Proprotein Convertases and the Complement System [PDF]
Frontiers in Immunology, 2022 Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó +3 more
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How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread? [PDF]
Viruses, 2021 Inhibition of the binding of enveloped viruses surface glycoproteins to host cell receptor(s) is a major target of vaccines and constitutes an efficient strategy to block viral entry and infection of various host cells and tissues. Cellular entry usually
Nabil G. Seidah +2 more
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What Are the Roles of Proprotein Convertases in the Immune Escape of Tumors? [PDF]
Biomedicines, 2022 Protein convertases (PCs) play a significant role in post-translational procedures by transforming inactive precursor proteins into their active forms. The role of PCs is crucial for cellular homeostasis because they are involved in cell signaling.
Elham Mehranzadeh +3 more
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In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23 [PDF]
Frontiers in Endocrinology, 2021 Fibroblast growth factor 23 (FGF23) is a hormone secreted from fully differentiated osteoblasts and osteocytes that inhibits phosphate reabsorption by kidney proximal tubules.
Omar Al Rifai +9 more
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Testicular Germ Cell Tumours and Proprotein Convertases. [PDF]
Cancers (Basel), 2022 Testicular Germ Cell Tumours (TGCT) are widely considered a “curable cancer” due to their exceptionally high survival rate, even if it is reduced by many years after the diagnosis due to metastases and relapses. The most common therapeutic approach to TGCTs has not changed in the last 50 years despite its multiple long-term side effects, and because it
Velado-Eguskiza A +4 more
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Role of Proprotein Convertases in Prostate Cancer Progression [PDF]
Neoplasia: An International Journal for Oncology Research, 2012 Better understanding of the distinct and redundant functions of the proprotein convertase (PC) enzyme family within pathophysiological states has a great importance for potential therapeutic strategies.
Frédéric Couture +4 more
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The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases [PDF]
Viruses, 2019 A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the constitutive protein secretion pathway in order to regulate their cell entry mechanism and infectivity. Surface proteins of enveloped, as well as non-enveloped, viruses
Gonzalo Izaguirre
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The Role of Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response [PDF]
Frontiers in Immunology, 2021 Proprotein convertases (PC) are a family of 9 serine proteases involved in the processing of cellular pro-proteins. They trigger the activation, inactivation or functional changes of many hormones, neuropeptides, growth factors and receptors.
Mélanie Rose +3 more
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Proprotein convertases process Pmel17 during secretion. [PDF]
J Biol Chem, 2011 Pmel17 is a melanocyte/melanoma-specific protein that traffics to melanosomes where it forms a fibrillar matrix on which melanin gets deposited. Before being cleaved into smaller fibrillogenic fragments the protein undergoes processing by proprotein convertases, a class of serine proteases that typically recognize the canonical motif RX(R/K)R↓.
Leonhardt RM +3 more
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On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications [PDF]
Biomolecular Concepts, 2011 There is increasing interest in the therapeutic targeting of proteases for the treatment of important diseases. Additionally new protein-based therapeutic strategies have the potential to widen the available treatments against these pathologies.
Couture Frédéric +2 more
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