Results 11 to 20 of about 8,088 (248)

Proprotein convertases in high-density lipoprotein metabolism. [PDF]

Biomark Res, 2013
The proprotein convertase subtilisin/kexins (PCSKs) are a serine endopeptidase family. PCSK members cleave amino acid residues and modulate the activity of precursor proteins. Evidence from patients and animal models carrying genetic alterations in PCSK members show that PCSK members are involved in various metabolic processes.
Choi S, Korstanje R.
europepmc   +7 more sources

Hepatic proprotein convertases modulate HDL metabolism. [PDF]

Cell Metab, 2007
The risk of atherosclerosis is inversely associated with plasma levels of high-density lipoprotein cholesterol (HDL-C). However, HDL metabolism is incompletely understood, and there are few effective approaches to modulate HDL-C levels. Here we show that inhibition in the liver of the classical proprotein convertases (PCs), but not the atypical PCs S1P
Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ.   +6 more
europepmc   +4 more sources

Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors [PDF]

International Journal of Biological Sciences, 2010
Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins. Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 ...
Sun Tian, Wu Jianhua
doaj   +2 more sources

Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. [PDF]

PLoS ONE, 2013
Proprotein convertases (PCs) is a protein family which includes nine highly specific subtilisin-like serine endopeptidases in mammals. The system of PCs is involved in carcinogenesis and levels of PC mRNAs alter in cancer, which suggests expression ...
Ilya V Demidyuk, Andrey V Shubin, Eugene V Gasanov, Alexander M Kurinov, Vladimir V Demkin, Tatyana V Vinogradova, Marina V Zinovyeva, Alexander V Sass, Irina B Zborovskaya, Sergey V Kostrov   +9 more
doaj   +2 more sources

Specific and Selective Inhibitors of Proprotein Convertases Engineered by Transferring Serpin B8 Reactive-Site and Exosite Determinants of Reactivity to the Serpin α1PDX. [PDF]

Biochemistry, 2019
Izaguirre G, Arciniega M, Quezada AG.
europepmc   +3 more sources

The proprotein convertase encoded by amontillado (amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH. [PDF]

PLoS Genetics, 2010
Peptide hormones are potent signaling molecules that coordinate animal physiology, behavior, and development. A key step in activation of these peptide signals is their proteolytic processing from propeptide precursors by a family of proteases, the ...
Jeanne M Rhea, Christian Wegener, Michael Bender   +2 more
doaj   +3 more sources

Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human [PDF]

Journal for ImmunoTherapy of Cancer
Background Immunotherapy approaches based on T cells provided breakthroughs in cancer treatment but could cause many immune-related adverse events, and their efficacy is limited for many cancers with an acquired dysfunction/exhaustion of T cells.
Delia Susan-Resiga, Nabil G Seidah, Nathalie Labrecque, Jean-Sebastien Delisle, Leila Jafarzadeh, Chloé Porcheron, Mailys Le Devehat, Anna Roubtsova, Hadi Bayat, Alexandra Evagelidis, Vatsal Sachan, Alexie Fonta Holder, Rachid Essalmani, Gabrielle Boudreau, Annik Prat, Rebecca Cusseddu, Jean-François Côté, Abdel-Majid Khatib   +17 more
doaj   +2 more sources

A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity. [PDF]

, 2014
Four siblings presented with congenital diarrhea and various endocrinopathies. Exome sequencing and homozygosity mapping identified five regions, comprising 337 protein-coding genes that were shared by three affected siblings. Exome sequencing identified
Abbasi, Montaser, Bar-Oz, Benjamin, Berger, Itai, Blanco, Elias, Elpeleg, Orly, Lindberg, Iris, Martín, Martin G, Pappo, Orit, Shteyer, Eyal, Wilschanski, Michael, Yourshaw, Michael, Zangen, David   +11 more
core   +20 more sources

Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors [PDF]

Nature Communications
Proprotein convertases (PCs), including furin and PC1/3 among nine mammalian homologues, mediate the maturation of numerous secreted substrates by proteolytic cleavage.
Rupert Klaushofer, Konstantin Bloch, Luisa Susanna Eder, Simone Marzaro, Mario Schubert, Eva Böttcher-Friebertshäuser, Hans Brandstetter, Sven O. Dahms   +7 more
doaj   +2 more sources

Insight into the Evolving Role of PCSK9

Metabolites, 2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells.
Mateusz Maligłówka, Michał Kosowski, Marcin Hachuła, Marcin Cyrnek, Łukasz Bułdak, Marcin Basiak, Aleksandra Bołdys, Grzegorz Machnik, Rafał Jakub Bułdak, Bogusław Okopień   +9 more
doaj   +1 more source