Results 21 to 30 of about 17,612 (262)
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2011 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Nicolaou, A +3 more
core +7 more sources
Selective COX-2 inhibitors and risk of myocardial infarction [PDF]
, 2005 Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V. +3 more
core +1 more source
Nitro-fatty acids: novel anti-inflammatory lipid mediators
Brazilian Journal of Medical and Biological Research, 2013 Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways.
H. Rubbo
doaj +1 more source
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]
, 2006 Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S. +7 more
core +1 more source
Vasoconstrictor prostanoids [PDF]
, 2010 In cardiovascular diseases and during aging, endothelial dysfunction is due in part to the release of endothelium-derived contracting factors that counteract the vasodilator effect of the nitric oxide.
Félétou, M, Huang, Y, Vanhoutte, PM
core +1 more source
Topography of the Prostaglandin Endoperoxide H2 Synthase-2 in Membranes [PDF]
Journal of Biological Chemistry, 2006 The topology of association of the monotopic protein cyclooxygenase-2 (COX-2) with membranes has been examined using EPR spectroscopy of spin-labeled recombinant human COX-2. Twenty-four mutants, each containing a single free cysteine substituted for an amino acid in the COX-2 membrane binding domain were expressed using the baculovirus system and ...
Zahra MirAfzali +3 more
openaire +2 more sources
Frontiers in Neurology, 2017 Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the ...
Rosa Calvello +10 more
doaj +1 more source
ATP synthase: evolution, energetics, and membrane interactions [PDF]
J Gen Physiol. 2020 Nov 2;152(11):e201912475, 2020 The synthesis of ATP, life's 'universal energy currency', is the most prevalent chemical reaction in biological systems, and is responsible for fueling nearly all cellular processes, from nerve impulse propagation to DNA synthesis. ATP synthases, the family of enzymes that carry out this endless task, are nearly as ubiquitous as the energy-laden ...
arxiv +1 more source
Analysis of Sex-Specific Prostanoid Production Using a Mouse Model of Selective Cyclooxygenase-2 Inhibition [PDF]
, 2022 Background: Prostanoids are a family of lipid mediators formed from arachidonic acid by cyclooxygenase enzymes and serve as biomarkers of vascular function. Prostanoid production may be different in males and females indicating that different therapeutic
Becker, Wendy L +6 more
core +2 more sources
Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets. [PDF]
Proceedings of the National Academy of Sciences, 1977 Thromboxane synthase was localized to the microsomes of human platelets. The enzyme was insensitive to sulfhydryl reagents and thiols but was inhibited by 12L-hydroperoxy-5, 8, 10, 14-eicosatetraenoic acid (concentration for 50% inhibition = 0.1 mM).
Sven Hammarström, Pierre Falardeau
openaire +2 more sources