDL Metabolism [PDF]

Cell Metabolism, 2007
The risk of atherosclerosis is inversely associated with plasma levels of high-density lipoprotein cholesterol (HDL-C). However, HDL metabolism is incompletely understood, and there are few effective approaches to modulate HDL-C levels. Here we show that inhibition in the liver of the classical proprotein convertases (PCs), but not the atypical PCs S1P
Jin, Weijun, Wang, Xun, Millar, John S., Quertermous, Thomas, Rothblat, George H., Glick, Jane M., Rader, Daniel J.   +6 more
openaire   +2 more sources