Results 81 to 90 of about 78,509 (319)

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum [PDF]

, 2005
Prostaglandin E2 (PGE2), is a major prostanoid produced by the activity of cyclooxygenases (COX) in response to various physiological and pathological stimuli. PGE2 exerts its effects by activating four specific E-type prostanoid receptors (EP1, EP2, EP3
Akundi, Ravi S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Ridelis, Ingrid, Slawik, Helen, Waschbisch, Anne   +6 more
core  

15-deoxy-Δ12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

Journal of Lipid Research, 2006
Prostaglandin (PG) E2 (PGE2) plays a predominant role in promoting colorectal carcinogenesis. The biosynthesis of PGE2 is accomplished by conversion of the cyclooxygenase (COX) product PGH2 by several terminal prostaglandin E synthases (PGES).
Oliver Schroäder, Yulyana Yudina, Alan Sabirsh, Nadine Zahn, Jesper Z. Haeggstroäm, Juärgen Stein   +5 more
doaj  

Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target [PDF]

, 2013
The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2.
Leclerc, Patrick
core   +1 more source

Endothelial dysfunction and vascular disease [PDF]

, 2009
The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor (EDRF) is nitric oxide (NO).
Abeywardena, Aikawa, Ajayi, Alexopoulos, Alp, Anselm, Ardigo, Arehart, Argacha, Asano, Aubin, Aubin, Auch-Schwelk, Auch-Schwelk, Auch-Schwelk, Auch-Schwelk, August, Bachschmid, Barton, Basu, Bauersachs, Bechara, Behrendt, Belhassen, Bellamy, Bellien, Benndorf, Blanco-Rivero, Boban, Bode-Böger, Borg-Capra, Bos, Boulanger, Boulanger, Bouvet, Brandes, Briet, Bucala, Budhiraja, Bulckaen, Busse, Busse, Buzzard, Böger, Böger, Böhm, Cai, Camacho, Celermajer, Cernadas, Challah, Chambers, Chan, Chan, Chan, Charpie, Chauhan, Chen, Cheng, Chou, Chu, Cohen, Cohen, Coimbra, Cooke, Cosentino, Cosentino, Cox, Csiszar, Csiszar, Csiszar, Dantas, Dantas, Das, Davidge, Davidge, Davies, Davis, De Mey, De Mey, De Mey, De Vriese, DeLano, Dell’Agli, Derkach, Dhein, Dickson, Dimmeler, Dudzinski, Duffy, Duncan, Engler, Eringa, Eto, Feron, Ferreiro, Fichtlscherer, Filipe, Filser, Fisher, Fisslthaler, Flammer, Flavahan, Flavahan, Fleming, Fleming, Focardi, Fournet-Bourguignon, Frank, Fresquet, Furchgott, Furchgott, Furchgott, Furuhashi, Furuhashi, Félétou, Félétou, Félétou, Félétou, Félétou, Förstermann, Gamboa, Ganz, Gao, Garcia-Cohen, Ge, Ge, Gertz, Gill, Gisclard, Gluais, Gluais, Gluais, Goel, Gollasch, Graier, Grassi, Grisk, Gryglewski, Guns, Guzik, Halcox, Hambrecht, Han, Hanratty, Hansson, Hashikabe, Hattori, Heeba, Heiss, Herrmann, Heymes, Hibbert, Hirao, Hodgson, Holowatz, Hongo, Hoo, Houston, Houston, Hristovska, Husain, Hutri-Kahonen, Iellamo, Ignarro, Ignarro, Ignarro, Ijzerman, Ikeda, Indik, Inkster, Inoue, Iqbal, Ito, Iwama, Iwatani, Jankowski, Kagota, Kaiser, Kajiya, Kanani, Karagiannis, Kato, Katusic, Katusic, Katusic, Katusic, Katusic, Katz, Kaul, Kauser, Kennedy, Keung, Kim, Kim, Kirkby, Klöß, Knight, Koga, Koga, Kojda, Kubo, Kung, Kuriyama, Kuvin, Kähönen, Lamping, Landmesser, Landmesser, Landmesser, Lang, Lang, Lauer, Lavi, Lee, Lee, Lefèvre, Leikert, Lembo, Lesniewski, Leung, Levine, Levy, Li, Li, Li, Li, Li, Lida, Lin, Liu, Lockette, Looft-Wilson, Lopez-Sepulveda, Lu, Ludmer, Luz, Lyons, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Macarthur, Machha, Machha, Maejima, Malo, Mancini, Marletta, Matoba, Matsumoto, Mayhan, Mayhan, Meyer, Michaud, Michel, Michel, Michel, Miller, Miller, Miller, Miller, Ming, Mitchell, Miyagawa, Moat, Mombouli, Mombouli, Mombouli, Mombouli, Moncada, Monobe, Monsalve, Montalcini, Morikawa, Moritoki, Motley, Mundy, Nagata, Nakamura, Nassar, Naya, Nietlispach, Nigris, Nigris, Nigris, Norel, Numaguchi, Obrosova, Okano, Okon, Ospina, O’Rourke, Pacher, Palm, Palmer, Palmer, Palmer, Palmer, Pannirselvam, Paulis, Pearson, Pellegrini, Perticone, Pierce, Quijano, Radomski, Rakobowchuk, Rapoport, Romero, Ross, Rossi, Roves, Rubanyi, Rubanyi, Rubanyi, Rubanyi, Rubanyi, Ryoo, Ryoo, Saifeddine, Santhanam, Santos, Sarr, Sartorio, Sata, Sbarouni, Schini, Schini, Schini, Schini-Kerth, Schroeter, Schäfer, Scott, Sekikawa, Sena, Shepherd, Shi, Shi, Shi, Shi, Shi, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shirahase, Silva, Skott, Smith, Soares de Moura, Sousa, Spier, Spooner, Steinberg, Stepp, Stocker, Stocker, Stockley, Stuehr, Stähli, Subramanian, Sun, Suvorava, Suwaidi, Taddei, Taddei, Taddei, Taddei, Taddei, Taddei, Taddei, Tan, Tang, Tang, Tang, Tang, Tang, Tang, Taubert, Tesfamariam, Tesfamariam, Tesfamariam, Tesfamariam, Tostes, Touyz, Touyz, Traupe, Traupe, Treasure, Trochu, Tschudi, Tschudi, Uhrenholt, Uhrenholt, Ungvari, Vallance, Vallejo, Van Guilder, Van Guilder, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Voetsch, von Schacky, Wallerath, Wang, Wang, Wassmann, Watts, Widder, Wilson, Wong, Wong, Xiang, Xiong, Xu, Xu, Yan, Yanagisawa, Yanagisawa, Yang, Yang, Yasuro, Yin, Zampetaki, Zerrouk, Zhang, Zhao, Zhong, Zhou, Zhou, Zhu, Zou, Zou, Álvarez, Álvarez   +460 more
core   +1 more source

Structured Lipids: Synthesis, Genetic Engineering, and Applications

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Lipids are essential to the human body, but some can be harmful. As a result, current research focuses on structured lipids (SLs), which are engineered to have specific fatty acid arrangements. These structural modifications can enhance both nutritional and physical properties.
Chandu S. Madankar, Avishkar S. Bhagat, Elham K. Nasser, Ammar B. Altemimi, Francesco Cacciola, Nasser Mahna   +5 more
wiley   +1 more source

Quantitative structure–activity relationship based modeling of substituted indole Schiff bases as inhibitor of COX-2 [PDF]

, 2013
We have performed the quantitative structure activity relationship (QSAR) study for N-1 and C-3 substituted indole shiff bases to understand the structural features that influence the inhibitory activity toward the cyclooxygenase-2 (COX-2) enzyme.
Dwivedi, Amrita, Singh, Ajeet, Srivastava, A.K.   +2 more
core   +2 more sources

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng, Qi Zhang, Xinxin Tang, Fan Ying, Dawei Liu, Sen Li, Ranran Liu, Jie Wen, QingHe Li, Guiping Zhao   +9 more
wiley   +1 more source

Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation

Arthritis &Rheumatology, EarlyView.
Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source