Results 61 to 70 of about 18,081 (213)
British Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth +16 more
wiley +1 more source
Potential of PCSK9 as a new target for the management of LDL cholesterol
Research Reports in Clinical Cardiology, 2015 Guiliana Mombelli, Samuela Castelnuovo, Chiara PavanelloCardiovascular Department, Dyslipidemia Center, Azienda Ospedaliera Niguarda Cà Granda, Milan, ItalyAbstract: A large proportion of patients at high risk for cardiovascular disease continue ...
Mombelli G, Castelnuovo S, Pavanello C
doaj
Transgenic Overexpression of the Proprotein Convertase Furin Enhances Skin Tumor Growth
Neoplasia: An International Journal for Oncology Research, 2012 Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression.
Jian Fu +5 more
doaj +1 more source
Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Dyslipidaemia is among the major risk factors for atherosclerotic cardiovascular disease. Paradoxically, higher cholesterol levels are associated with better survival in heart failure (HF) of any aetiology. Because cholesterol is an integral component of skeletal muscle structure, one possible explanation involves the interplay ...
Ryosuke Sato +6 more
wiley +1 more source
Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors [PDF]
Canadian Medical Association Journal, 2019 PCSK9 is a protease that degrades hepatic LDL-C receptors. Evolocumab and alirocumab are fully human monoclonal antibodies administered as subcutaneous injections that inhibit PCSK9, preserving receptor availability to clear circulating LDL-C.[1][1],[2][2] In randomized, placebo-controlled ...
Derek, Leong, Peter E, Wu
openaire +2 more sources
Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells [PDF]
, 2021 Zsuzsanna Ortutay +5 more
openalex +1 more source
Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Cleavage activates Dispatched for Sonic Hedgehog ligand release
eLife, 2018 Hedgehog ligands activate an evolutionarily conserved signaling pathway that provides instructional cues during tissue morphogenesis, and when corrupted, contributes to developmental disorders and cancer.
Daniel P Stewart +7 more
doaj +1 more source
MedComm, Volume 7, Issue 2, February 2026.ABSTRACT Significant residual cardiovascular risk persists in patients diagnosed with coronary artery disease despite intensive lipid‐lowering therapy. Although insulin resistance (IR) is an established epidemiological risk factor, the biological mechanisms by which it promotes plaque destabilization remain poorly understood.
Yue Yu +11 more
wiley +1 more source