Results 31 to 40 of about 5,923 (228)
Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model. [PDF]
PLoS ONE, 2010 Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Improvement of treatment efficacy and decreased side effects through tumor-targeted drug delivery would be desirable.
Katarina Hajdin +4 more
doaj +1 more source
Journal of Lipid Research, 2021 In 2003, the sequences of mammalian proprotein convertase subtilisin/kexin type 9 (PCSK9) were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was synthesized as a precursor (proPCSK9) that undergoes autocatalytic cleavage in the ...
Nabil G. Seidah
doaj +1 more source
BMC Cancer, 2005 Background The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors.
Marcus Victoria +9 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Loxosceles spider venom contains Sphingomyelinase D (SMase D), the key toxin causing pathology. SMase D hydrolyzes the main component of lipid rafts, sphingomyelin, which changes the membrane microenvironment resulting in the activation of endogenous ...
Priscila Hess Lopes +2 more
doaj +1 more source
Proprotein Convertase Subtilisin Kexin 9 Inhibitors [PDF]
Cardiology Clinics, 2018 High levels of low-density lipoprotein cholesterol (LDL-C) are directly associated with an increased risk of cardiovascular disease. Reducing LDL-C levels reduces the incidence of cardiovascular events. Several lipid-lowering approaches are available to achieve the LDL-C levels recommended by current guidelines, statins being the first-line therapy ...
A. Pirillo, A. L. Catapano
openaire +2 more sources
Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions [PDF]
, 2015 Substance P (SP) play a central role in nociceptive transmission and it is an agonist of the Neurokinin-1 receptor located in the lamina I of the spinal cord.
Beaudry, Francis +3 more
core +1 more source
The Dual α-Amidation System in Scorpion Venom Glands
Toxins, 2019 Many peptides in scorpion venoms are amidated at their C-termini. This post-translational modification is paramount for the correct biological function of ion channel toxins and antimicrobial peptides, among others.
Gustavo Delgado-Prudencio +3 more
doaj +1 more source
SKI-1 and Furin Generate Multiple RGMa Fragments that Regulate Axonal Growth [PDF]
, 2012 SummaryThe nervous system is enormously complex, yet the number of cues that control axonal growth is surprisingly meager. Posttranslational modifications amplify diversity, but the degree to which they are employed is unclear.
Bermejo, Francisco Javier +8 more
core +3 more sources
Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency. [PDF]
, 2013 Non-synonymous mutations affecting both alleles of PCSK1 (proprotein convertase 1/3) are associated with obesity and impaired prohormone processing. We report a proband who was compound heterozygous for a maternally inherited frameshift mutation and a ...
Bochukova, Elena +8 more
core +3 more sources
Prediction of proprotein convertase cleavage sites [PDF]
Protein Engineering, Design and Selection, 2004 Many secretory proteins and peptides are synthesized as inactive precursors that in addition to signal peptide cleavage undergo post-translational processing to become biologically active polypeptides. Precursors are usually cleaved at sites composed of single or paired basic amino acid residues by members of the subtilisin/kexin-like proprotein ...
Peter, Duckert +2 more
openaire +2 more sources