Results 1 to 10 of about 580,293 (310)
In silico prediction of mutant HIV-1 proteases cleaving a target sequence [PDF]
PLOS ONE Volume:9 Issue: 5 Page: e95833 (2014), 2014 HIV-1 protease represents an appealing system for directed enzyme re-design, since it has various different endogenous targets, a relatively simple structure and it is well studied. Recently Chaudhury and Gray (Structure (2009) 17: 1636 -- 1648) published a computational algorithm to discern the specificity determining residues of HIV-1 protease.
De Vico, Luca +3 more
arxiv +8 more sources
Evolutionary Multi-Objective Design of SARS-CoV-2 Protease Inhibitor Candidates [PDF]
LNCS 12270 (2020) 357-371, 2020 Computational drug design based on artificial intelligence is an emerging research area. At the time of writing this paper, the world suffers from an outbreak of the coronavirus SARS-CoV-2. A promising way to stop the virus replication is via protease inhibition.
A Alhossary +24 more
arxiv +3 more sources
Crucial stages of protein folding through a solvable model: predicting target sites for enzyme-inhibiting drugs [PDF]
Protein Science, Vol.11, p. 1878-1887 (2002), 2002 An exactly solvable model based on the topology of a protein native state is applied to identify bottlenecks and key-sites for the folding of HIV-1 Protease. The predicted sites are found to correlate well with clinical data on resistance to FDA-approved drugs.
Ala +48 more
arxiv +4 more sources
Current Protocols in Protein Science, 2000 AbstractThe processes of growth and remodeling of cells and tissues in multicellular organisms require the breakdown of old protein molecules, in concert with the synthesis of new ones. For example, many newly‐synthesized molecules require proteolytic processing to convert them to biologically active forms.
Jennifer L. Harris, Charles S. Craik
openaire +5 more sources
Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis
Frontiers in Medicine, 2023 ObjectivesOur objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics.BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-established ...
Camilla Margaroli +37 more
doaj +1 more source
Diet, microbiota, and the mucus layer: The guardians of our health
Frontiers in Immunology, 2022 The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of the host representing one of the main external factors ...
Francesco Suriano +3 more
doaj +1 more source
Protease inhibitors targeting the main protease and papain-like protease of coronaviruses [PDF]
Expert Opinion on Therapeutic Patents, 2020 The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals.We review the drug design landscape in the
Capasso, Clemente +2 more
openaire +4 more sources
Productive performance response of growing rabbits to dietary protein reduction and supplementation of pyridoxine, protease, and zinc [PDF]
Anais da Academia Brasileira de Ciências, 2020 An 8-week experiment was carried out to assess the impact of supplemental dietary pyridoxine (PY), protease (PR), zinc (Zn) and their mixture (MIX) with low protein diet (LP; 14.76% CP) or high protein diet (HP; 18.53% CP) on rabbit growth, feed ...
ADHAM A. AL-SAGHEER +4 more
doaj +1 more source
Frontiers in Microbiology, 2022 Condensed tannins (CT) from sainfoin have a high capacity to inhibit proteolysis. A previous study reported that CT from sainfoin can inhibit lactic acid bacteria activity and decrease ammonium-nitrogen (N) content during sainfoin ensiling; however, no ...
Rong Zheng Huang +3 more
doaj +1 more source