Results 191 to 200 of about 18,081 (213)
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Proprotein Convertases in Health and Disease
New England Journal of Medicine, 2011Proteases that process larger precursor proteins into smaller functional proteins are involved in a wide range of physiologic processes. Derangements in the function of these enzymes play a role in many diseases.
Andrew W, Artenstein, Steven M, Opal
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Proprotein Convertases in Gynecological Cancers
Colloquium Series on Protein Activation and Cancer, 2012ABSTRACT Gynecological cancers include neoplasias of internal female genital organs, mainly ovarian, endometrial and cervical tumors, and cancers of the external female genital structures. Current scientific evidence indicates that both up- and down-regulation of the expression of PCs are part of the multiple changes occurring in these gynecological ...
Andres J.P. Klein-Szanto +2 more
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Proprotein convertase subtilisin/kexin type 9 inhibition
Current Opinion in Lipidology, 2012There are now ample data that demonstrate that inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) can safely lower LDL cholesterol synergistically with statins. Considering that PCSK9 was first identified less than a decade ago, the last few years have shown rapid and remarkable advancements in our understanding and knowledge of the ...
David A, Marais +4 more
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Viral envelope glycoprotein processing by proprotein convertases
Antiviral Research, 2013The proprotein convertases (PCs) are a family of nine mammalian enzymes that play key roles in the maintenance of cell homeostasis by activating or inactivating proteins via limited proteolysis under temporal and spatial control. A wide range of pathogens, including major human pathogenic viruses can hijack cellular PCs for their own purposes.
Pasquato Antonella +4 more
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Characterization of proADAMTS5 processing by proprotein convertases
The International Journal of Biochemistry & Cell Biology, 2009ADAMTS5 (aggrecanase-2), a key metalloprotease mediating cartilage destruction in arthritis, is synthesized as a zymogen, proADAMTS5. We report a detailed characterization of the propeptide excision mechanism and demonstrate that it is a major regulatory step with unusual characteristics. Using furin-deficient cells and a furin inhibitor, we found that
Jean-Michel, Longpré +5 more
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The Proprotein Convertases, 20 Years Later
2011The proprotein convertases (PCs) are secretory mammalian serine proteinases related to bacterial subtilisin-like enzymes. The family of PCs comprises nine members, PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9 (Fig. 3.1). While the first seven PCs cleave after single or paired basic residues, the last two cleave at non-basic residues ...
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Proprotein Convertase 1/3 Deficiency
The Indian Journal of Pediatrics, 2017Gurinder Kumar +2 more
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