Results 81 to 90 of about 38,575 (293)

P8 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 LEVELS AND ARTERIAL FUNCTION

Artery Research, 2017
Purpose/Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are modestly but significantly associated with increased risk of total cardiovascular events.
Losif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, John Skoumas, Nikitas Skliros, Magkas Nikolaos, Antigoni Miliou, Dimitrios Tousoulis   +7 more
doaj   +1 more source

The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes [PDF]

, 2010
The cuticle of parasitic nematodes performs many critical functions and is essential for proper development and for protection from the host immune response.
Antony P. Page, Bernard, Blaxter, Chu, Cook, Fessler, Ford, Frand, Ghedin, Gillian McCormack, Gillian Stepek, Hawdon, Johnstone, Johnstone, Kingston, Kingston, Kramerova, Kramerova, Kress, Mieszczanek, Milstone, Nagano, Novelli, Novelli, Paesen, Page, Page, Poole, Priess, Redmond, Rhoads, Sasaki, Scott, Shamansky, Skuce, Stanssens, Studier, Thacker, Thacker, Thacker, Thacker, Thein, Wells, Winter   +43 more
core   +1 more source

Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies

Cardiovascular Research, 2019
Since the discovery of the role of proprotein convertase subtilisin kexin 9 (PCSK9) in the regulation of low-density lipoprotein cholesterol (LDL-C) in 2003, a paradigm shift in the treatment of hypercholesterolaemia has occurred. The PCSK9 secreted into
N. Seidah, A. Prat, A. Pirillo, A. Catapano, G. Norata   +4 more
semanticscholar   +1 more source

Proprotein Convertase Subtilisin/Kexin 9 as a Modifier of Lipid Metabolism in Atherosclerosis

Biomedicines, 2023
Despite being the most common treatment strategy in the management of atherosclerosis and subsequent cardiovascular disease, classical statin therapy has certain disadvantages, including numerous side effects.
Anastasia V. Poznyak, Vasily N. Sukhorukov, Ilya I. Eremin, Irina I. Nadelyaeva, Nikita A. Gutyrchik, Alexander N. Orekhov   +5 more
doaj   +1 more source

PCSK9 inhibitors : from discovery of a single mutation to a groundbreaking therapy of lipid disorders in one decade [PDF]

, 2017
Hypercholesterolemia is one of the main risk factors for coronary heart disease and significantly contributes to the high mortality associated with cardiovascular diseases.
Jankowski, Piotr, Jaworski, Krzysztof, Kosior, Dariusz A.   +2 more
core   +1 more source

The Proprotein Convertase PC7 [PDF]

Journal of Biological Chemistry, 2011
The zymogen activation mechanism and physiological functions of the most ancient and highly conserved basic amino acid-specific proprotein convertase 7 (PC7) are not known. Herein, we characterized the biosynthesis, subcellular localization, and trafficking of the membrane-bound full-length rat and human PC7. The prosegment of PC7 is primarily secreted
Nabil G. Seidah, Josée Hamelin, Estelle Rousselet, Maryssa Canuel, Suzanne Benjannet   +4 more
openaire   +3 more sources

Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome [PDF]

Diabetes & Metabolism Journal, 2018
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor.
Kwi-Hyun Bae, Sung Woo Kim, Yeon-Kyung Choi, Jung Beom Seo, Namkyun Kim, Chang-Yeon Kim, Won Kee Lee, Sungwoo Lee, Jung Guk Kim, In-Kyu Lee, Jang Hoon Lee, Keun-Gyu Park   +11 more
doaj   +1 more source

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

Frontiers in Pharmacology, 2022
Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and
Bianca E. Suur, Melody Chemaly, Moritz Lindquist Liljeqvist, Djordje Djordjevic, Djordje Djordjevic, Markus Stenemo, Otto Bergman, Eva Karlöf, Mariette Lengquist, Jacob Odeberg, Jacob Odeberg, Eva Hurt-Camejo, Eva Hurt-Camejo, Per Eriksson, Daniel F.J. Ketelhuth, Daniel F.J. Ketelhuth, Joy Roy, Ulf Hedin, Michael Nyberg, Ljubica Matic   +19 more
doaj   +1 more source

Proprotein Convertases Process Pmel17 during Secretion [PDF]

Journal of Biological Chemistry, 2011
Pmel17 is a melanocyte/melanoma-specific protein that traffics to melanosomes where it forms a fibrillar matrix on which melanin gets deposited. Before being cleaved into smaller fibrillogenic fragments the protein undergoes processing by proprotein convertases, a class of serine proteases that typically recognize the canonical motif RX(R/K)R↓.
Nathalie Vigneron, Nathalie Vigneron, Peter Cresswell, Peter Cresswell, Christoph Rahner, Ralf M. Leonhardt   +5 more
openaire   +3 more sources

Childhood Obesity and Familial Hypercholesterolemia: Genetic Diseases that Contribute to Cardiovascular Disease [PDF]

, 2014
Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency.
Caudle, Alyssa
core   +1 more source