Results 31 to 40 of about 373,954 (298)
Improved homology modeling of the human & rat EP4 prostanoid receptors
BMC Molecular and Cell Biology, 2019 Background The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and promote development of ...
Melissa C. Holt +4 more
doaj +1 more source
Purinergic Signaling Induces Cyclooxygenase-1-Dependent Prostanoid Synthesis in Microglia: Roles in the Outcome of Excitotoxic Brain Injury [PDF]
, 2011 Cyclooxygenases (COX) are prostanoid synthesizing enzymes constitutively expressed in the brain that contribute to excitotoxic neuronal cell death. While the neurotoxic role of COX-2 is well established and has been linked to prostaglandin E2 synthesis ...
Camile Gooden +8 more
core +2 more sources
Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
Nature Communications, 2019 Whether sensory nerve can sense bone density or metabolic activity to control bone homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by osteoblastic cells activates PGE2 receptor 4 (EP4) in sensory nerves to regulate bone formation ...
Hao Chen +21 more
semanticscholar +1 more source
Modeling of biological doses and mechanical effects on bone transduction [PDF]
Journal of Theoretical Biology 274, 1 (2011) 36-42, 2011 Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic doses in stimulus signal level on bone.
arxiv +1 more source
Prostaglandin E2/EP Signaling in the Tumor Microenvironment of Colorectal Cancer
International Journal of Molecular Sciences, 2019 The number of colorectal cancer (CRC) patients is increasing worldwide. Accumulating evidence has shown that the tumor microenvironment (TME), including macrophages, neutrophils, and fibroblasts, plays an important role in the development and progression
Rei Mizuno, K. Kawada, Y. Sakai
semanticscholar +1 more source
Termination of Pregnancy: Misoprostol Versus Prostaglandin E2
Pakistan Armed Forces Medical Journal, 2023 Objective: To compare the efficacy of vaginal Misoprostol and vaginal prostaglandin E2 in termination of pregnancy. Study Design: Quasi-experimental study.
Imama Tul Bushra +5 more
doaj +1 more source
Effect of Nonsteroid Anti-Inflammatory and Antipyretic Drugs on Prostaglandin Biosynthesis by Human Skin [PDF]
, 1973 There is increasing evidence that prostaglandins are mediators of inflammation in skin and that prostaglandins are synthesised locally in response to the inflammatory stimulus.
Greaves, Malcolm W. +1 more
core +1 more source
Ensho Saisei, 2000 Prostaglandin E synthase (PGES) catalyzes isomerization of PGH2to PGE2which exhibits potent and various biological activities. Here we report the molecular identification of two distinct glutathione-dependent PGESs, the terminal PGE2-biosynthetic enzymes of the cyclooxygenase (COX) pathway.
Yoshihito Nakatani +2 more
openaire +2 more sources
From Resource Auction to Service Auction: An Auction Paradigm Shift in Wireless Networks [PDF]
Volume: 29, Issue: 2, April 2022, 2022 In 5G and beyond, the newly emerging services, such as edge computing/intelligence services, may demand the provision of heterogeneous communications, computing, and storage (CCS) resources on and across network entities multihop apart. In such cases, traditional resource-oriented auction schemes, where buyers place bids on resources, may not be ...
arxiv +1 more source
Effects of male attractiveness on prostaglandin E2 production levels [PDF]
, 2023 Sexual conflict or sexual antagonism can encourage co-evolution between males and females of a given species. In house crickets (Acheta domesticus), unattractive (smaller) and attractive (larger) males seem to use differential allocation of prostaglandin
Cousins, Kyra
core +1 more source