Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE 2 in colorectal cancer [PDF]
, 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Background]: Misregulation of the PTGS (prostaglandin endoperoxide synthase, also known as cyclooxygenase or COX) pathway may lead to the ...
Cebola, Inês +10 more
core +5 more sources
Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts [PDF]
, 2010 Background: Prostaglandin E-2 (PGE(2)) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth.
Tove Båge +4 more
core +1 more source
Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]
, 2020 Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar +10 more
core +1 more source
PharmaceuticalsXiaochaihu granules (XCHG) are extensively used to treat fever. Nevertheless, the underlying mechanism remains elusive. This study aimed to explore the potential of XCHG in mitigating yeast-induced fever and the underlying metabolic pathways.
Xiuli Chen +10 more
doaj +1 more source
Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study. [PDF]
, 1995 Homogenates of chick dorsal root ganglia (DRG) and in vitro cultures of DRG neurons are known to synthesize prostaglandin (PG) D2. To specify the PGD synthase isozymes controlling PGD2 synthesis in DRG and to identify the DRG cells responsible for this ...
Droz, B. +3 more
core +1 more source
Prostaglandin endoperoxide synthase contains an EGF‐like domain [PDF]
FEBS Letters, 1989 Prostaglandin endoperoxide synthase was subjected to the computer‐assisted homology search in the protein primary structure database, in order to investigate the regulation mechanism of the expression of prostaglandin endoperoxide synthase. As a result of that, it turned out that prostaglandin endoperoxide synthase shares sequence homology with ...
openaire +2 more sources
Topography of the Prostaglandin Endoperoxide H2 Synthase-2 in Membranes [PDF]
Journal of Biological Chemistry, 2006 The topology of association of the monotopic protein cyclooxygenase-2 (COX-2) with membranes has been examined using EPR spectroscopy of spin-labeled recombinant human COX-2. Twenty-four mutants, each containing a single free cysteine substituted for an amino acid in the COX-2 membrane binding domain were expressed using the baculovirus system and ...
Zahra, MirAfzali +3 more
openaire +2 more sources
In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]
, 2010 The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg +5 more
core +5 more sources
Expression of selected genes related to energy mobilization and insulin resistance in dairy cows [PDF]
, 2017 The physiological and metabolic adaptation characterizing the transition period in the dairy cows is developed by a complex modulation of different metabolic pathways as well as the expression of selected tissue-specific gene.
Arfuso, Francesca +6 more
core +1 more source
The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. [PDF]
, 2008 Decreased expression of peroxisome proliferator activated receptor-gamma (PPARgamma) and high levels of the proinflammatory enzyme cyclooxygenase-2 (COX-2) have been observed in many tumor types.
Dubinett, Steven M +4 more
core