Results 11 to 20 of about 27,427 (303)
CRTH2 antagonists in asthma: current perspectives [PDF]
Clinical Pharmacology: Advances and Applications, 2017 Dave Singh, Arjun Ravi, Thomas Southworth Division of Infection, Immunity and Respiratory Medicine, The Medicines Evaluation Unit, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, The University of ...
Singh D, Ravi A, Southworth T
doaj +1 more source
Polyphloretin phosphate (PPP) antagonists of prostaglandin action also inhibit prostaglandin biosynthesis in-vitro [PDF]
Journal of Pharmacy and Pharmacology, 1990 Abstract Several polyphloretin phosphate (PPP) fractions (low mol. wt LC1259; high mol. wt LC1261; crude mixture, LC101) were confirmed in their established property as antagonists of the pharmacological actions of prostaglandins in a preparation of guinea-pig isolated ileum stimulated by prostaglandin (PG)E2. Further samples of the same
P B, Curtis-Prior +4 more
openaire +3 more sources
Frontiers in Physiology, 2020 Current pharmacological treatment options for many bladder contractile dysfunctions are not suitable for all patients, thereby bringing interest to the investigation of therapies that target a combination of receptors.
Zane Stromberga +2 more
doaj +1 more source
Discovery of Novel, Selective Prostaglandin EP4 Receptor Antagonists with Efficacy in Cancer Models [PDF]
, 2023 Prostaglandin E2 (PGE2) receptor 4 (EP4) is one of four EP receptors commonly upregulated in the tumor microenvironment and plays vital roles in stimulating cell proliferation, invasion, and metastasis.
Dandan Qiao (5865554) +8 more
core +1 more source
Postepy higieny i medycyny doswiadczalnej, 1980 This study examined the antinociceptive effects of two prostaglandin antagonists, SC-25469 and SC-19220 in the rat. SC-25469 and SC-19220 inhibited acetic acid-induced writhing with ED50 s of 6.9 and 6.8 mg/kg p.o., respectively. When compared to other analgesics, the rank order of potency in the writhing test was morphine greater than pentazocine = U ...
R, Brus, J, Zabawska
openaire +4 more sources
Pharmacotherapy of glaucoma in terms of evidence-based medicine
Качественная клиническая практика, 2023 Glaucoma is a disease associated with increased intraocular pressure (IOP). Of the pharmacological agents for treating glaucoma, there are drugs of the first (most effective and safe) and second-line treatment. First-line treatment includes prostaglandin
V. N. Fedorov +6 more
doaj +1 more source
Anti-platelet therapy: ADP receptor antagonists. [PDF]
, 2011 The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S +3 more
core +1 more source
Perioperative uses of histamine antagonists [PDF]
, 1990 Histamine release and adverse pseudoallergic/allergic reactions during the perioperative period occur frequently. The incidence of such reactions is 20%-30% for all grades of severity, 1%-5% for systemic reactions, and 0.1%-0.5% for life-threatening ...
Lorenz, Wilfried +3 more
core +1 more source
Role of protein kinase C in renal vasoconstriction caused by angiotensin II [PDF]
, 1990 In this study we have examined the subcellar pathways along which angiotensin II (ANG II) causes renal vasoconstriction. Using the isolated perfused rat kidney model, we found that renal vasoconstriction produced by ANG II (100 pM) was not altered by the
Kurtz, Armin +3 more
core +1 more source
Are hypotension and rash after atracurium really caused by histamine release? [PDF]
, 1994 A prospective, randomized, double-blind study was performed in 40 patients (ASA class I-III) treated with atracurium to ascertain whether histamine release caused hemodynamic or cutaneous changes.
Doenicke, A. +4 more
core +1 more source