Results 1 to 10 of about 1,598,143 (384)

Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis

Frontiers in Medicine, 2023
ObjectivesOur objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics.BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-established ...
Camilla Margaroli, Camilla Margaroli, Paul Benson, Maria G. Gastanadui, Maria G. Gastanadui, Chunyan Song, Chunyan Song, Chunyan Song, Liliana Viera, Liliana Viera, Liliana Viera, Dongqi Xing, Dongqi Xing, Dongqi Xing, Dongqi Xing, Dongqi Xing, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, Rakesh Patel, Rakesh Patel, Rakesh Patel, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne   +37 more
doaj   +1 more source

Diet, microbiota, and the mucus layer: The guardians of our health

Frontiers in Immunology, 2022
The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of the host representing one of the main external factors ...
Francesco Suriano, Elisabeth E. L. Nyström, Domenico Sergi, Jenny K. Gustafsson   +3 more
doaj   +1 more source

Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

Frontiers in Neuroscience, 2021
The human tau protein is implicated in a wide range of neurodegenerative “tauopathy” diseases, consisting of Alzheimer’s disease (AD) and frontotemporal lobar degeneration which includes progressive supranuclear palsy, corticobasal degeneration, Pick’s ...
Ben Boyarko, Vivian Hook, Vivian Hook
doaj   +1 more source

Investigating Fungi-Derived Bioactive Molecules as Inhibitor of the SARS Coronavirus Papain Like Protease: Computational Based Study

Frontiers in Medicine, 2021
Due to the rapid growth of the COVID-19 pandemic and its outcomes, developing a remedy to fight the predicament is critical. So far, it has infected more than 214,468,601 million people and caused the death of 4,470,969 million people according to the ...
Aweke Mulu Belachew, Asheber Feyisa, Seid Belay Mohamed, Jerusalem Fekadu W/Mariam   +3 more
doaj   +1 more source

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Science, 2020
Targeting a key enzyme in SARS-CoV-2 Scientists across the world are working to understand severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). Zhang et al.
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, U. Curth, C. Drosten, Lucie Sauerhering, S. Becker, K. Rox, R. Hilgenfeld   +8 more
semanticscholar   +1 more source

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Science, 2020
Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments.
Wenhao Dai, Bing Zhang, Xiaming Jiang, H. Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, X. Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Z. Rao, Lei-ke Zhang, Yechun Xu, Haitao Yang, Hong Liu   +26 more
semanticscholar   +1 more source

Proteolytic Regulation of the Lectin-Like Oxidized Lipoprotein Receptor LOX-1

Frontiers in Cardiovascular Medicine, 2021
The lectin-like oxidized-LDL (oxLDL) receptor LOX-1, which is broadly expressed in vascular cells, represents a key mediator of endothelial activation and dysfunction in atherosclerotic plaque development.
Torben Mentrup, Florencia Cabrera-Cabrera, Bernd Schröder   +2 more
doaj   +1 more source

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Nature Communications, 2021
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs.
B. Boras, Rhys M. Jones, B. Anson, D. Arenson, L. Aschenbrenner, M. Bakowski, N. Beutler, Joseph Binder, Emily Chen, H. Eng, Holly Hammond, J. Hammond, Robert E. Haupt, R. Hoffman, E. Kadar, R. Kania, Emi Kimoto, Melanie G. Kirkpatrick, L. Lanyon, E. Lendy, Jonathan R. Lillis, James Logue, S. Luthra, Chunlong Ma, S. Mason, M. McGrath, Stephen Noell, R. Obach, Matthew N. O’ Brien, Rebecca E O'connor, Kevin Ogilvie, D. Owen, Martin Pettersson, M. Reese, T. Rogers, R. Rosales, M. Rossulek, J. Sathish, N. Shirai, C. Steppan, M. Ticehurst, L. Updyke, S. Weston, Yuao Zhu, K. White, A. García-Sastre, Jun Wang, A. Chatterjee, A. Mesecar, M. Frieman, A. Anderson, C. Allerton   +51 more
semanticscholar   +1 more source

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]

, 2012
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Aksam, Antonenkov, Arnold, Bartoszewska, Bender, Bota, Buchner, Dobson, Ellis, Fraaije, Franke, Goldberg, Guinier, Hanson, Hartl, Hillenga, Islinger, Iyer, Jaenicke, Jahn, Kiel, Kiel, Kikuchi, Kozin, Lee, Lingard, Liu, Meijer, Nettleship, Nijland, Okumoto, Omi, Opaliński, Paraszkiewicz, Petoukhov, Petoukhov, Petoukhov, Powers, Quiocho, Reeder, Rep, Roessle, Roudiak, Sambrook, Sauer, Stahlberg, Steinberg, Svergun, Tyedmers, van Dijken, van Roermund, Venkatesh, Volkov, von Janowsky, Wagner, Walton, Wanders, Waterham, West   +58 more
core   +10 more sources

Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential

Frontiers in Molecular Biosciences, 2021
Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt, Heike Brötz-Oesterhelt, Andreas Vorbach   +2 more
doaj   +1 more source