Results 71 to 80 of about 38,575 (293)

From proprotein convertase subtilisin/kexin type 9 to its inhibition: state-of-the-art and clinical implications [PDF]

, 2016
Statins are recommended as first-line therapy for patients with hypercholesterolaemia. A sizable proportion of patients, however, does not reach therapeutic goals, is statin intolerant, or, despite optimal statin therapy, is at high risk of ischaemic ...
Alessandro, Sionis, CICCONE, Marco Matteo, DEVITO, FIORELLA, Dimitrios, Dimitroulis, Georg, Wolff, Hans, Busch, Michalina, Kołodziejczak, Navarese, Eliano Pio   +7 more
core   +1 more source

Cyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9

European Heart Journal, 2019
Aims Proprotein convertase subtilisin/kexin type-9 (PCSK9), a molecular determinant of low-density lipoprotein (LDL) receptor (LDLR) fate, has emerged as a promising therapeutic target for atherosclerotic cardiovascular diseases.
H. Jang, Sang Eun Lee, Jimin Yang, Hyun-Chae Lee, Dasom Shin, H. Lee, Jaewon Lee, Sooryeonhwa Jin, Soung-Hoon Kim, Seung Ji Lee, Jihye You, Hyun-Woo Park, Ky-Youb Nam, Sang-Hak Lee, Sahng-Wook Park, Jin-Soo Kim, Sang‐Yeob Kim, Yoo-Wook Kwon, S. Kwak, Han-Mo Yang, Hyo‐Soo Kim   +20 more
semanticscholar   +1 more source

In vitro characterization of the novel proprotein convertase PC7. [PDF]

Journal of Biological Chemistry, 1997
Biochemical and enzymatic characterization of the novel proprotein convertase rat PC7 (rPC7) was carried out using vaccinia virus recombinants overexpressed in mammalian BSC40 cells. Pro-PC7 is synthesized as a glycosylated zymogen (101 kDa) and processed into mature rPC7 (89 kDa) in the endoplasmic reticulum.
J S, Munzer, A, Basak, M, Zhong, A, Mamarbachi, J, Hamelin, D, Savaria, C, Lazure, G N, Hendy, S, Benjannet, M, Chrétien, N G, Seidah   +10 more
openaire   +3 more sources

Evaluation of adropin indices and PCSK9 in non-diabetic men with severe obstructive sleep apnea

Türk Biyokimya Dergisi
We aimed to investigate the relationship among proprotein convertase subtilisin/kexin type 9 (PCSK9), adropin levels, inflammation, and sleep variables in non-diabetic males with severe obstructive sleep apnea (OSA).
Deniz Levent, Aral Hale, Akdoğan Özlem, Arslan Hilmi Furkan, Yiğit Enes   +4 more
doaj   +1 more source

Gene editing therapy ready for cardiovascular diseases: opportunities, challenges, and perspectives

Medical Review, 2021
Gene editing nucleases (GENs), represented by CRISPR/Cas9, have become major tools in biomedical research and offer potential cures for many human diseases.
Zhou Jun, Ren Zhuoying, Xu Jie, Zhang Jifeng, Chen Y. Eugene   +4 more
doaj   +1 more source

Proprotein Convertase Processing Enhances Peroxidasin Activity to Reinforce Collagen IV [PDF]

, 2016
The basement membrane (BM) is a form of extracellular matrix that underlies cell layers in nearly all animal tissues. Type IV collagen, a major constituent of BMs, is critical for tissue development and architecture.
Bhave, Gautam, Colon, Selene
core   +2 more sources

Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

Journal of Internal Medicine, 2018
Diabetes mellitus is linked to premature mortality of virtually all causes. Furin is a proprotein convertase broadly involved in the maintenance of cellular homeostasis; however, little is known about its role in the development of diabetes mellitus and ...
C. Fernandez, J. Rysä, P. Almgren, J. Nilsson, G. Engström, M. Orho-Melander, H. Ruskoaho, O. Melander   +7 more
semanticscholar   +1 more source

Discovery and SAR analysis of phenylbenzo[d][1,3]dioxole-based proprotein convertase subtilisin/kexin type 9 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel therapeutic target for the development of cholesterol-lowering drugs.
Fahui Li, Lihui Zhang, Jinhong Feng, Lei Zhang   +3 more
doaj   +1 more source

Role of Proprotein Convertases in Prostate Cancer Progression

Neoplasia, 2012
Better understanding of the distinct and redundant functions of the proprotein convertase (PC) enzyme family within pathophysiological states has a great importance for potential therapeutic strategies. In this study, we investigated the functional redundancy of PCs in prostate cancer in the commonly used androgen-sensitive LNCaP and the androgen ...
François Boudreau, François D'Anjou, Robert Day, Roxane Desjardins, Frédéric Couture   +4 more
openaire   +4 more sources

Proprotein Convertase Subtilisin Kexin 9 Inhibitors [PDF]

Cardiology Clinics, 2018
High levels of low-density lipoprotein cholesterol (LDL-C) are directly associated with an increased risk of cardiovascular disease. Reducing LDL-C levels reduces the incidence of cardiovascular events. Several lipid-lowering approaches are available to achieve the LDL-C levels recommended by current guidelines, statins being the first-line therapy ...
A. Pirillo, A. L. Catapano
openaire   +3 more sources