Results 31 to 40 of about 8,088 (248)
Hysteretic behavior of proprotein convertase 1/3 (PC1/3). [PDF]
PLoS ONE, 2011 The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes.
Marcelo Y Icimoto +9 more
doaj +1 more source
PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders. [PDF]
, 2016 Prohormone convertase 1/3, encoded by the PCSK1 gene, is a serine endoprotease that is involved in the processing of a variety of proneuropeptides and prohormones. Humans who are homozygous or compound heterozygous for loss-of-function mutations in PCSK1
core +2 more sources
Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs [PDF]
, 2010 Background: As important regulators of developmental and adult processes in metazoans, Fibroblast Growth Factor (FGF) proteins are potent signaling molecules whose activities must be tightly regulated.
Stathopoulos, Angelike, Tulin, Sarah
core +4 more sources
Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model. [PDF]
PLoS ONE, 2010 Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Improvement of treatment efficacy and decreased side effects through tumor-targeted drug delivery would be desirable.
Katarina Hajdin +4 more
doaj +1 more source
Journal of Lipid Research, 2021 In 2003, the sequences of mammalian proprotein convertase subtilisin/kexin type 9 (PCSK9) were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was synthesized as a precursor (proPCSK9) that undergoes autocatalytic cleavage in the ...
Nabil G. Seidah
doaj +1 more source
BMC Cancer, 2005 Background The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors.
Marcus Victoria +9 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Loxosceles spider venom contains Sphingomyelinase D (SMase D), the key toxin causing pathology. SMase D hydrolyzes the main component of lipid rafts, sphingomyelin, which changes the membrane microenvironment resulting in the activation of endogenous ...
Priscila Hess Lopes +2 more
doaj +1 more source
Proprotein Convertase Subtilisin Kexin 9 Inhibitors [PDF]
Cardiology Clinics, 2018 High levels of low-density lipoprotein cholesterol (LDL-C) are directly associated with an increased risk of cardiovascular disease. Reducing LDL-C levels reduces the incidence of cardiovascular events. Several lipid-lowering approaches are available to achieve the LDL-C levels recommended by current guidelines, statins being the first-line therapy ...
A. Pirillo, A. L. Catapano
openaire +2 more sources
SKI-1 and Furin Generate Multiple RGMa Fragments that Regulate Axonal Growth [PDF]
, 2012 SummaryThe nervous system is enormously complex, yet the number of cues that control axonal growth is surprisingly meager. Posttranslational modifications amplify diversity, but the degree to which they are employed is unclear.
Bermejo, Francisco Javier +8 more
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Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions [PDF]
, 2015 Substance P (SP) play a central role in nociceptive transmission and it is an agonist of the Neurokinin-1 receptor located in the lamina I of the spinal cord.
Beaudry, Francis +3 more
core +1 more source