Results 121 to 130 of about 363,420 (397)

Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β‐Adrenergic Activation

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study explores the roles of cardiomyocyte‐ and cardiac fibroblast‐specific EP4 in isoproterenol‐induced cardiac fibrosis. The findings reveal that EP4 inhibition improves diastolic function and reduces fibrosis by modulating TGF‐β1 signaling and extracellular matrix protein production.
Hu Xu, Xiuhui Mao, Yali Wang, Chunhua Zhu, Bo Liang, Yihang Zhao, Mengfei Zhou, Lan Ye, Mengting Hong, Huishu Shao, Yashuo Wang, Haonan Li, Yinghui Qi, Yongliang Yang, Lihong Chen, Youfei Guan, Xiaoyan Zhang   +16 more
wiley   +1 more source

Changes in PGE2 signaling after submandibulectomy alter post–tooth extraction socket healing [PDF]

, 2018
Saliva is very important to oral health, and a salivary deficit has been shown to bring serious problems to oral health. There is scant information about the mechanisms through which salivary glands participate in post–tooth extraction socket healing ...
Bozzini, Clarisa, Conti, María Inés, Elverdín, Juan Carlos, Fernández Solari, José Javier, Mohn, Claudia Ester, Troncoso, Gastón Rodolfo   +5 more
core   +1 more source

Metabolism of Prostaglandins in Rat Liver Mitochondria [PDF]

, 1968
Mats Hámberg
openalex   +1 more source

Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling[S]

Journal of Lipid Research, 2019
Lysophospholipids (LysoPLs) are bioactive lipid species involved in cellular signaling processes and the regulation of cell membrane structure. LysoPLs are metabolized through the action of lysophospholipases, including lysophospholipase A1 (LYPLA1) and ...
James A. Wepy, James J. Galligan, Philip J. Kingsley, Shu Xu, Michael C. Goodman, Keri A. Tallman, Carol A. Rouzer, Lawrence J. Marnett   +7 more
doaj  

The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins

Frontiers in Cellular Neuroscience, 2018
Preterm birth is a major cause for neonatal morbidity and mortality, and is frequently associated with adverse neurological outcomes. The transition from intrauterine to extrauterine life at birth is particularly challenging for preterm infants. The main
Vanesa Stojanovska, Suzanne L. Miller, Suzanne L. Miller, Stuart B. Hooper, Stuart B. Hooper, Graeme R. Polglase, Graeme R. Polglase   +6 more
doaj   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor [PDF]

, 2020
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Stimulation of Thyroid Metabolism by Thyrotropin, Cyclic 3': 5'-AMP, Dibutyryl Cyclic 3':5'-AMP and Prostaglandin E1 [PDF]

, 1969
F Rodesch, Paul Neve, Christiana Willems, J.E. Dumont   +3 more
openalex   +1 more source

Annonaceae: Breaking the Wall of Inflammation

Frontiers in Pharmacology, 2017
Inventories of tropical forests have listed Annonaceae as one of the most diverse plant families. For centuries, it is employed in traditional medicines to cure various pathological conditions including snakebite, analgesic, astringent, diarrhea ...
Ali Attiq, Juriyati Jalil, Khairana Husain   +2 more
doaj   +1 more source

Mannose‐Glycated Metal‐Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy

Advanced Science, Volume 12, Issue 16, April 24, 2025.
Immunomodulatory metal‐phenolic microcapsules (mMPMs) is developed in this study that leverages dopamine‐modified hyaluronic acid and FeIII assemble on mannose‐glycated bovine serum albumin microbubbles. mMPMs effectively promote macrophage internalization and M1 polarization, enhancing pro‐inflammatory responses.
Xin Tan, Renwang Sheng, Weikun Li, Yinghua Tao, Zonghao Liu, Ning Yang, Syeda Safia Hashmi, Feiling Feng, Fangzhou Liu, Liqin Ge   +9 more
wiley   +1 more source