Proprotein Convertases and the Complement System [PDF]
Frontiers in Immunology, 2022 Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó +3 more
doaj +5 more sources
Testicular Germ Cell Tumours and Proprotein Convertases. [PDF]
Cancers (Basel), 2022 Testicular Germ Cell Tumours (TGCT) are widely considered a “curable cancer” due to their exceptionally high survival rate, even if it is reduced by many years after the diagnosis due to metastases and relapses.
Velado-Eguskiza A +4 more
europepmc +7 more sources
The Role of Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response [PDF]
Frontiers in Immunology, 2021 Proprotein convertases (PC) are a family of 9 serine proteases involved in the processing of cellular pro-proteins. They trigger the activation, inactivation or functional changes of many hormones, neuropeptides, growth factors and receptors.
Mélanie Rose +2 more
exaly +5 more sources
Role of Proprotein Convertases in Prostate Cancer Progression [PDF]
Neoplasia: An International Journal for Oncology Research, 2012 Better understanding of the distinct and redundant functions of the proprotein convertase (PC) enzyme family within pathophysiological states has a great importance for potential therapeutic strategies.
Frédéric Couture +4 more
doaj +6 more sources
Proprotein convertases in high-density lipoprotein metabolism. [PDF]
Biomark Res, 2013 The proprotein convertase subtilisin/kexins (PCSKs) are a serine endopeptidase family. PCSK members cleave amino acid residues and modulate the activity of precursor proteins.
Choi S, Korstanje R.
europepmc +8 more sources
How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread? [PDF]
Viruses, 2021 Inhibition of the binding of enveloped viruses surface glycoproteins to host cell receptor(s) is a major target of vaccines and constitutes an efficient strategy to block viral entry and infection of various host cells and tissues. Cellular entry usually
Nabil G. Seidah +2 more
doaj +4 more sources
In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23 [PDF]
Frontiers in Endocrinology, 2021 Fibroblast growth factor 23 (FGF23) is a hormone secreted from fully differentiated osteoblasts and osteocytes that inhibits phosphate reabsorption by kidney proximal tubules.
Omar Al Rifai +9 more
doaj +3 more sources
The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases [PDF]
Viruses, 2019 A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the constitutive protein secretion pathway in order to regulate their cell entry mechanism and infectivity. Surface proteins of enveloped, as well as non-enveloped, viruses
Gonzalo Izaguirre
doaj +3 more sources
Hepatic proprotein convertases modulate HDL metabolism. [PDF]
Cell Metab, 2007 SummaryThe risk of atherosclerosis is inversely associated with plasma levels of high-density lipoprotein cholesterol (HDL-C). However, HDL metabolism is incompletely understood, and there are few effective approaches to modulate HDL-C levels.
Jin W +6 more
europepmc +6 more sources
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. [PDF]
PLoS ONE, 2013 Proprotein convertases (PCs) is a protein family which includes nine highly specific subtilisin-like serine endopeptidases in mammals. The system of PCs is involved in carcinogenesis and levels of PC mRNAs alter in cancer, which suggests expression ...
Ilya V Demidyuk +9 more
doaj +3 more sources