Results 1 to 10 of about 27,427 (303)
Docking for EP4R antagonists active against inflammatory pain [PDF]
Nature Communications, 2023 The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R).
Stefan Gahbauer +18 more
doaj +6 more sources
Structural insights into selective and dual antagonism of EP2 and EP4 prostaglandin receptors [PDF]
The EMBO JournalProstaglandin E2 (PGE2) signaling through EP2 and EP4 receptors is crucial in regulating inflammation, pain, and cancer progression. While selective and dual antagonists for these receptors hold therapeutic potential, their binding mechanisms and ...
Yanli Wu +8 more
doaj +2 more sources
Advances in chemoprevention of familial adenomatous polyposis [PDF]
Frontiers in OncologyFamilial adenomatous polyposis (FAP) is an autosomal dominant hereditary disease characterized by the early onset of numerous intestinal polyps, which, if untreated, may progress to colon cancer.
Ruicheng Li +9 more
doaj +2 more sources
Candida albicans colonization modulates murine ethanol consumption and behavioral responses through elevation of serum prostaglandin E2 and impact on the striatal dopamine system [PDF]
mBioCandida albicans is a commensal yeast that is a common component of the gastrointestinal (GI) microbiome of humans. C. albicans has been shown to bloom in the GI tract of individuals with alcohol use disorder (AUD) and can promote and increase the ...
Andrew W. Day +6 more
doaj +2 more sources
Life Science Alliance, 2022 PGD2 is a major brain prostaglandin and we report that timapiprant that is an antagonist for the PGD2 receptor DP2 reduces pathology and cognitive deficits in a transgenic rat model of Alzheimer’s.
Charles H Wallace +5 more
doaj +1 more source
Studies on prostaglandin antagonists [PDF]
British Journal of Pharmacology, 1971 Summary Three prostaglandin antagonists have been examined for their ability to block PGE2 and PGF2α on human, guinea‐pig and isolated rat gastrointestinal muscle. 7‐oxa‐13‐Prostynoic acid was either a non‐selective antagonist, or was ineffective on the tissues studied; it had marked spasmogenic activity on the rat fundus.
A, Bennett, J, Posner
openaire +2 more sources
Cyclooxygenase-2-Prostaglandin E2 pathway: A key player in tumor-associated immune cells
Frontiers in Oncology, 2023 Cyclooxygenases-2 (COX-2) and Prostaglandin E2 (PGE2), which are important in chronic inflammatory diseases, can increase tumor incidence and promote tumor growth and metastasis.
Kaipeng Jin +11 more
doaj +1 more source
BMC Gastroenterology, 2022 Background Aberrations in cyclooxygenase and lipoxygenase (LOX) pathways in non-neoplastic, normal appearing mucosa from patients with colorectal neoplasia (CRN), could hypothetically qualify as predisposing CRN-markers.
Ulrike Ries Feddersen +5 more
doaj +1 more source
Prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017.
PLoS ONE, 2020 ObjectiveTo evaluate the prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017.MethodsA descriptive analysis using pharmacy prescription data was conducted.
Lingyan Yu +3 more
doaj +1 more source
Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death
Scientific Reports, 2021 Proximal tubular cells (PTC) are particularly vulnerable to hypoxia-induced apoptosis, a relevant factor for kidney disease. We hypothesized here that PTC death under hypoxia is mediated by cyclo-oxygenase (COX-2)-dependent production of prostaglandin E2
Coral García-Pastor +4 more
doaj +1 more source