Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases [PDF]
Neoplasia: An International Journal for Oncology Research, 2013 The proprotein convertases (PCs) furin and PACE4 process numerous substrates involved in tumor growth, invasion, and metastasis. We have previously shown that PCs increase the susceptibility to chemical skin carcinogenesis. Because of the human relevancy
Jian Fu +7 more
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Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors [PDF]
International Journal of Biological Sciences, 2010 Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins. Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 ...
Sun Tian, Wu Jianhua
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Inhibition of the proprotein convertases represses the invasiveness of human primary melanoma cells with altered p53, CDKN2A and N-Ras genes. [PDF]
PLoS ONE, 2010 Altered tumor suppressor p53 and/or CDKN2A as well as Ras genes are frequently found in primary and metastatic melanomas. These alterations were found to be responsible for acquisition of invasive and metastatic potential through their defective ...
Claude Lalou +9 more
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Proprotein convertases process Pmel17 during secretion. [PDF]
J Biol Chem, 2011 Pmel17 is a melanocyte/melanoma-specific protein that traffics to melanosomes where it forms a fibrillar matrix on which melanin gets deposited. Before being cleaved into smaller fibrillogenic fragments the protein undergoes processing by proprotein convertases, a class of serine proteases that typically recognize the canonical motif RX(R/K)R↓.
Leonhardt RM +3 more
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Targeting proprotein convertases in furin‐rich lung cancer cells results in decreased in vitro and in vivo growth [PDF]
Molecular Carcinogenesis, 2017 Andres J Klein-szanto
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What Are the Roles of Proprotein Convertases in the Immune Escape of Tumors? [PDF]
Biomedicines, 2022 Protein convertases (PCs) play a significant role in post-translational procedures by transforming inactive precursor proteins into their active forms. The role of PCs is crucial for cellular homeostasis because they are involved in cell signaling.
Elham Mehranzadeh +3 more
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Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration. [PDF]
PLoS ONE, 2010 BACKGROUND: In zebrafish, vascular endothelial growth factor-C precursor (proVEGF-C) processing occurs within the dibasic motif HSIIRR(214) suggesting the involvement of one or more basic amino acid-specific proprotein convertases (PCs) in this process ...
Abdel-Majid Khatib +10 more
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Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases [PDF]
BMC Cancer, 2005 Background The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors.
Marcus Victoria +9 more
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The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9 [PDF]
Pharmacological Reviews, 2017 The secretory proprotein convertase (PC) family comprises nine members, as follows: PC1/3, PC2, furin, PC4, PC5/6, paired basic amino acid cleaving enzyme 4, PC7, subtilisin kexin isozyme 1/site 1 protease (SKI-1/S1P), and PC subtilisin/kexin type 9 (PCSK9).
Stefan Prost +4 more
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Characterization of Proprotein Convertases and Their Involvement in Virus Propagation [PDF]
Activation of Viruses by Host Proteases, 2018 Proprotein convertases (PCs), also known as eukaryotic subtilases, are a group of serine proteases comprising furin (PACE), PC1 (PC3), PC2, PC4, PACE4, PC5 (PC6), and PC7 (LPC, PC8) that generate bioactive proteins and peptides, such as hormones ...
Garten W.
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