Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder. [PDF]
Mol Cell Biol, 2015 Kim W +13 more
europepmc +2 more sources
What lies ahead for the proprotein convertases?
Annals of the New York Academy of Sciences, 2011 Limited proteolysis of secretory proteins is performed by one or more of the nine‐membered proprotein convertase (PC) family: PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI‐1/S1P, and PCSK9. The first seven proteinases cleave proproteins at single or pairs of basic residues in the Golgi, secretory granules, cell surface, or endosomes.
N. Seidah
openaire +4 more sources
Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes. [PDF]
Immunity, 2013 Hipp MM +9 more
europepmc +2 more sources
A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity. [PDF]
, 2014 Four siblings presented with congenital diarrhea and various endocrinopathies. Exome sequencing and homozygosity mapping identified five regions, comprising 337 protein-coding genes that were shared by three affected siblings. Exome sequencing identified
Abbasi, Montaser +11 more
core +13 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1991 Suzanne Benjannet +4 more
openalex +2 more sources
Insight into the Evolving Role of PCSK9
Metabolites, 2022 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells.
Mateusz Maligłówka +9 more
doaj +1 more source
Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors. [PDF]
PLoS ONE, 2015 Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins.
Bruno Ramos-Molina +7 more
doaj +1 more source
American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 228-233, January 2023., 2023 Abstract Pulmonary arterial hypertension (PAH) is a disease characterized by pathological remodeling of the pulmonary vasculature causing elevated pulmonary artery pressures and ultimately, right ventricular failure from chronic pressure overload. Heterozygous pathogenic GDF2 (encoding bone morphogenetic protein 9 (BMP9)) variants account for some (>1%)
Paul Upton +5 more
wiley +1 more source
Human spermatozoa anti-proprotein convertase subtilisin/kexin type 4 synthesis using New Zealand rabbit for novel immunocontraception in males [PDF]
Investigative and Clinical Urology, 2019 Purpose: Proprotein convertase subtilisin/kexin type 4 (PCSK4, a 54-kDa protease) is expressed in the plasma membrane of the acrosome in human spermatozoa. It plays a critical role in penetrating the zona pellucida. Synthesis of human anti-PCSK4 might be
Dahril +3 more
doaj +1 more source
Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. [PDF]
PLoS ONE, 2014 KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging ...
Sitaram Harihar +4 more
doaj +1 more source