BMC Cancer, 2018 Background Bleomycin, etoposide, and cisplatin (BEP) chemotherapy administered every 3 weeks for 4 cycles remains the standard first line treatment for patients with intermediate- and poor-risk metastatic germ cell tumours (GCTs).
Nicola J. Lawrence +16 more
doaj +1 more source
A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes
npj Precision Oncology, 2023 Specific classes of DNA damage repair (DDR) defect can drive sensitivity to emerging therapies for metastatic prostate cancer. However, biomarker approaches based on DDR gene sequencing do not accurately predict DDR deficiency or treatment benefit ...
Elie J. Ritch +14 more
doaj +1 more source
Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis [PDF]
, 2015 In comparison to more differentiated cells, prostate cancer stem-like cells are radioresistant, which could explain radio-recurrent prostate cancer. Improvement of radiotherapeutic efficacy may therefore require combination therapy.
Boyle, Ross W. +7 more
core +1 more source
Scientific Reports, 2022 The quality of life (QoL) of men with optimal outcomes after robot-assisted radical prostatectomy (RARP) is largely unexplored. Thus we assessed meaningful changes of QoL measured with the EORTC QLQ-C30 24 months after RARP according to postsurgical ...
Theodoros Karagiotis +11 more
doaj +1 more source
Inflammation in benign prostate tissue and prostate cancer in the finasteride arm of the Prostate Cancer Prevention Trial [PDF]
, 2016 BACKGROUND: A previous analysis of the placebo arm of the Prostate Cancer Prevention Trial (PCPT) reported 82% overall prevalence of intraprostatic inflammation and identified a link between inflammation and higher-grade prostate cancer and serum PSA ...
Barber, John R +15 more
core +2 more sources
The human gastrointestinal microbiota and prostate cancer development and treatment [PDF]
, 2020 The human gastrointestinal microbiome contains commensal bacteria and other microbiota that have been gaining increasing attention in the context of cancer development and response to treatment.
Alanee +70 more
core +1 more source
BMC Urology, 2022 Background To report the feasibility, oncological and functional outcomes of salvage robot-assisted radical prostatectomy (sRARP) for recurrent prostate cancer (PCa) after irreversible electroporation (IRE).
Alexandar Blazevski +11 more
doaj +1 more source
Prostate cancer incidence in Golestan province, Iran (2004) [PDF]
, 2008 Prostate cancer is the most common cancer in men and therefore represents a major problem in public health.The aim of this study was to find and evaluate province-specific estimate of incidence in males by age groups for prostate cancer in Golestan ...
Kabir, M.J., Marjani, A.
core +1 more source
Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells [PDF]
, 2013 The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new ...
Brinkmann +36 more
core +1 more source
Multiparametric magnetic resonance imaging of the prostate-a basic tutorial. [PDF]
, 2017 Prostate cancer is the second most common cause of cancer related death in the United States and the most commonly diagnosed malignancy in men. In general, prostate cancer is slow growing, though there is a broad spectrum of disease that may be indolent,
Cabarrus, Miguel C +1 more
core +1 more source