Results 81 to 90 of about 18,081 (213)

Characterization of a quantitative method to measure free proprotein convertase subtilisin/kexin type 9 in human serum [PDF]

, 2014
Alexander Colbert, Amber Umble-Romero, Samantha P. Prokop, Ren Xu, John P. Gibbs, Susan Pederson   +5 more
openalex   +1 more source

Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors

International Journal of Biological Sciences, 2010
Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins. Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 ...
Sun Tian, Wu Jianhua
doaj  

Image_3_Association Between Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations and Cardiovascular Events in Cardiovascular Disease: A Systemic Review and Meta-Analysis.TIF

, 2021
Jiahui Liu (724342), Fangfang Fan (312738), Xingyu Luo (3684229), Wenjun Ji (822811), Yaokun Liu (11743949), Yan Zhang (8098), Bo Zheng (170888)   +6 more
openalex   +2 more sources

Therapeutic Strategies for Hypercholesterolemia

healthbook TIMES Das Schweizer Ärztejournal Journal Des Médecins Suisses
A high cholesterol level in the blood is associated with an increased risk of atherosclerosis and its related conditions such as heart attack and stroke.
Georg Noll, André Linka, Thomas Lüscher, Isabella Sudano   +3 more
doaj   +1 more source

TACE/ADAM‐17 maturation and activation of sheddase activity require proprotein convertase activity [PDF]

, 2003
Nadim Srour, Annie Lebel, Stéphanie McMahon, Isabelle Fournier, Martin Fugère, Robert Day, Claire M. Dubois   +6 more
openalex   +1 more source

Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis [PDF]

, 2020
Robert P. Giugliano, Terje R. Pedersen, Jeffrey L. Saver, Peter S. Sever, Anthony Keech, Erin A. Bohula, Sabina A. Murphy, Scott M. Wasserman, Narimon Honarpour, Huei Wang, Armando Lira Pineda, Marc S. Sabatine, on behalf of the FOURIER Investigators   +12 more
openalex   +1 more source

Proprotein Convertase FURIN Constrains Th2 Differentiation and Is Critical for Host Resistance against Toxoplasma gondii [PDF]

, 2014
Anna Oksanen, Saara Aittomäki, Dragana Janković, Zsuzsanna Ortutay, Kati Pulkkinen, Sanna Hämäläinen, Anne Rokka, Garry L. Corthals, Wendy T. Watford, Ilkka Junttila, John J. O’Shea, Marko Pesu   +11 more
openalex   +1 more source

Increased Valency Improves Inhibitory Activity of Peptides Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

, 2021
Benjamin J. Tombling, Carmen Lammi, Carlotta Bollati, Anna Anoldi, David J. Craik, Conan K. Wang   +5 more
openalex   +2 more sources

The effects of cholesterol-lowering drugs on neurocognitive function: systematic review and meta analysis

Frontiers in Neurology
ObjectiveTo investigate if cholesterol-lowering drugs exert effects on neurocognitive function.MethodsWe searched Pubmed, Embase and Cochrane Libarary from inception to March 23rd, 2023, and searched clinicaltrials.gov on January 23rd, 2024.
Kaiwei Li, Kaiwei Li, Ying Li, Xia Jiang, Ye Zhu, Ye Zhu   +5 more
doaj   +1 more source

Paclitaxel Treatment and Proprotein Convertase 1/3 (PC1/3) Knockdown in Macrophages is a Promising Antiglioma Strategy as Revealed by Proteomics and Cytotoxicity Studies [PDF]

, 2018
Marie Duhamel, Mélanie Rose, Franck Rodet, Adriana‐Natalia Murgoci, Lea Zografidou, Anne Régnier‐Vigouroux, Fabien Vanden Abeele, Firas Kobeissy, Serge Nataf, Laurent Pays, Maxence Wisztorski, Dáša Čı́žková, Isabelle Fournier, Michel Salzet   +13 more
openalex   +1 more source