Results 181 to 190 of about 3,903,665 (206)

Renin and Prorenin Receptor in Hypertension: What’s New?

Current Hypertension Reports, 2010
The (pro)renin receptor, PRR, was initially characterized as a component of the renin-angiotensin system (RAS). PRR-bound renin and prorenin display increased enzymatic activity, and binding activates intracellular signaling, upregulating the expression of profibrotic proteins.
openaire   +2 more sources

Pathologic roles of prorenin and (pro)renin receptor in the eye

Frontiers in Bioscience, 2008
Recent reports indicated that tissue renin-angiotensin system (RAS) was upregulated and angiotensin II type 1 receptor signaling plays crucial roles in ocular inflammation and neovascularization; however, the precise mechanism for activating tissue RAS had not been defined until recently.
Shingo, Satofuka, Atsuhiro, Ichihara, Norihiro, Nagai, Kazuo, Tsubota, Hiroshi, Itoh, Susumu, Ishida   +5 more
openaire   +2 more sources

The role of the Prorenin Receptor in cancer progression

2020
Teodoro, Jose Guerreiro (Supervisor)
openaire   +1 more source

Prorenin and the (Pro)renin Receptor in Retinal Pathology

Current Hypertension Reviews, 2009
Blockade of angiotensin II (Ang II) has potential therapeutic benefit for ocular diseases including diabetic retinopathy and retinopathy of prematurity. Perhaps the most studied is diabetic retinopathy where angiotensin converting enzyme inhibition and angiotensin type 1 receptor blockade (AT1-RB) is beneficial.
Jennifer Wilkinson-Berka, Terri Allen, Antonia Miller   +2 more
openaire   +1 more source

Non-proteolytic activation of prorenin: activation by (pro)renin receptor and its inhibition by a prorenin prosegment, "decoy peptide"

Frontiers in Bioscience, 2008
Prorenin is the enzymatically inactive precursor of renin. Recent interest has focused on the nonproteolytic activation of prorenin by antibodies and renin/prorenin receptors since markedly increased levels of circulating prorenin have been associated with both physiological and pathological changes. Prorenin has been considered to be activated in vivo
M Nasir, Uddin, A H M Nurun, Nabi, Tsutomu, Nakagawa, Atsuhiro, Ichihara, Tadashi, Inagami, Fumiaki, Suzuki   +5 more
openaire   +2 more sources

[Systemic distribution of prorenin and its receptor].

Nihon rinsho. Japanese journal of clinical medicine, 2012
The (pro)renin receptor was first identified as a 350-amino acid protein with a single transmembrane domain. This receptor binds to prorenin to mediate its dual functions: activation of ERK1/2 independently from angiotensin II generation and induction of full enzymatic activity to initiate angiotensin II-dependent effects.
Yuji, Tani, Masayoshi, Shichiri
openaire   +1 more source

Laughter modulates prorenin receptor gene expression in patients with type 2 diabetes

Journal of Psychosomatic Research, 2007
Fumiaki Suzuki, Miyo Hori
exaly  

Prorenin has high affinity multiple binding sites for (pro)renin receptor

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2009
Atsuhiro Ichihara, Fumiaki Suzuki, A H M Nurun Nabi   +2 more
exaly  

Prorenin, its maturation and the (pro)renin receptor

2018
Expression of the mouse putative (pro)renin receptor (RR) was detected by RT-PCR in all tissues and cell lines examined including human mesangial cells previously reported to be negative for RR. Mouse RR was also present during development from E9.5. The mouse and rat RR cDNA were found to be highly homologous (92% and 91%, respectively) to the human ...
openaire   +1 more source

Renin- and Prorenin-Induced Effects in Rat Vascular Smooth Muscle Cells Overexpressing the Human (Pro)Renin Receptor

Hypertension, 2011
Xifeng Lu, Dominik N Müller, Wendy W Batenburg   +2 more
exaly