Results 141 to 150 of about 4,137 (180)
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Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids
Biochemical and Biophysical Research Communications, 1991C22:1 omega 5-anacardic acid was found to be a good inhibitor of both potato lipoxygenase and ovine prostaglandin endoperoxide synthase with approximate IC50's of 6 and 27 microM, respectively. Very similar inhibition was seen with the crude exudate, rich in omega 5-anacardic acids, from glandular trichomes of an arthropod-resistant strain of geranium,
R, Grazzini +8 more
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Characterization of a Tyrosyl Radical in Prostaglandin Endoperoxide Synthase-2
Biochemical and Biophysical Research Communications, 1994Two different isoforms of prostaglandin H synthase, prostaglandin H synthase-1 and prostaglandin H synthase-2, have been identified. Both isozymes catalyze both cyclooxygenase and peroxidase reactions. Residues identified as being essential for catalysis by ovine prostaglandin endoperoxide H synthase-1 are all conserved in prostaglandin H synthase-2 ...
L C, Hsi +3 more
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Expression of prostaglandin endoperoxide synthase-1 in a baculovirus system
Biochemical and Biophysical Research Communications, 1992A cDNA coding for ovine prostaglandin endoperoxide (PGH) synthase-1 was used to construct a recombinant baculovirus which was expressed in Spodoptera frugiperda (Sf9) insect cells. Two proteins reactive with anti-PGH synthase antibody were produced. A larger protein (Mr = 72,000) coelectrophoresed with native enzyme; a smaller, more abundant protein ...
T, Shimokawa, W L, Smith
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Localization of prostaglandin endoperoxide synthase in the human corpus luteum
Human Reproduction, 1990Prostaglandins have been implicated in both maintenance and luteolysis of the primate corpus luteum. Central to the production of prostaglandins is the enzyme prostaglandin endoperoxide synthase (PGHS). In the present study, we identified the cell types which contain PGHS in 44 human corpora lutea, using immunoperoxidase staining techniques.
S W, Kauma +3 more
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BJOG: An International Journal of Obstetrics & Gynaecology, 1986
Summary. Prostacyclin (PGI2) synthase and prostaglandin endoperoxide synthase (cyclo‐oxygenase; PGH synthase) were measured with specific immunoradiometric assays in myometrial microsomes from different areas of a primigravid uterus at 34 weeks gestation. PGH synthase concentrations increased significantly from fundus toward lower segment (P <0·005)
P, Moonen, G, Klok, M J, Keirse
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Summary. Prostacyclin (PGI2) synthase and prostaglandin endoperoxide synthase (cyclo‐oxygenase; PGH synthase) were measured with specific immunoradiometric assays in myometrial microsomes from different areas of a primigravid uterus at 34 weeks gestation. PGH synthase concentrations increased significantly from fundus toward lower segment (P <0·005)
P, Moonen, G, Klok, M J, Keirse
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Prostaglandins, 1986
Prostaglandin endoperoxide synthase (i.e. cyclooxygenase; PGH synthase) and prostacyclin synthase (PGI synthase) were quantitated with specific immunoradiometric assays in microsomes from human placentae (n = 20) obtained from 7 up to 17 weeks of gestation.
M J, Keirse, J J, Erwich, G, Klok
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Prostaglandin endoperoxide synthase (i.e. cyclooxygenase; PGH synthase) and prostacyclin synthase (PGI synthase) were quantitated with specific immunoradiometric assays in microsomes from human placentae (n = 20) obtained from 7 up to 17 weeks of gestation.
M J, Keirse, J J, Erwich, G, Klok
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Prostaglandin endoperoxide synthase: why two isoforms?
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1996Prostaglandin endoperoxide synthase-1 [prostaglandin G/H synthase-1 (PGHS-1)] and PGHS-2 are key enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids. We refer to these isoforms as cyclooxygenase-1 (COX-1) and COX-2 in this review.
C S, Williams, R N, DuBois
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Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase
Prostaglandins, 1978We have investigated the time course of formation of thromboxane A2, thromboxane B2, and the C-17 hydroxy fatty acid, HHT, from arachidonic acid in a washed human platelet suspension. Our results indicate that HHT is not a breakdown product of thromboxane A2, but rather thromboxane A2 decomposes exclusively into thromboxane B2.
M W, Anderson +3 more
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Activation of 2-Aminofluorene by Prostaglandin Endoperoxide H Synthase 2
Biochemical and Biophysical Research Communications, 1995Prostaglandin endoperoxide H synthase is the key enzyme in the conversion of arachidonic acid to tissue prostanoids. Two isoforms of prostaglandin endoperoxide H synthase have been identified: PHS-1 is constitutively expressed in most tissues under normal physiological conditions and PHS-2 is expressed in response to inflammatory agents, tumor ...
Y, Liu, G N, Levy, W W, Weber
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2009
The prostaglandin endoperoxide H synthase (PGHS) enzyme plays a pivotal role in the prostanoid biosynthetic pathway because it catalyzes the formation of prostaglandin H2 (PGH2), the common precursor for prostanoids. The object of my research is to characterize a novel PGHS transcript and to examine the mechanisms that regulate PGHS-1 gene expression ...
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The prostaglandin endoperoxide H synthase (PGHS) enzyme plays a pivotal role in the prostanoid biosynthetic pathway because it catalyzes the formation of prostaglandin H2 (PGH2), the common precursor for prostanoids. The object of my research is to characterize a novel PGHS transcript and to examine the mechanisms that regulate PGHS-1 gene expression ...
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