Results 271 to 280 of about 63,897 (315)
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ChemInform Abstract: STEREOSELECTIVE REDUCTION OF PROSTAGLANDINS E TO PROSTAGLANDINS F
Chemischer Informationsdienst, 1980AbstractDie Prostaglandine E (I) gehen bei der Reduktion mit Li in Tetrahydrofuran und flüssigem Ammoniak in die Prostaglandine Fß(II) über.
K. K. Pivnitskii, V. I. Mel'nikova
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Stability of E-Type Prostaglandins in Triacetin
Journal of Pharmaceutical Sciences, 1979A drug delivery system for E-type prostaglandins is described. In this system, consisting of drug dissolved in triacetin and filled into soft gelatin capsules, normally unstable prostaglandins show excellent stability at room temperature.
T.J. Roseman, Samuel H. Yalkowsky
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The immunomodulatory actions of E-type prostaglandins
Expert Opinion on Investigational Drugs, 1997Prostaglandins (PGs) have been recognised as modulators of immune responses. This has been proved by both in vitro studies and from observations in animals and humans. Administration of prostaglandins for therapeutic purposes, however, has been hampered by their limited bioavailability and their pleiotropic effects, with resultant toxicological profile.
J Rhodes, GW De Vries, A McLaughlin
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Prostaglandin E synthase in the pathophysiology of arthritis
Fundamental & Clinical Pharmacology, 2005AbstractProstaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane‐associated PGES (mPGES)‐1, mPGES‐2, and cytosolic PGES.
Shinichi Kawai +3 more
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Depression, immunocompetence, and prostaglandins of the E series
Psychiatry Research, 1986Plasma prostaglandin E1 and E2, and quantitative and qualitative measures of immune function, were determined in depressed patients and healthy controls. Prostaglandin E2 was significantly elevated in the depressed group, and prostaglandin E1 showed a trend in the same direction.
Neal E. Krupp +7 more
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Measurement of prostaglandin E in crevicular fluid
Journal of Clinical Periodontology, 1981Abstract A method for the detection of prostaglandin E (PGE) in crevicular fluid has been developed which provides a sensitive, noninvasive technique for measurement of local concentrations of this mediator of inflammation. Assay sensitivity sufficient for the detection of 4 picograms of PGE2; was achieved by utilizing a high‐affinity anti‐PGE2 ...
J. M. Goodson +2 more
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The content of prostaglandin E and prostaglandin F2α in the exudate of carrageenin granuloma of rats
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 19761. Granuloma was made by the subcutaneous injection of 2% carrageenin solution on the dorsum of male rats. Eight, 16, 24 and 72 h after the injection. the exudate from each rat granuloma was withdrawn and extracted for rpstaglandins. 2. Extracted prostaglandins were separated prostaglandin E and prostaglandin F group by silicic acid mini-column ...
Hiroshi Sato +2 more
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
Abstract The reduction of the glutathione conjugate of prostaglandin A1 by avian prostaglandin E 9-ketoreductase occurs at a faster rate than reduction of its presumed natural substrates, prostaglandin E1 or E2.
Lauren M. Cagen, John J. Pisano
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Abstract The reduction of the glutathione conjugate of prostaglandin A1 by avian prostaglandin E 9-ketoreductase occurs at a faster rate than reduction of its presumed natural substrates, prostaglandin E1 or E2.
Lauren M. Cagen, John J. Pisano
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Biochemical and Biophysical Research Communications, 1997
Prostaglandin (PG) E synthase was found to be widely distributed in the microsomal fractions of rat organs. Among them, an extremely high activity was seen in the deferent duct (112 nmol/min x mg) and other genital accessory organs (10-20 nmol/min x mg). In non-genital organs, the kidney had the highest activity (8 nmol/min x mg).
Osamu Hayaishi +3 more
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Prostaglandin (PG) E synthase was found to be widely distributed in the microsomal fractions of rat organs. Among them, an extremely high activity was seen in the deferent duct (112 nmol/min x mg) and other genital accessory organs (10-20 nmol/min x mg). In non-genital organs, the kidney had the highest activity (8 nmol/min x mg).
Osamu Hayaishi +3 more
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American Review of Respiratory Disease, 1991
Prostaglandin E (PGE), a cyclooxygenase metabolite normally present in high concentrations in respiratory epithelial lining fluid (ELF), is capable of suppressing mesenchymal cell proliferation mediated by polypeptide-derived growth factors. Although PGE is normally abundant in respiratory ELF, PGE levels in ELF of individuals with idiopathic pulmonary
Toshio Ozaki +7 more
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Prostaglandin E (PGE), a cyclooxygenase metabolite normally present in high concentrations in respiratory epithelial lining fluid (ELF), is capable of suppressing mesenchymal cell proliferation mediated by polypeptide-derived growth factors. Although PGE is normally abundant in respiratory ELF, PGE levels in ELF of individuals with idiopathic pulmonary
Toshio Ozaki +7 more
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