Results 1 to 10 of about 896,552 (245)

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures

Cell Reports Medicine, 2021
Summary: Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear whether ARDS from SARS-CoV-2 is similar to that observed in
Camilla Margaroli, Paul Benson, Nirmal S. Sharma, Matthew C. Madison, Sarah W. Robison, Nitin Arora, Kathy Ton, Yan Liang, Liang Zhang, Rakesh P. Patel, Amit Gaggar   +10 more
doaj   +1 more source

The endothelial glycocalyx in critical illness: A pediatric perspective

Matrix Biology Plus, 2022
The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through ...
Robert P. Richter, Gregory A. Payne, Namasivayam Ambalavanan, Amit Gaggar, Jillian R. Richter   +4 more
doaj   +1 more source

Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis

Frontiers in Medicine, 2023
ObjectivesOur objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics.BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-established ...
Camilla Margaroli, Camilla Margaroli, Paul Benson, Maria G. Gastanadui, Maria G. Gastanadui, Chunyan Song, Chunyan Song, Chunyan Song, Liliana Viera, Liliana Viera, Liliana Viera, Dongqi Xing, Dongqi Xing, Dongqi Xing, Dongqi Xing, Dongqi Xing, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, Rakesh Patel, Rakesh Patel, Rakesh Patel, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne   +37 more
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Diet, microbiota, and the mucus layer: The guardians of our health

Frontiers in Immunology, 2022
The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of the host representing one of the main external factors ...
Francesco Suriano, Elisabeth E. L. Nyström, Domenico Sergi, Jenny K. Gustafsson   +3 more
doaj   +1 more source

Proteases [PDF]

Current Protocols in Protein Science, 2000
AbstractThe processes of growth and remodeling of cells and tissues in multicellular organisms require the breakdown of old protein molecules, in concert with the synthesis of new ones. For example, many newly‐synthesized molecules require proteolytic processing to convert them to biologically active forms.
Harris, Jennifer L., Craik, Charles S.
openaire   +3 more sources

Individual or combinational use of phytase, protease, and xylanase for the impacts on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble fed to pigs [PDF]

Animal Bioscience, 2023
Objective This study was to evaluate the effects of individual or combinational use of phytase, protease, and xylanase on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble (DDGS) fed to pigs.
Adsos Adami Passos, Vitor Hugo Cardoso Moita, Sung Woo Kim   +2 more
doaj   +1 more source

Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model

Molecular Therapy: Oncolytics, 2023
Glioblastoma (GBM) is the most common aggressive malignant brain cancer and is chemo- and radioresistant, with poor therapeutic outcomes. The “double-edged sword” of virus-induced cell death could be a potential solution if the oncolytic virus ...
Yu-Ting Kao, Hsin-I Wang, Chi-Ting Shie, Chiou-Feng Lin, Michael M.C. Lai, Chia-Yi Yu   +5 more
doaj   +1 more source

Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential

Frontiers in Molecular Biosciences, 2021
Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt, Heike Brötz-Oesterhelt, Andreas Vorbach   +2 more
doaj   +1 more source

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke Alphey, Andres Merits   +4 more
doaj   +1 more source

Beyond Inhibition: A Novel Strategy of Targeting HIV-1 Protease to Eliminate Viral Reservoirs

Viruses, 2022
HIV-1 protease (PR) is a viral enzyme that cleaves the Gag and Gag-Pol polyprotein precursors to convert them into their functional forms, a process which is essential to generate infectious viral particles.
Josh G. Kim, Liang Shan
doaj   +1 more source