Gastroprotective effect of zafirlukast against indomethacin induced gastric ulcer in rats via PGE2 and anti-inflammatory pathways [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To evaluate the gastroprotective potential of zafirlukast against indomethacin-induced gastric ulcers in rats.Materials and Methods: Thirty-two male Wistar rats were included in this study and randomly divided into 4 equal groups (n=8 ...
Munaf Aal-Aaboda +3 more
doaj +1 more source
Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]
, 2013 Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V. +9 more
core +18 more sources
Prostaglandin E Receptors [PDF]
Journal of Biological Chemistry, 2007 Prostaglandin (PG) E(2) exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs responding to PGE(2) designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3. The EP subtypes exhibit differences in signal transduction, tissue localization, and regulation of expression ...
Yukihiko, Sugimoto, Shuh, Narumiya
openaire +2 more sources
The role of some lipids and their metabolites in programmed cell death (lipoapoptosis).
Acta Biomedica Scientifica, 2022 In recent years, the understanding of the mechanisms involved in the regulation of lipoapoptosis signaling pathways has expanded considerably. However, many mechanisms of apoptosis induction by lipids as well as molecules mediating intracellular and ...
N. A. Ishutina, I. A. Andrievskaya
doaj +1 more source
Integrated analysis of COX-2 and iNOS derived inflammatory mediators in LPS-stimulated RAW macrophages pre-exposed to Echium plantagineum L. bee pollen extract. [PDF]
PLoS ONE, 2013 Oxidative stress and inflammation play important roles in disease development. This study intended to evaluate the anti-inflammatory and antioxidant potential of Echium plantagineum L. bee pollen to support its claimed health beneficial effects.
Eduarda Moita +8 more
doaj +1 more source
Combination therapy with butyrate and docosahexaenoic acid for keloid fibrogenesis: an in vitro study [PDF]
Anais Brasileiros de Dermatologia, 2017 : Background: A single, effective therapeutic regimen for keloids has not been established yet, and the development of novel therapeutic approaches is expected.
Kazuhiro Torii +5 more
doaj +1 more source
Nature Communications, 2023 Prostaglandins and their receptors regulate various physiological processes. Carboprost, an analog of prostaglandin F2α and an agonist for the prostaglandin F2-alpha receptor (FP receptor), is clinically used to treat postpartum hemorrhage (PPH). However,
Xiuqing Lv +12 more
doaj +1 more source
Prostaglandin E Synthases in Zebrafish [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Objective— Prostaglandin E synthases (PGESs) are being explored as antiinflammtory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE 2 formation, and deletion of microsomal (m)-PGES-1 abrogates inflammation ...
Pini, Barbara +5 more
openaire +2 more sources
Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease. [PDF]
PLoS ONE, 2012 The contribution of inflammation to the pathogenesis of tendinopathy and high prevalence of re-injury is not well established, although recent evidence suggests involvement of prostaglandins.
Stephanie Georgina Dakin +5 more
doaj +1 more source
Heliyon, 2023 Background: Most labor-related problems can be attributed to the uterine myometrium muscle, as this irritable tissue must suppress its irritability potential during pregnancy.
Farideh Zafari Zangeneh +1 more
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