Results 21 to 30 of about 4,678 (214)

Phorbol ester TPA modulates chemoresistance in the drug sensitive breast cancer cell line MCF-7 by inducing expression of drug efflux transporter ABCG2 [PDF]

, 2012
Recent studies have indicated a link between levels of cyclooxygenase-2 (COX-2) and development of the multidrug resistance (MDR) phenotype. The ATP-binding cassette sub-family G member 2 (ABCG2) is a major MDR-related transporter protein that is ...
Behravan, J., Elahian, F., Hassani, M., Kalalinia, F., Kasaeeian, J.   +4 more
core   +1 more source

Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]

, 2014
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F, Mauro, C, Nicolaou, A, Urquhart, P   +3 more
core   +3 more sources

Cyclooxygenase and prostaglandins in somatic cell populations of the testis [PDF]

, 2015
rostaglandins (PGs) are synthesized through the action of the rate-limiting enzyme cyclooxygenase (COX) and further specific enzymes. The development of Cox-deficient mice in the 1990s gave insights into the reproductive roles of PGs. Female Cox-knockout
Calandra, Ricardo Saul, Frungieri, Monica Beatriz, Matzkin, Maria Eugenia, Mayerhofer, Artur   +3 more
core   +1 more source

Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE 2 in colorectal cancer [PDF]

, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Background]: Misregulation of the PTGS (prostaglandin endoperoxide synthase, also known as cyclooxygenase or COX) pathway may lead to the ...
Cebola, Inês, Custodio Rojo, Joaquín, Muñoz, Mar, Díez-Villanueva, Anna, Paré, Laia, Prieto, Patricia, Aussó, Susanna, Coll-Mulet, Llorenç, Boscá, Lisardo, Moreno Aguado, Víctor, Peinado Morales, Miguel Á. (Miguel Ángel)   +10 more
core   +5 more sources

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism [PDF]

, 2018
Trypanosomatid parasites are the infectious agents causing Chagas’ disease, visceral and cutaneous leishmaniasis and human African trypanosomiasis. Recent work of others has implicated an aldo-keto reductase (AKR) in susceptibility and resistance of ...
Adam J. Roberts, Akita, Alan H. Fairlamb, Andrade, Ashton, Bahia, Catisti, Chakraborty, Copeland, Davies, Eperon, Fairlamb, Feasey, Fersht, Garavaglia, Garavaglia, Goyard, Greig, Güther, Hall, Hall, Hamberg, Hunter, Inoue, Jamdhade, Jez, Joanne Dunne, Kabututu, Kabututu, Kaiser, Kasai, Kilunga, Kubata, Kubata, Li, Livore, Mauël, Milne, Milne, Moen, Morrow, Morrow, Morrow, Murata, Murta, Opperdoes, Panicucci, Patterson, Paul Scullion, Rabbani, Rath, Ridgley, Roberts, Roberts, Sokolova, Stuart, Studier, Suzanne Norval, Thornalley, Toledo, Trochine, Trochine, Turrens, Ujihara, Uttaro, Wermuth, Wilkinson, Wyllie, Wyllie, Wyllie, Xu, Young   +71 more
core   +2 more sources

Unraveling the Mechanism of Xiaochaihu Granules in Alleviating Yeast-Induced Fever Based on Network Analysis and Experimental Validation

Pharmaceuticals
Xiaochaihu granules (XCHG) are extensively used to treat fever. Nevertheless, the underlying mechanism remains elusive. This study aimed to explore the potential of XCHG in mitigating yeast-induced fever and the underlying metabolic pathways.
Xiuli Chen, Hao Wu, Peibo Li, Wei Peng, Yonggang Wang, Xiaoli Zhang, Ao Zhang, Jinliang Li, Fenzhao Meng, Weiyue Wang, Weiwei Su   +10 more
doaj   +1 more source

Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study. [PDF]

, 1995
Homogenates of chick dorsal root ganglia (DRG) and in vitro cultures of DRG neurons are known to synthesize prostaglandin (PG) D2. To specify the PGD synthase isozymes controlling PGD2 synthesis in DRG and to identify the DRG cells responsible for this ...
Droz, B., Hayaishi, O., Urade, Y., Vesin, M.F.   +3 more
core   +1 more source

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]

, 2020
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar, Grieben, Ulrike, Grunwald, Stefanie Anke, Haafke, Stefanie, Jedraszczak, Nicole, Kress, Wolfram, Patone, Giannino, Popp, Oliver, Saar, Kathrin, Spuler, Simone, Steinhagen-Thiessen, Elisabeth   +10 more
core   +1 more source

In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]

, 2010
The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg, Goltsov, Alexey, Goltsov, Gregory, Goryanin, Igor, Humphery-Smith, Ian, Lebedeva, Galina   +5 more
core   +5 more sources

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source