Results 31 to 40 of about 27,427 (303)

Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy

Journal of Diabetes Research, 2016
Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2
Lei Pang, Yin Cai, Eva Hoi Ching Tang, Michael G. Irwin, Haichun Ma, Zhengyuan Xia   +5 more
doaj   +1 more source

Reciprocal interactions between prostaglandin E2- and estradiol-dependent signaling pathways in the injured zebra finch brain

Journal of Neuroinflammation, 2017
Background Astrocytic aromatization and consequent increases in estradiol are neuroprotective in the injured brain. In zebra finches, cyclooxygenase-activity is necessary for injury-induced aromatase expression, and increased central estradiol lowers ...
Alyssa L. Pedersen, Colin J. Saldanha
doaj   +1 more source

Control of cytokine production from human monocytic cells by prostaglandin 15-Deoxy-Δ-12,14-prostaglandin J2 [PDF]

, 2018
Prostaglandins have several roles, but their main function is within the inflammatory process. As part of the immune response, immune cells are stimulated by lipopolysaccharide to produce pro- and anti-inflammatory cytokines including tumour necrosis ...
McCourtney, Christopher
core   +1 more source

Inhibition of Hatching of Mouse Blastocysts in vitro by Prostaglandin Antagonists [PDF]

Biology of Reproduction, 1978
The escape of the blastocyst from the zona pellucida in vitro is probably the result of expansion due to fluid accumulation in the blastocoele. This fluid accumulation is mediated by the epithelial trophectoderm. Since prostagiandins of the E series are involved in the control of water movement across epithelia, the effect of prostaglandin antagonists ...
J D, Biggers, B V, Leonov, J F, Baskar, J, Fried   +3 more
openaire   +2 more sources

Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
core   +1 more source

Reduction of fertility of mice by the intrauterine injection of prostaglandin antagonists [PDF]

Reproduction, 1981
Summary. The intrauterine injection of 7-oxa-13-prostynoic acid, 18,18,20-trimethyl PGE-2, and meclofenamic acid in mice at the expected times of implantation significantly reduced the number of implantation sites. Indomethacin was ineffective possibly because it was exposed to high pH during the preparation of the solutions for ...
J D, Biggers, J F, Baskar, D F, Torchiana   +2 more
openaire   +2 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Prevention of Preterm Labour: 2011 Update on Tocolysis

Journal of Pregnancy, 2011
The aim of this paper is to review available data about drugs for preventing preterm labour. Tocolytic therapy includes β adrenergic receptor agonists, NO donors, magnesium sulphate, prostaglandin-synthase inhibitors, oxytocin receptor antagonists ...
C. Hubinont, F. Debieve
doaj   +1 more source

Lipopolysaccharide- and Glutamate-Induced Hypothalamic Hydroxyl Radical Elevation and Fever Can Be Suppressed by N-Methyl-D-aspartate-Receptor Antagonists

Journal of Pharmacological Sciences, 2007
The purpose of the current study was to explore the effects of N-methyl-D-aspartate (NMDA)-receptor antagonists (MK-801 and LY235959) administered intracerebroventricularly on the changes of both core temperature and hypothalamic levels of 2,3 ...
Cheng-Hsing Kao, Ting-Yu Kao, Wu-Tein Huang, Mao-Tsun Lin   +3 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source