Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E2 Biosynthesis [PDF]
BMB Reports, 2005 Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties ...
Ichiro, Kudo, Makoto, Murakami
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Do stress responses promote leukemia progression? An animal study suggesting a role for epinephrine and prostaglandin-E2 through reduced NK activity. [PDF]
PLoS ONE, 2011 In leukemia patients, stress and anxiety were suggested to predict poorer prognosis. Oncological patients experience ample physiological and psychological stress, potentially leading to increased secretion of stress factors, including epinephrine ...
Shelly Inbar +5 more
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Prostaglandin synthesis in rat adrenocortical cells.
Journal of Lipid Research, 1979 The biosynthesis of prostaglandins by isolated rat adrenocortical cells has been studied by determinations of products formed during incubations with labeled arachidonic acid and by radioimmunoassays.
R Chanderbhan +3 more
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Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]
, 2018 Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A. +6 more
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Contribution of PGE2 EP1 receptor in hemin-induced neurotoxicity
Frontiers in Molecular Neuroscience, 2013 Although hemin-mediated neurotoxicity has been linked to the production of free radicals and glutamate excitotoxicity, the role of the prostaglandin E2 (PGE2)-EP1 receptor remains unclear.
Shekher eMohan +4 more
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Hypothyroidism Affects Uterine Function via the Modulation of Prostaglandin Signaling
Animals, 2021 Thyroid hormones control the functions of almost all body systems. Reproductive dysfunctions, such as abnormal sexual development, infertility, or irregularities in the reproductive cycle, might be associated with thyroid disorders.
Ilona Kowalczyk-Zieba +5 more
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Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma. [PDF]
, 2019 BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology.
Gibson, Robert A +8 more
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Dehydration of prostaglandins: study by spectroscopic method
Journal of Lipid Research, 1969 The ultraviolet (UV) and optical rotatory dispersion (ORD) spectra of prostaglandins E1, A1, B1, and their naturally derived 15-epimers are presented.
Niels H. Andersen
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Insights into the prostanoid pathway in the ovary development of the penaeid shrimp Penaeus monodon. [PDF]
PLoS ONE, 2013 The prostanoid pathway converts polyunsaturated fatty acids (PUFAs) into bioactive lipid mediators, including prostaglandins, thromboxanes and prostacyclins, all of which play vital roles in the immune and reproductive systems in most animal phyla.
Wananit Wimuttisuk +6 more
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Journal of Biological Chemistry, 2001 Electrophilic eicosanoids of the J series, with their distinctive cross-conjugated α,β-unsaturated ketone, inactivate genetically wild type tumor suppressor p53 in a manner analogous to prostaglandins of the A series.
J. Mullally +3 more
semanticscholar +1 more source