Results 171 to 180 of about 3,903,665 (206)

Prorenin receptor in kidney development

Pediatric Nephrology, 2016
Prorenin receptor (PRR), a receptor for renin and prorenin and an accessory subunit of the vacuolar proton pump H+-ATPase, is expressed in the developing kidney. Global loss of PRR is lethal in mice, and PRR mutations are associated with a high blood pressure, left ventricular hypertrophy and X-linked mental retardation in humans.
Ihor V. Yosypiv
openaire   +3 more sources

Nicotine Treatment Resulted in Decreased Protein Expression of Prorenin and Soluble Prorenin Receptor in 3T3‐L1 cells

The FASEB Journal, 2022
Over 36.5% of the United States population is affected by obesity, which is a major contributing factor to the rise of hypertension and cardiovascular disease.
Katelyn Collins, Kellea Nichols, Audrey Poupeau, A. Taylor, Frederique Yiannikouris   +4 more
semanticscholar   +1 more source

Deletion of Prorenin Receptor in the Rostral Ventrolateral Medulla Results in Biphasic and Sex‐Dependent Pressor Responses in Deoxycorticosterone Acetate‐salt Hypertension

The FASEB Journal, 2022
In models of low renin hypertension such as the deoxycorticosterone acetate (DOCA)‐salt model, the local generation of angiotensin II in the brain mediates the increase in blood pressure.
Pablo Nakagawa, Daniel T. Brozoski, N. Mathieu, Ko‐ting Lu, Javier A. Gomez, J. Reho, Shi Fang, Jeffrey L. Segar, Justin L. Grobe, Curt D. Sigmund   +9 more
semanticscholar   +1 more source

The placental prorenin/prorenin receptor system

Placenta, 2017
Samantha Rodrigues, Saije Morosin, Sarah Delforce, Riazuddin Mohammed, Eugenie Lumbers, Kirsty Pringle   +5 more
openaire   +2 more sources

Receptor-Associated Prorenin System in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma and Neovascular Glaucoma

Journal of Clinical Medicine, 2020
The receptor-associated prorenin system (RAPS) is associated with several pathologic conditions, including diabetic retinopathy, age-related macular degeneration, and uveitis.
Susumu Ishida, Atsuhiro Kanda
exaly   +2 more sources

Renin, Prorenin, and the (Pro)Renin Receptor

2009
The discovery of a receptor for renin and for its inactive precursor prorenin, and the introduction of renin inhibitors in therapeutic, has renewed the interest for the physiology of the renin angiotensin system (RAS) and has brought prorenin back in the spotlight.
Genevieve Nguyen, Aurelie Contrepas
openaire   +1 more source

Renin/prorenin-receptor biochemistry and functional significance

Current Hypertension Reports, 2004
The renin-angiotensin system (RAS) has become increasingly complex. New components have been identified, and additional roles for angiotensin peptides and their receptors are being uncovered. A functional (pro)renin receptor has been cloned that acts as (pro)renin cofactor on cell surface, enhancing the efficiency of angiotensinogen cleavage by (pro ...
Geneviève, Nguyen, Céline A, Burcklé, Jean-Daniel, Sraer   +2 more
openaire   +2 more sources

[The prorenin receptor].

Journal de la Societe de biologie, 2010
The renin-angiotensin system (RAS) is one of the most important systems in physiology and in pathology. The (pro)renin receptor [(P)RR] is a new component of the system that has attracted much attention, being potentially a new therapeutic target, because the binding of renin and of prorenin triggers the activation of the mitogen-activated protein ...
Diane, Bracquart, Christelle, Cousin, Aurélie, Contrepas, Geneviève, Nguyen   +3 more
openaire   +1 more source

Of Wnt, Prorenin Receptor, and V-ATPase

Science, 2010
A dual-function protein acts as an adaptor in a major developmental signaling pathway.
openaire   +2 more sources