Results 31 to 40 of about 78,509 (319)

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico, Becker, Wiebke, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Nusing, Rolf M., Popp, Laura, Schmidt, Ronald, Scholich, Klaus   +8 more
core   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S., Appel, Kurt, Bhatia, Harsharan S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Lieb, Klaus, Munoz, Eduardo   +7 more
core   +1 more source

Differential expression and regulation of cylooxygenases, prostaglandin E synthases and prostacyclin synthase in rat uterus during the peri-implantation period.

Reproduction, 2006
It has been shown that both prostaglandin I2 (PGI2) and PGE2 are essential for mouse implantation, whereas only PGE2 is required for hamster implantation. To date, the expression and regulation of cyclooxygenase (COX) and prostaglandin E synthase (PGES),
J. Cong, H. Diao, Yue-chao Zhao, H. Ni, Yunqin Yan, Zeng-Ming Yang   +5 more
semanticscholar   +1 more source

Regulation of Cytosolic Prostaglandin E Synthase [PDF]

Journal of Health Science, 2007
Biosynthesis of prostaglandin E2 (PGE2), the most common prostanoid with potent and various biological activities, is regulated by three sequential steps of cyclooxygenase (COX) pathway. We reported the molecular identification of cytosolic prostaglandin E synthase (cPGES), a terminal enzyme of the COX-mediated PGE2 biosynthetic pathway.
openaire   +2 more sources

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

BMC Genomics, 2010
Background Prostaglandin E2 (PGE2) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor α (TNFα)
Modéer Thomas, Lundeberg Joakim, Lindberg Johan, Båge Tove, Yucel-Lindberg Tülay   +4 more
doaj   +1 more source

Obesity-induced changes in lipid mediators persist after weight loss. [PDF]

, 2017
BackgroundObesity induces significant changes in lipid mediators, however, the extent to which these changes persist after weight loss has not been investigated.Subjects/methodsWe fed C57BL6 mice a high-fat diet to generate obesity and then switched the ...
Börgeson, E, Hernandez-Carretero, A, La Frano, MR, Lantero Rodriguez, J, Newman, JW, Osborn, O, Sears, DD, Wallenius, V, Weber, N, Ying, W   +9 more
core   +2 more sources

Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans. [PDF]

, 2014
BACKGROUND/OBJECTIVES: Obesity has been associated with both changes in adipose tissue lipid metabolism and inflammation. A key class of lipid-derived signalling molecules involved in inflammation are the prostaglandins.
A Gonzalez-Periz, A Neuhofer, A Pirraco, A Vidal-Puig, AD Dobrian, AG Oliveira, AL Hevener, B A M de Weijer, BA de Weijer, C Y L Mok, CW Miller, D Pal, D Patsouris, DA Casimir, DY Oh, E Bresson, E Ricciotti, FE Volat, G Vassaux, G Vassaux, H Ruan, H Shi, J Claria, J Eguchi, J L Griffin, JI Odegaard, JM Wentworth, K Jaworski, M Dale, M Eiden, M J Serlie, M Masoodi, M Masoodi, M Masoodi, M Sanchez-Alavez, M van Eijk, MJ Reginato, MS Han, NK Hopkins, P Chatterjee, P Flachs, P Strong, PO Hetu, PR Shepherd, RM Catalioto, S Lambert-Langlais, S Rajaram, S Virtue, S Virtue, SP Weisberg, SY Weng, T Deng, X Liao, X Prieur, Y Fujitani, Y Urade, Z Kabututu   +56 more
core   +4 more sources

Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells

Journal of Neuroinflammation, 2009
Resveratrol, a polyphenol present in grapes and red wine, has been studied due to its vast pharmacological activity. It has been demonstrated that resveratrol inhibits production of inflammatory mediators in different in vitro and in vivo models.
Candelario-Jalil Eduardo, Bhatia Harsharan S, de Oliveira Antonio, Wendeburg Lena, Fiebich Bernd L   +4 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source