Results 121 to 130 of about 4,092 (168)

Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids

Biochemical and Biophysical Research Communications, 1991
C22:1 omega 5-anacardic acid was found to be a good inhibitor of both potato lipoxygenase and ovine prostaglandin endoperoxide synthase with approximate IC50's of 6 and 27 microM, respectively. Very similar inhibition was seen with the crude exudate, rich in omega 5-anacardic acids, from glandular trichomes of an arthropod-resistant strain of geranium,
R, Grazzini, D, Hesk, E, Heininger, G, Hildenbrandt, C C, Reddy, D, Cox-Foster, J, Medford, R, Craig, R O, Mumma   +8 more
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Rapid Inactivation of Prostaglandin Endoperoxide Synthases by N-(Carboxyalkyl)maleimides

Biochemistry, 1994
N-(Carboxyalkyl)maleimides were synthesized as potential inhibitors of prostaglandin endoperoxide synthase (PGHS). Inactivation of the cyclooxygenase and peroxidase activities of PGHS occurred in a biphasic manner with extremely rapid inactivation followed by slow, time-dependent inactivation.
A S, Kalgutkar, L J, Marnett
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Expression of prostaglandin endoperoxide synthase-1 in a baculovirus system

Biochemical and Biophysical Research Communications, 1992
A cDNA coding for ovine prostaglandin endoperoxide (PGH) synthase-1 was used to construct a recombinant baculovirus which was expressed in Spodoptera frugiperda (Sf9) insect cells. Two proteins reactive with anti-PGH synthase antibody were produced. A larger protein (Mr = 72,000) coelectrophoresed with native enzyme; a smaller, more abundant protein ...
T, Shimokawa, W L, Smith
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Conversions of prostaglandin endoperoxides by prostacyclin synthase from pig aorta

Prostaglandins, 1980
Partially purified prostacyclin synthase from pig aorta converted the prostaglandin (PG) endoperoxide PGH2 to prostacyclin (PGI2), and PGH1 to 12-hydroxy-8,10-heptadecadienoic acid (HHD). Both reactions were inhibited by 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HP) in a dose-dependent rashion.
P, Wlodawer, S, Hammarström
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Characterization of prostaglandin endoperoxide synthase from a human cell line

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
Prostaglandin endoperoxide synthase has been purified from the recently established human lung tumor cell line, Lu-65. By gel filtration, the purified enzyme migrated with a relative molecular weight of 115,000, unlike the ovine enzyme, which migrated at 155,000.
N J, Hickok, G, Chin, R S, Bockman
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Characterization of a novel prostaglandin endoperoxide H synthase-1 transcript and examination of prostaglandin endoperoxide H synthase-1 expression.

2009
The prostaglandin endoperoxide H synthase (PGHS) enzyme plays a pivotal role in the prostanoid biosynthetic pathway because it catalyzes the formation of prostaglandin H2 (PGH2), the common precursor for prostanoids. The object of my research is to characterize a novel PGHS transcript and to examine the mechanisms that regulate PGHS-1 gene expression ...
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Inactivation of Prostaglandin Endoperoxide Synthase (PGHS) by N-(Substituted)Maleimides

1997
Prostaglandin endoperoxide synthase (PGHS, EC 1.14.99.1) catalyzes the first two steps of prostaglandin biosynthesis.1 Its cyclooxygenase activity oxygenates arachidonic acid to form PGG2; the peroxidase activity of the enzyme then reduces PGG2 in the presence of a reducing substrate to the corresponding alcohol PGH2.2,3 The cyclooxygenase activity is ...
A S, Kalgutkar, B C, Crews, L J, Marnett
openaire   +2 more sources

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Prostaglandin Endoperoxide Synthases

2010
Melissa V. Turman, Lawrence J. Marnett
openaire   +1 more source

Prostaglandin-endoperoxide synthase

1994
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source