Hepatic proprotein convertases modulate HDL metabolism. [PDF]
Cell Metab, 2007 The risk of atherosclerosis is inversely associated with plasma levels of high-density lipoprotein cholesterol (HDL-C). However, HDL metabolism is incompletely understood, and there are few effective approaches to modulate HDL-C levels. Here we show that inhibition in the liver of the classical proprotein convertases (PCs), but not the atypical PCs S1P
Jin W +6 more
europepmc +4 more sources
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. [PDF]
PLoS ONE, 2013 Proprotein convertases (PCs) is a protein family which includes nine highly specific subtilisin-like serine endopeptidases in mammals. The system of PCs is involved in carcinogenesis and levels of PC mRNAs alter in cancer, which suggests expression ...
Ilya V Demidyuk +9 more
doaj +2 more sources
Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human [PDF]
Journal for ImmunoTherapy of CancerBackground Immunotherapy approaches based on T cells provided breakthroughs in cancer treatment but could cause many immune-related adverse events, and their efficacy is limited for many cancers with an acquired dysfunction/exhaustion of T cells.
Delia Susan-Resiga +17 more
doaj +2 more sources
A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity. [PDF]
, 2014 Four siblings presented with congenital diarrhea and various endocrinopathies. Exome sequencing and homozygosity mapping identified five regions, comprising 337 protein-coding genes that were shared by three affected siblings. Exome sequencing identified
Abbasi, Montaser +11 more
core +20 more sources
Activity-dependent extracellular proteolytic cascade cleaves the ECM component brevican to promote structural plasticity [PDF]
EMBO ReportsThe brain’s perineuronal extracellular matrix (ECM) is a crucial factor in maintaining the stability of mature brain circuitry. However, how activity-induced synaptic plasticity is achieved in the adult brain with a dense ECM is unclear.
Jeet Bahadur Singh +7 more
doaj +2 more sources
Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors [PDF]
Nature CommunicationsProprotein convertases (PCs), including furin and PC1/3 among nine mammalian homologues, mediate the maturation of numerous secreted substrates by proteolytic cleavage.
Rupert Klaushofer +7 more
doaj +2 more sources
Insight into the Evolving Role of PCSK9
Metabolites, 2022 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells.
Mateusz Maligłówka +9 more
doaj +1 more source
Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors. [PDF]
PLoS ONE, 2015 Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins.
Bruno Ramos-Molina +7 more
doaj +1 more source
Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration. [PDF]
PLoS ONE, 2010 BACKGROUND: In zebrafish, vascular endothelial growth factor-C precursor (proVEGF-C) processing occurs within the dibasic motif HSIIRR(214) suggesting the involvement of one or more basic amino acid-specific proprotein convertases (PCs) in this process ...
Abdel-Majid Khatib +10 more
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source