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Gastric Proteases and Protease Inhibitors
Gastroenterology, 1967 Harry L. Segal +2 more
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Cell Reports Medicine, 2021 Summary: Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear whether ARDS from SARS-CoV-2 is similar to that observed in
Camilla Margaroli +10 more
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Current Protocols in Protein Science, 2000 AbstractThe processes of growth and remodeling of cells and tissues in multicellular organisms require the breakdown of old protein molecules, in concert with the synthesis of new ones. For example, many newly‐synthesized molecules require proteolytic processing to convert them to biologically active forms.
Jennifer L. Harris, Charles S. Craik
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The endothelial glycocalyx in critical illness: A pediatric perspective
Matrix Biology Plus, 2022 The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through ...
Robert P. Richter +4 more
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Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis
Frontiers in Medicine, 2023 ObjectivesOur objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics.BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-established ...
Camilla Margaroli +37 more
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Diet, microbiota, and the mucus layer: The guardians of our health
Frontiers in Immunology, 2022 The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of the host representing one of the main external factors ...
Francesco Suriano +3 more
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Protease inhibitors targeting the main protease and papain-like protease of coronaviruses [PDF]
Expert Opinion on Therapeutic Patents, 2020 The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals.We review the drug design landscape in the
Capasso, Clemente +2 more
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Аграрная наука Евро-Северо-Востока, 2023 The paper presents data on a three-year study (2020-2022) of the effect of a liquid-phase biological product containing iron nanoparticles (LPB-Fe), obtained by biosynthesis using green tea extract, on the yield of potatoes of the Skarb variety and the ...
N. A. Lyubimova, G. Yu. Rabinovich
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Individual or combinational use of phytase, protease, and xylanase for the impacts on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble fed to pigs [PDF]
Animal Bioscience, 2023 Objective This study was to evaluate the effects of individual or combinational use of phytase, protease, and xylanase on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble (DDGS) fed to pigs.
Adsos Adami Passos +2 more
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