Natriuretic Peptides in the Cardiovascular System. Multifaceted Roles in Physiology, Pathology and Therapeutics [PDF]
, 2019 The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological ...
Rubattu, Speranza, Volpe, Massimo
core +1 more source
Mouse models of human proprotein convertase insufficiency.
Endocrine reviews, 2020 The kexin-like proprotein convertases perform the initial proteolytic cleavages that ultimately generate a variety of different mature peptide and proteins, ranging from brain neuropeptides, to endocrine peptide hormones, to structural proteins, among ...
Manita Shakya, I. Lindberg
semanticscholar +1 more source
Functional Regulation of Semaphorin Receptors by Proprotein Convertases [PDF]
Journal of Biological Chemistry, 2003 PLEXIN genes encode receptors for secreted and membrane-bound semaphorins. It was proposed that the extracellular domain of plexins acts as an inhibitory moiety, preventing receptor activation. Here we show that plexin-B1 and plexin-B2 undergo proteolytic processing in their extracellular portion, thereby converting single-chain precursors into non ...
ARTIGIANI, Stefania +7 more
openaire +5 more sources
The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure:BIOSTAT-CHF Subanalysis [PDF]
, 2017 Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds low-density lipoprotein receptor (LDLR), preventing its recycling. PCSK9 is a risk predictor and a biotarget in atherosclerosis progression.
Anker, Stefan D. +16 more
core +4 more sources
A PCSK9 e sua relevância clínica com os novos alvos terapêuticos contra a dislipidemia [PDF]
, 2012 This is a remarkable progress; since the finding of statins, there was no new way of reducing, significantly, cholesterol and LDL fraction. It is also clear that this decrease, by statins, is related to future cardiovascular lesions, being useful in its ...
Ferreira, Carlos Eduardo dos Santos +2 more
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The proprotein convertase furin is required for trophoblast syncytialization [PDF]
Cell Death & Disease, 2013 The multinucleated syncytial trophoblast, which forms the outermost layer of the placenta and serves multiple functions, is differentiated from and maintained by cytotrophoblast cell fusion. Deficiencies in syncytial trophoblast differentiation or maintenance likely contribute to intrauterine growth restriction and pre-eclampsia, two common gestational
Zhi Zhou +8 more
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Perkembangan Implikasi Biologi dan Klinis Proprotein Convertase Subtilisin-Kexin 9
Majalah Kardiologi Indonesia, 2017 Pada tahun 2003 Proprotein Convertase Subtilisin-Kexin 9 (PCSK9) berhasil diidentifikasi.1 PCSK9 berfungsi meningkatkan kadar LDL Cholesterol (LDL-C) melalui degradasi LDL Receptor (LDLR).2 Penemuan PCSK9 telah merevolusi serta merupakan perkembangan ...
doaj +1 more source
Effect of alirocumab on lipids and lipoproteins in individuals with metabolic syndrome without diabetes: Pooled data from 10 phase 3 trials. [PDF]
, 2018 AimsThis analysis assessed the efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, in patients with or without metabolic syndrome (MetS) using pooled data from 10 phase 3 ODYSSEY trials.Materials and methodsData ...
Bujas-Bobanovic, Maja +6 more
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Identification of proprotein convertase substrates using genome-wide expression correlation analysis
BMC Genomics, 2011 Background Subtilisin/kexin-like proprotein convertase (PCSK) enzymes have important regulatory function in a wide variety of biological processes. PCSKs proteolytically process at a target sequence that contains basic amino acids arginine and lysine ...
Turpeinen Hannu +6 more
doaj +1 more source
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model [PDF]
, 2009 BACKGROUND: The secretory basic amino acid-specific proprotein convertases (PCs) have often been associated with cancer/metastasis. By controlling the cleavage of cancer-associated proteins, PCs play key roles in multiple steps of cancer development ...
Annik Prat +4 more
core +3 more sources