Results 21 to 30 of about 18,922,836 (351)
Lipids in Health and Disease, 2023 Oxylipins are derived from enzymatic and non-enzymatic oxidation of n-3 and n-6 long-chain polyunsaturated fatty acids. They are known to be involved in inflammatory processes.
Hélène Fougère +7 more
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Pharmacology Research & Perspectives, 2021 Chronic elevations in fatty acid metabolites termed prostaglandins can be found in circulation and in pancreatic islets from mice or humans with diabetes and have been suggested as contributing to the β‐cell dysfunction of the disease.
Harpreet K. Sandhu +10 more
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Pharmaceutical Biology, 2022 Context The gastroprotective effect of Heliotropium indicum L. (Boraginaceae), a plant traditionally used in Mexico to treat gastric ulcers, has been previously reported. However, no active compound was identified.Objective The current contribution aimed
Yaraset López-Lorenzo +4 more
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Upregulation of prostaglandin E2 by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose: Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE<sub>2</sub> include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH).
Young Hun Kim, Kyung Jong Kim
openaire +3 more sources
Plasma oxylipins and unesterified precursor fatty acids are altered by DHA supplementation in pregnancy: Can they help predict risk of preterm birth? [PDF]
, 2019 Oxidized lipids derived from omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids, collectively known as oxylipins, are bioactive signaling molecules that play diverse roles in human health and disease.
Best, Karen +9 more
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Revista Mexicana de Oftalmología, 2023 Objective: Femtosecond laser-assisted cataract surgery (FLACS) is a treatment with increasing popularity. However, inflammation generated by the laser remains a subject of research.
Claudia Palacio-Pastrana +7 more
doaj +1 more source
Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma. [PDF]
, 2019 BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology.
Gibson, Robert A +8 more
core +1 more source
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]
, 2007 Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico +8 more
core +1 more source
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.
Arthritis research & therapy, 2005 Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Seetha U. Monrad +2 more
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Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]
, 2013 Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V. +9 more
core +3 more sources