Results 131 to 140 of about 2,860 (168)
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Biochemical and Biophysical Research Communications, 1994
A Prostaglandin endoperoxide synthase isoenzyme was recently identified in several cell lines. Osteoblasts possess Prostaglandin endoperoxide synthase activity, but it is not known which isoenzymes are present in these cells. Our objective was to identify these isoenzymes in human osteoblasts. Resting cells in culture did not produce measurable amounts
Patry C +7 more
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A Prostaglandin endoperoxide synthase isoenzyme was recently identified in several cell lines. Osteoblasts possess Prostaglandin endoperoxide synthase activity, but it is not known which isoenzymes are present in these cells. Our objective was to identify these isoenzymes in human osteoblasts. Resting cells in culture did not produce measurable amounts
Patry C +7 more
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Prostaglandin endoperoxide synthase: structure and catalysis
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991In this review, we describe the properties of PGH synthase, the enzyme which catalyzes the committed step in the synthesis of prostaglandins and thromboxane. We begin by presenting an overview of protanoid biosynthesis and the mechanism of action of these local hormones. We then describe the novel characteristics of the two distinct reactions catalyzed
William L. Smith, Lawrence J. Marnett
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Prostaglandin endoperoxide synthases-1 and -2
Journal of Lipid Mediators and Cell Signalling, 1995Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of the interactions of the two isozymes with nonsteroidal anti-inflammatory drugs (NSAIDs).
James C. Otto, William L. Smith
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Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases
European Journal of Pharmacology, 1996The aim of our study was to evaluate the selectivity of flurbiprofen and flurbinitroxybutylester for inhibition of the cyclooxygenase activity of prostaglandin endoperoxide synthase-2 vs. prostaglandin endoperoxide synthase-1 in human blood monocytes and platelets, respectively.
Santini, G +7 more
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Expression of prostaglandin endoperoxide synthase in rat brain
Molecular Brain Research, 1993Developmental and regional expression of prostaglandin endoperoxide synthase (PES) transcript was examined in the rat brain and in primary mixed cultures of neurons and glial cells from neonatal brain. Although the PES mRNA level in the brain was much lower than that in peripheral rat tissues such as lung, liver, spleen and kidney, a significant 3.0 kb
Mie Yamaji +3 more
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Prostaglandin endoperoxide synthase: why two isoforms?
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1996Prostaglandin endoperoxide synthase-1 [prostaglandin G/H synthase-1 (PGHS-1)] and PGHS-2 are key enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids. We refer to these isoforms as cyclooxygenase-1 (COX-1) and COX-2 in this review.
Raymond N. DuBois +1 more
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The enzymology of prostaglandin endoperoxide H synthases-1 and -2
Prostaglandins & Other Lipid Mediators, 2002We summarize the enzymological properties of prostaglandin endoperoxide H synthases (PGHs)-1 and -2, the enzymes that catalyze the committed step in prostaglandin biosynthesis. These isoenzymes are closely related structurally and mechanistically.
In-Seok Song, William L. Smith
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Prostaglandin Endoperoxide H Synthases-1 and -2
1996Publisher Summary The chapter compares and contrasts the structural and kinetic properties of prostaglandin endoperoxide H synthase-1 (PGHS-1) and -2. It also discusses the description of the interactions of the two isozymes with nonsteroidal anti-inflammatory drugs (NSAIDs). There are three general areas of study important to understanding more about
William L. Smith, David L. DeWitt
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Characterization of a Tyrosyl Radical in Prostaglandin Endoperoxide Synthase-2
Biochemical and Biophysical Research Communications, 1994Two different isoforms of prostaglandin H synthase, prostaglandin H synthase-1 and prostaglandin H synthase-2, have been identified. Both isozymes catalyze both cyclooxygenase and peroxidase reactions. Residues identified as being essential for catalysis by ovine prostaglandin endoperoxide H synthase-1 are all conserved in prostaglandin H synthase-2 ...
Gerald T. Babcock +3 more
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Mechanism of Hydroperoxide Reduction by Mangano-Prostaglandin Endoperoxide Synthase
Biochemistry, 1996Reaction of manganese-reconstituted prostaglandin endoperoxide synthase (Mn-PGHS) with 15-hydroperoxyeicosatetraenoic acid (15-HPETE) generates two products in nearly equal amounts: 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-ketoeicosatetraenoic acid (15-KETE) [Kulmacz et al. (1994) Biochemistry 33, 5428-5439]. Their proposed mechanism to explain
Lisa M. Landino, Lawrence J. Marnett
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