Results 111 to 120 of about 4,092 (168)

Prostaglandin endoperoxide synthase isozymes

1997
Abstract PGH synthases catalyze the initial reaction common to the formation of prostanoids and are the target sites for most nonsteroidal anti-inflammatory drugs (NSAIDs). Until the recent discovery of a second PGH synthase isozyme (PGH synthase-2; PGHS-2), it was thought that NSAIDs acted by inhibiting a single enzyme, now referred to as PGH ...
William L. Smith, David L. DeWitt
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Prostaglandin Endoperoxide H Synthases-1 and -2

1996
Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of the interactions of the two isozymes with nonsteroidal anti-inflammatory drugs (NSAIDs). There are three general areas of study important to understanding more about
W L, Smith, D L, Dewitt
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Mechanism of Hydroperoxide Reduction by Mangano-Prostaglandin Endoperoxide Synthase

Biochemistry, 1996
Reaction of manganese-reconstituted prostaglandin endoperoxide synthase (Mn-PGHS) with 15-hydroperoxyeicosatetraenoic acid (15-HPETE) generates two products in nearly equal amounts: 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-ketoeicosatetraenoic acid (15-KETE) [Kulmacz et al. (1994) Biochemistry 33, 5428-5439]. Their proposed mechanism to explain
L M, Landino, L J, Marnett
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Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases

European Journal of Pharmacology, 1996
The aim of our study was to evaluate the selectivity of flurbiprofen and flurbinitroxybutylester for inhibition of the cyclooxygenase activity of prostaglandin endoperoxide synthase-2 vs. prostaglandin endoperoxide synthase-1 in human blood monocytes and platelets, respectively.
Santini, G, Sciulli, Mg, Panara, Mr, Padovano, R, di Giamberardino, M, Rotondo, Mt, Del Soldato, P, PATRIGNANI, Paola   +7 more
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The enzymology of prostaglandin endoperoxide H synthases-1 and -2

Prostaglandins & Other Lipid Mediators, 2002
We summarize the enzymological properties of prostaglandin endoperoxide H synthases (PGHs)-1 and -2, the enzymes that catalyze the committed step in prostaglandin biosynthesis. These isoenzymes are closely related structurally and mechanistically.
William L, Smith, Inseok, Song
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Activation of 2-Aminofluorene by Prostaglandin Endoperoxide H Synthase 2

Biochemical and Biophysical Research Communications, 1995
Prostaglandin endoperoxide H synthase is the key enzyme in the conversion of arachidonic acid to tissue prostanoids. Two isoforms of prostaglandin endoperoxide H synthase have been identified: PHS-1 is constitutively expressed in most tissues under normal physiological conditions and PHS-2 is expressed in response to inflammatory agents, tumor ...
Y, Liu, G N, Levy, W W, Weber
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Immunocytochemical localization of prostaglandin endoperoxide synthase in the bovine intestine

Histochemistry, 1993
The localization of prostaglandin (PG) endoperoxide synthase in bovine intestine was examined immunocytochemically with polyclonal antibody raised against PG endoperoxide synthase purified from bovine seminal glands. The most intense positive staining reaction for the enzyme was present in mast cells.
K, Ishimura, T, Suzuki, K, Fukui, A, Yamamoto, Y, Omoto, N, Ueda, S, Yamamoto   +6 more
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Prostaglandin endoperoxide H synthase expression in human thyroid epithelial cells

American Journal of Physiology-Cell Physiology, 2001
KAT-50, an established human thyrocyte cell line, expresses constitutively high levels of prostaglandin endoperoxide H synthase-2 (PGHS-2), the inflammatory cyclooxygenase. Here, we examine primary human thyrocytes. We find that they, too, express PGHS-2 mRNA and protein under control culture conditions.
A G, Gianoukakis, H J, Cao, T A, Jennings, T J, Smith   +3 more
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Not prostacyclin synthase but prostaglandin endoperoxide synthase increases with human placental development

Prostaglandins, 1986
Prostaglandin endoperoxide synthase (i.e. cyclooxygenase; PGH synthase) and prostacyclin synthase (PGI synthase) were quantitated with specific immunoradiometric assays in microsomes from human placentae (n = 20) obtained from 7 up to 17 weeks of gestation.
M J, Keirse, J J, Erwich, G, Klok
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Characterization of a Tyrosyl Radical in Prostaglandin Endoperoxide Synthase-2

Biochemical and Biophysical Research Communications, 1994
Two different isoforms of prostaglandin H synthase, prostaglandin H synthase-1 and prostaglandin H synthase-2, have been identified. Both isozymes catalyze both cyclooxygenase and peroxidase reactions. Residues identified as being essential for catalysis by ovine prostaglandin endoperoxide H synthase-1 are all conserved in prostaglandin H synthase-2 ...
L C, Hsi, C W, Hoganson, G T, Babcock, W L, Smith   +3 more
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