Results 21 to 30 of about 15,910 (222)
Andrologia, Volume 54, Issue 11, December 2022., 2022 Abstract Varicocele (VC) is a common urogenital disease that leads to a high risk of testicular pain or male infertility. The purpose of this research was to explore the molecular mechanism of the Gui Zhi Fu Ling Wan (GFW) in the treatment of VC. The main active ingredients and targets information of GFW were screened by Traditional Chinese Medicine ...
Ruipeng Wang, Xiaoye Qiao, Xiaobin Wang
wiley +1 more source
Folia Morphologica, 2013 The aim of this study was to evaluate the occurrence and the activity of prostaglandin-endoperoxide synthase 1 (PTGS1), PTGS2, and endothelial, neuronal, and inducible nitric oxide synthase (e-, n-, and iNOS) in early, mid, late, and regressive corpora ...
M. Zerani +3 more
semanticscholar +1 more source
Nitro-fatty acids: novel anti-inflammatory lipid mediators
Brazilian Journal of Medical and Biological Research, 2013 Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways.
H. Rubbo
doaj +1 more source
Topography of the Prostaglandin Endoperoxide H2 Synthase-2 in Membranes [PDF]
Journal of Biological Chemistry, 2006 The topology of association of the monotopic protein cyclooxygenase-2 (COX-2) with membranes has been examined using EPR spectroscopy of spin-labeled recombinant human COX-2. Twenty-four mutants, each containing a single free cysteine substituted for an amino acid in the COX-2 membrane binding domain were expressed using the baculovirus system and ...
Zahra MirAfzali +3 more
openaire +2 more sources
Frontiers in Neurology, 2017 Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the ...
Rosa Calvello +10 more
doaj +1 more source
British Journal of Pharmacology, 1995 1 We have evaluated the selectivity of ketoprofen and two novel nonsteroidal anti‐inflammatory drugs, N‐[2‐(cyclohexyloxy)‐4‐nitrophenyl]methanesulphonamide (NS‐398) and 5‐methanesulphonamido‐6‐(2, 4‐difluorothiophenyl)‐1‐indanone (L‐745, 337), in ...
M. R. Panara +10 more
semanticscholar +1 more source
ATP synthase: evolution, energetics, and membrane interactions [PDF]
J Gen Physiol. 2020 Nov 2;152(11):e201912475, 2020 The synthesis of ATP, life's 'universal energy currency', is the most prevalent chemical reaction in biological systems, and is responsible for fueling nearly all cellular processes, from nerve impulse propagation to DNA synthesis. ATP synthases, the family of enzymes that carry out this endless task, are nearly as ubiquitous as the energy-laden ...
arxiv +1 more source
Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets. [PDF]
Proceedings of the National Academy of Sciences, 1977 Thromboxane synthase was localized to the microsomes of human platelets. The enzyme was insensitive to sulfhydryl reagents and thiols but was inhibited by 12L-hydroperoxy-5, 8, 10, 14-eicosatetraenoic acid (concentration for 50% inhibition = 0.1 mM).
Sven Hammarström, Pierre Falardeau
openaire +2 more sources
The Membrane Association Sequences of the Prostaglandin Endoperoxide Synthases-1 and -2 Isozymes*
Journal of Biological Chemistry, 1998 Based on the crystal structures of the prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and PGHS-2), four short amphipathic helices near the amino termini of these proteins have been proposed to act as membrane binding domains.
Yi Li, T. Smith, S. Grabski, D. Dewitt
semanticscholar +1 more source
Reproduction, 2009 To determine if changes in endometrial expression of the enzymes and receptors involved in prostaglandin (PG) synthesis and action might provide insights into the PGs involved in the initiation of decidualization, ovariectomized steroid-treated rats at ...
C. Gillio-Meina +4 more
semanticscholar +1 more source