Results 51 to 60 of about 78,509 (319)

Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market.
Paola Rizzarelli, Melania Leanza, Marco Rapisarda   +2 more
wiley   +1 more source

Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis [PDF]

Carcinogenesis, 2009
Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, and comparing with a gene signature
Carmen Z. Michaylira, Shinya Ohashi, Hiroshi Nakagawa, Yasuhiro Shirakawa, James J. Lee, Michiyuki Kanai, Yoshio Naomoto, Andres J. Klein-Szanto, Mitsuteru Natsuizaka, Gabrielle S. Wong, John W. Tobias, Volker H. Haase, Munenori Takaoka, Munenori Takaoka, Daniela Budo   +14 more
openaire   +3 more sources

The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders

Experimental Biology and Medicine, 2023
The cyclooxygenase (COX)/prostaglandin E2 (PGE2) signaling pathway has emerged as a critical target for anti-inflammatory therapeutic development in neurological diseases. However, medical use of COX inhibitors in the treatment of various neurological disorders has been limited due to well-documented cardiovascular and cerebrovascular complications. It
Madison N Sluter, Qianqian Li, Nelufar Yasmen, Yu Chen, Lexiao Li, Ruida Hou, Ying Yu, Chao-Yie Yang, Bernd Meibohm, Jianxiong Jiang   +9 more
openaire   +2 more sources

An Atomically Dispersed Photocatalyst for Undirected para‐Selective C─H Bond Functionalizations

Angewandte Chemie, EarlyView.
This study presents an atomically dispersed recyclable heterogeneous photocatalytic method for para‐selective trifluoromethylation of electron‐deficient arenes without directing groups. Unlike previous substrate‐dependent approaches, this recyclable, atomically dispersed photocatalyst enables scalable synthesis of bioactive trifluoromethylated ...
Suman Pradhan, Jun Hu, Peng Ren, Yuman Qin, Noopur Jain, Susanna Monti, Giovanni Barcaro, Aleksander Jaworski, Xingchao Dai, Jabor Rabeah, Joaquin Silvestre‐Albero, Veronica Celorrio, Anna Rokicińska, Piotr Kuśtrowski, Sandra Van Aert, Sara Bals, Shoubhik Das   +16 more
wiley   +2 more sources

COX-mediated endothelium-dependent contractions: From the past to recent discoveries [PDF]

, 2010
Endothelial cells release various substances to control the tone of the underlying vascular smooth muscle. Nitric oxide (NO) is the best defined endothelium-derived relaxing factor (EDRF).
Vanhoutte, PM, Wong, MSK
core   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study. [PDF]

, 1995
Homogenates of chick dorsal root ganglia (DRG) and in vitro cultures of DRG neurons are known to synthesize prostaglandin (PG) D2. To specify the PGD synthase isozymes controlling PGD2 synthesis in DRG and to identify the DRG cells responsible for this ...
Droz, B., Hayaishi, O., Urade, Y., Vesin, M.F.   +3 more
core   +1 more source

Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1

Scientific Reports, 2015
Prostacyclin synthase (PGIS) and microsomal prostaglandin E synthase-1 (mPGES-1) are prostaglandin (PG) terminal synthases that function downstream of inducible cyclooxygenase (COX)-2 in the PGI2 and PGE2 biosynthetic pathways, respectively.
Y. Sasaki, Shuhei Kamiyama, Azusa Kamiyama, K. Matsumoto, M. Akatsu, Yoshihito Nakatani, H. Kuwata, Y. Ishikawa, T. Ishii, C. Yokoyama, S. Hara   +10 more
semanticscholar   +1 more source

Engineered MSC Aggregates with E/N‐Cadherin and IL‐6 Preconditioning for the Treatment of Systemic Sclerosis

Advanced Healthcare Materials, EarlyView.
Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang, Mengyuan Qian, Yirui Shi, Jiaxu Cao, Min Xu, Xin Wen, Yunxia Yan, Sha Liu, Hongwei Chen, Shanshan Liu, Jun Yang, Lingyun Sun   +11 more
wiley   +1 more source

Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain [PDF]

, 2009
In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death.
Garthwaite, J., Hall, C.N., Keynes, R.G.
core   +3 more sources